Stimulus-Responsive Nanodelivery and Release Systems for Cancer Gene Therapy: Efficacy Improvement Strategies
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7099 - 7121
Опубликована: Июль 1, 2024
Abstract:
Introduction
of
exogenous
genes
into
target
cells
to
overcome
various
tumor
diseases
caused
by
genetic
defects
or
abnormalities
and
gene
therapy,
a
new
treatment
method,
provides
promising
strategy
for
treatment.
Over
the
past
decade,
therapy
has
made
exciting
progress;
however,
it
still
faces
challenge
low
nucleic
acid
delivery
release
efficiencies.
The
emergence
nonviral
vectors,
primarily
nanodelivery
systems
(NDRS),
resulted
in
historic
breakthrough
application
therapy.
NDRS,
especially
stimulus-responsive
NDRS
that
can
respond
timely
manner
changes
internal
external
microenvironment
(eg,
pH,
high
concentration
glutathione/reactive
oxygen
species,
overexpressed
enzymes,
temperature,
light,
ultrasound,
magnetic
field),
shown
excellent
loading
advantages
precision
efficiency
been
widely
applied.
only
disadvantage
is
poor
transfection
limits
in-depth
clinical
practice,
owing
presence
biological
barriers
body.
Therefore,
this
review
first
introduces
development
history
current
obstacles
faced
delivery,
strategies
these
obstacles,
conventional
then
focuses
on
latest
research
progress
improving
efficiency.
Finally,
future
challenges
prospects
may
face
transformation
are
discussed
provide
references
enhancing
Keywords:
treatment,
efficiency,
microenvironment,
physiological
barrier,
efficacy
improvement
Язык: Английский
A new model for bubble cluster dynamics in a viscoelastic media
Xiaozhuo Shen,
Pengfei Wu,
Weijun Lin
и другие.
Ultrasonics Sonochemistry,
Год журнала:
2024,
Номер
107, С. 106890 - 106890
Опубликована: Апрель 27, 2024
Bubble
cluster
dynamics
in
viscoelastic
media
is
instructive
for
ultrasound
diagnosis
and
therapy.
In
this
paper,
we
propose
a
statistical
model
bubble
considering
the
radius
distribution
of
nuclei.
By
investigating
comparing
response
three
conditions:
single
bubble;
multi-bubble
with
same
radius;
different
radius,
following
rules
are
found:
The
promotion
or
suppression
on
vibration
not
monotonous
increase
number
bubbles.
varies
alternately
frequency.
effect
mostly
suppressed
when
driving
acoustic
pressure
amplitude
pa
high
(5000
kPa).
Usually,
promotes
large
bubbles
(R0
=
10
μm)
more,
suppresses
it
less.
Язык: Английский
Improving Microcystis aeruginosa removal efficiency through enhanced sonosensitivity of nitrogen-doped nanodiamonds
Ultrasonics Sonochemistry,
Год журнала:
2024,
Номер
109, С. 106993 - 106993
Опубликована: Июль 20, 2024
Traditional
methods
for
algae
removal
in
drinking
water
treatment,
such
as
coagulation
and
sedimentation,
face
challenges
due
to
the
negative
charge
on
cells'
surfaces,
resulting
ineffective
removal.
Ultrasonic
cavitation
has
shown
promise
enhancing
performance
by
disrupting
extracellular
polymer
structures
improving
cyanobacteria
through
various
mechanisms
like
shear
force
free
radical
reactions.
However,
short
lifespan
limited
mass
transfer
distance
of
radicals
conventional
ultrasonic
treatment
lead
high
energy
consumption,
limiting
widespread
application.
To
overcome
these
limitations
enhance
efficiency,
advanced
carbon-based
materials
were
developed
tested.
Nitrogen-doped
functional
groups
nanodiamond
surfaces
found
boost
sonosensitivity
increasing
production
reactive
oxygen
species
at
sonosensitizer-water
interface.
Utilizing
low-power
ultrasound
(0.12
W/mL)
combination
with
N-ND
5
min,
rates
Microcystis
aeruginosa
cells
exceeded
90
%,
enhanced
algal
organic
matters
microcystins
water.
Visualization
confocal
microscopy
highlighted
role
positively
charged
nitrogen-doped
nanodiamonds
aggregating
cells.
The
synergy
between
cell
capturing
catalysis
indicates
that
efficient
from
sonosensitizer's
surface
microalgae's
is
critical
promoting
floc
formation.
This
study
underscores
potential
employing
a
low-intensity
system
effectively
processes.
Язык: Английский
Shock wave and microjet produced by bubble collapse in cavitation ultrasonic surface rolling
Proceedings of the Institution of Mechanical Engineers Part C Journal of Mechanical Engineering Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
The
introduction
of
the
cavitation
effect
in
ultrasonic
surface
rolling
can
further
improve
strengthening
effect.
However,
mechanism
time-space
bubble
collapse
on
material
wall
is
still
uncertain.
Therefore,
this
study,
both
shock
wave
produced
by
spherical
and
microjet
generated
non-spherical
were
investigated.
A
dynamic
model
area
was
established,
pressure
analyzed
numerically.
numerical
results
reveal
that
significantly
influenced
amplitude.
As
amplitude
increased
from
2
to
5
μm,
maximum
rose
4700
38690
MPa,
while
75.07
416.07
MPa.
Additionally,
distribution
caused
near-wall
determined
using
computational
fluid
dynamics
(CFD)
analysis
method.
microjets
peaked
with
a
slight
delay
compared
waves,
reaching
value
20.25
MPa
when
normalized
standoff
distance
0.6.
Finally,
erosion
experiments
conducted.
showed
approximately
between
340
382
which
generally
consistent
previous
calculation
results.
This
indicates
plays
dominant
role
rolling.
These
research
findings
are
crucial
for
studies
formation
residual
stresses
microstructure
evolution
Язык: Английский
Residual Stress and Microstructure Evolution of 7075 Aluminum Induced by Ultrasonic Surface Rolling Coupled with Cavitation
Journal of Materials Engineering and Performance,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Язык: Английский
Improved assessment sensitivity of time-varying cavitation events based on wavelet analysis
Ultrasonics,
Год журнала:
2023,
Номер
138, С. 107227 - 107227
Опубликована: Дек. 15, 2023
Язык: Английский
Advanced cavitation agents: A comprehensive review of micro/nano-sonocatalysts and sonosensitizers
BME Frontiers,
Год журнала:
2024,
Номер
5
Опубликована: Янв. 1, 2024
Sonodynamic
therapy
(SDT)
has
emerged
as
a
novel
and
highly
researched
advancement
in
the
medical
field.
Traditional
ultrasound
contrast
agents
bubble-shaped
are
used
to
stimulate
cavitation
enhance
SDT
efficiency.
However,
impact
of
artificially
modified
shell
structures
on
acoustic
properties
microbubbles
remains
be
explored.
Alternatively,
absence
agents,
some
clinically
available
organic
sonosensitizers
advanced
inorganic
materials
also
efficacy
SDT.
Diagnostic
therapeutic
can
activate
bubbles,
which
supply
energy
sonosensitive
leading
production
cytotoxic
free
radicals
achieve
effects.
While
often
spark
controversy
clinical
applications,
their
relatively
simple
structure
enables
researchers
gain
insight
into
mechanism
by
produces
various
radicals.
Some
organic–inorganic
hybrid
systems
have
been
reported,
combining
benefits
agents.
employing
cell
surface
modification
engineering
enable
cells
perform
functions
such
immune
escape,
drug
loading,
gas
sonosensitivity,
cellular
developed.
further
exploration
is
needed
properties,
ability
generate
reactive
oxygen
species
(ROS),
potential
application
this
sonosensitizer.
This
review
offers
comprehensive
analysis
vesical
nanoscale
sonocatalysts,
including
organic,
inorganic,
combined
sonosensitizers,
sonosensitizers.
will
our
understanding
demonstrate
its
important
transforming
applications.
Язык: Английский
Shock Wave and Microjet Produced by Bubble Collapse in Cavitation Ultrasonic Surface Rolling
Опубликована: Янв. 1, 2024
The
introduction
of
cavitation
effect
in
ultrasonic
surface
rolling
can
further
improve
the
strengthening
effect,
but
mechanism
time-space
bubble
collapse
on
material
wall
is
still
uncertain.
Therefore,
this
work,
shock
wave
produced
by
spherical
and
microjet
non-spherical
were
investigated.
dynamics
model
area
was
established,
pressure
obtained
through
numerical
analysis.
Additionally,
distribution
near-wall
determined
using
computational
fluid
analysis
method.
Finally,
erosion
experiments
conducted.
results
show
that
generated
a
plays
dominant
role
rolling,
while
negligible.
These
research
findings
are
important
for
studies
formation
residual
stresses
microstructure
evolution
rolling.
Язык: Английский
Improving Microcystis Aeruginosa Removal Efficiency Through Enhanced Sonosensitivity of Nitrogen-Doped Nanodiamonds
Опубликована: Янв. 1, 2024
Traditional
methods
for
algae
removal
in
drinking
water
treatment,
such
as
coagulation
and
sedimentation,
face
challenges
due
to
the
negative
charge
on
cells'
surfaces,
resulting
ineffective
removal.
Ultrasonic
cavitation
has
shown
promise
enhancing
performance
by
disrupting
extracellular
polymer
structures
improving
cyanobacteria
through
various
mechanisms
like
shear
force
free
radical
reactions.
However,
short
lifespan
limited
mass
transfer
distance
of
radicals
conventional
ultrasonic
treatment
lead
high
energy
consumption,
limiting
widespread
application.
To
overcome
these
limitations
enhance
efficiency,
advanced
carbon-based
materials
were
developed
tested.
Nitrogen-doped
functional
groups
nanodiamond
surfaces
found
boost
sonosensitivity
increasing
production
reactive
oxygen
species
at
sonosensitizer-water
interface.
Utilizing
low-power
ultrasound
(0.12
W/mL)
combination
with
N-ND
5
minutes,
rates
Microcystis
aeruginosa
cells
exceeded
90%,
enhanced
algal
organic
matters
microcystins
water.
Visualization
confocal
microscopy
highlighted
role
positively
charged
nitrogen-doped
nanodiamonds
aggregating
cells.
The
synergy
between
cell
capturing
catalysis
indicates
that
efficient
from
sonosensitizer's
surface
microalgae's
is
critical
promoting
floc
formation.
This
study
underscores
potential
employing
a
low-intensity
system
effectively
processes.
Язык: Английский
2D spatiotemporal passive cavitation imaging and evaluation during ultrasound thrombolysis based on diagnostic ultrasound platform
Ultrasonics Sonochemistry,
Год журнала:
2024,
Номер
110, С. 107051 - 107051
Опубликована: Авг. 31, 2024
Acoustic
cavitation
plays
a
critical
role
in
various
biomedical
applications.
However,
uncontrolled
can
lead
to
undesired
damage
healthy
tissues.
Therefore,
real-time
monitoring
and
quantitative
evaluation
of
dynamics
is
essential
for
understanding
underlying
mechanisms
optimizing
ultrasound
treatment
efficiency
safety.
The
current
research
addressed
the
limitations
traditionally
used
detection
methods
by
developing
introduced
an
adaptive
time-division
multiplexing
passive
imaging
(PCI)
system
integrated
into
commercial
diagnostic
platform.
This
new
method
combined
with
B-mode
imaging,
allowing
simultaneous
visualization
progress
2D
dosage
within
targeted
area.
An
improved
delay-and-sum
(DAS)
algorithm,
optimized
minimum
variance
(MV)
beamformer,
utilized
minimize
side
lobe
effect
improve
axial
resolution
typically
associated
PCI.
In
additional
visualize
quantitatively
assess
activities
generated
under
varied
acoustic
pressures
microbubble
concentrations,
this
was
specifically
applied
perform
thrombolysis
mediated
different
solutions,
e.g.,
saline,
nanodiamond
(ND)
nitrogen-annealed
(N-AND).
aims
bridge
gap
between
laboratory-based
systems
spatiotemporal
demands
practical
uses.
Results
indicate
that
could
offer
useful
tool
comprehensive
evaluating
cavitation-mediated
effects
(e.g.,
thrombolysis),
providing
valuable
insights
in-depth
optimization
Язык: Английский