2D spatiotemporal passive cavitation imaging and evaluation during ultrasound thrombolysis based on diagnostic ultrasound platform DOI Creative Commons
Qi Zhang, Yifei Zhu, Guofeng Zhang

et al.

Ultrasonics Sonochemistry, Journal Year: 2024, Volume and Issue: 110, P. 107051 - 107051

Published: Aug. 31, 2024

Acoustic cavitation plays a critical role in various biomedical applications. However, uncontrolled can lead to undesired damage healthy tissues. Therefore, real-time monitoring and quantitative evaluation of dynamics is essential for understanding underlying mechanisms optimizing ultrasound treatment efficiency safety. The current research addressed the limitations traditionally used detection methods by developing introduced an adaptive time-division multiplexing passive imaging (PCI) system integrated into commercial diagnostic platform. This new method combined with B-mode imaging, allowing simultaneous visualization progress 2D dosage within targeted area. An improved delay-and-sum (DAS) algorithm, optimized minimum variance (MV) beamformer, utilized minimize side lobe effect improve axial resolution typically associated PCI. In additional visualize quantitatively assess activities generated under varied acoustic pressures microbubble concentrations, this was specifically applied perform thrombolysis mediated different solutions, e.g., saline, nanodiamond (ND) nitrogen-annealed (N-AND). aims bridge gap between laboratory-based systems spatiotemporal demands practical uses. Results indicate that could offer useful tool comprehensive evaluating cavitation-mediated effects (e.g., thrombolysis), providing valuable insights in-depth optimization

Language: Английский

Stimulus-Responsive Nanodelivery and Release Systems for Cancer Gene Therapy: Efficacy Improvement Strategies DOI Creative Commons
Huamin Zeng, Yiran Zhang, Ningyi Liu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7099 - 7121

Published: July 1, 2024

Abstract: Introduction of exogenous genes into target cells to overcome various tumor diseases caused by genetic defects or abnormalities and gene therapy, a new treatment method, provides promising strategy for treatment. Over the past decade, therapy has made exciting progress; however, it still faces challenge low nucleic acid delivery release efficiencies. The emergence nonviral vectors, primarily nanodelivery systems (NDRS), resulted in historic breakthrough application therapy. NDRS, especially stimulus-responsive NDRS that can respond timely manner changes internal external microenvironment (eg, pH, high concentration glutathione/reactive oxygen species, overexpressed enzymes, temperature, light, ultrasound, magnetic field), shown excellent loading advantages precision efficiency been widely applied. only disadvantage is poor transfection limits in-depth clinical practice, owing presence biological barriers body. Therefore, this review first introduces development history current obstacles faced delivery, strategies these obstacles, conventional then focuses on latest research progress improving efficiency. Finally, future challenges prospects may face transformation are discussed provide references enhancing Keywords: treatment, efficiency, microenvironment, physiological barrier, efficacy improvement

Language: Английский

Citations

6
A new model for bubble cluster dynamics in a viscoelastic media DOI Creative Commons

Xiaozhuo Shen,

Pengfei Wu,

Weijun Lin

et al.

Ultrasonics Sonochemistry, Journal Year: 2024, Volume and Issue: 107, P. 106890 - 106890

Published: April 27, 2024

Bubble cluster dynamics in viscoelastic media is instructive for ultrasound diagnosis and therapy. In this paper, we propose a statistical model bubble considering the radius distribution of nuclei. By investigating comparing response three conditions: single bubble; multi-bubble with same radius; different radius, following rules are found: The promotion or suppression on vibration not monotonous increase number bubbles. varies alternately frequency. effect mostly suppressed when driving acoustic pressure amplitude pa high (5000 kPa). Usually, promotes large bubbles (R0 = 10 μm) more, suppresses it less.

Language: Английский

Citations

4
Improving Microcystis aeruginosa removal efficiency through enhanced sonosensitivity of nitrogen-doped nanodiamonds DOI Creative Commons
Xiaoge Wu,

Yang Su,

Wenshu Li

et al.

Ultrasonics Sonochemistry, Journal Year: 2024, Volume and Issue: 109, P. 106993 - 106993

Published: July 20, 2024

Traditional methods for algae removal in drinking water treatment, such as coagulation and sedimentation, face challenges due to the negative charge on cells' surfaces, resulting ineffective removal. Ultrasonic cavitation has shown promise enhancing performance by disrupting extracellular polymer structures improving cyanobacteria through various mechanisms like shear force free radical reactions. However, short lifespan limited mass transfer distance of radicals conventional ultrasonic treatment lead high energy consumption, limiting widespread application. To overcome these limitations enhance efficiency, advanced carbon-based materials were developed tested. Nitrogen-doped functional groups nanodiamond surfaces found boost sonosensitivity increasing production reactive oxygen species at sonosensitizer-water interface. Utilizing low-power ultrasound (0.12 W/mL) combination with N-ND 5 min, rates Microcystis aeruginosa cells exceeded 90 %, enhanced algal organic matters microcystins water. Visualization confocal microscopy highlighted role positively charged nitrogen-doped nanodiamonds aggregating cells. The synergy between cell capturing catalysis indicates that efficient from sonosensitizer's surface microalgae's is critical promoting floc formation. This study underscores potential employing a low-intensity system effectively processes.

Language: Английский

Citations

3
Shock wave and microjet produced by bubble collapse in cavitation ultrasonic surface rolling DOI
Junhua Li, Jianxin Zheng,

Yingju Shang

et al.

Proceedings of the Institution of Mechanical Engineers Part C Journal of Mechanical Engineering Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

The introduction of the cavitation effect in ultrasonic surface rolling can further improve strengthening effect. However, mechanism time-space bubble collapse on material wall is still uncertain. Therefore, this study, both shock wave produced by spherical and microjet generated non-spherical were investigated. A dynamic model area was established, pressure analyzed numerically. numerical results reveal that significantly influenced amplitude. As amplitude increased from 2 to 5 μm, maximum rose 4700 38690 MPa, while 75.07 416.07 MPa. Additionally, distribution caused near-wall determined using computational fluid dynamics (CFD) analysis method. microjets peaked with a slight delay compared waves, reaching value 20.25 MPa when normalized standoff distance 0.6. Finally, erosion experiments conducted. showed approximately between 340 382 which generally consistent previous calculation results. This indicates plays dominant role rolling. These research findings are crucial for studies formation residual stresses microstructure evolution

Language: Английский

Citations

0
Residual Stress and Microstructure Evolution of 7075 Aluminum Induced by Ultrasonic Surface Rolling Coupled with Cavitation DOI
Junhua Li, Jianxin Zheng,

Liuyin Jia

et al.

Journal of Materials Engineering and Performance, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
Improved assessment sensitivity of time-varying cavitation events based on wavelet analysis DOI
Qi Zhang, Guofeng Zhang,

Lan Luo

et al.

Ultrasonics, Journal Year: 2023, Volume and Issue: 138, P. 107227 - 107227

Published: Dec. 15, 2023

Language: Английский

Citations

4
Advanced cavitation agents: A comprehensive review of micro/nano-sonocatalysts and sonosensitizers DOI Creative Commons
Xiaoge Wu, Fulong Chen, Qi Zhang

et al.

BME Frontiers, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

Sonodynamic therapy (SDT) has emerged as a novel and highly researched advancement in the medical field. Traditional ultrasound contrast agents bubble-shaped are used to stimulate cavitation enhance SDT efficiency. However, impact of artificially modified shell structures on acoustic properties microbubbles remains be explored. Alternatively, absence agents, some clinically available organic sonosensitizers advanced inorganic materials also efficacy SDT. Diagnostic therapeutic can activate bubbles, which supply energy sonosensitive leading production cytotoxic free radicals achieve effects. While often spark controversy clinical applications, their relatively simple structure enables researchers gain insight into mechanism by produces various radicals. Some organic–inorganic hybrid systems have been reported, combining benefits agents. employing cell surface modification engineering enable cells perform functions such immune escape, drug loading, gas sonosensitivity, cellular developed. further exploration is needed properties, ability generate reactive oxygen species (ROS), potential application this sonosensitizer. This review offers comprehensive analysis vesical nanoscale sonocatalysts, including organic, inorganic, combined sonosensitizers, sonosensitizers. will our understanding demonstrate its important transforming applications.

Language: Английский

Citations

1
Shock Wave and Microjet Produced by Bubble Collapse in Cavitation Ultrasonic Surface Rolling DOI
Jianxin Zheng, Junhua Li,

Yingju Shang

et al.

Published: Jan. 1, 2024

The introduction of cavitation effect in ultrasonic surface rolling can further improve the strengthening effect, but mechanism time-space bubble collapse on material wall is still uncertain. Therefore, this work, shock wave produced by spherical and microjet non-spherical were investigated. dynamics model area was established, pressure obtained through numerical analysis. Additionally, distribution near-wall determined using computational fluid analysis method. Finally, erosion experiments conducted. results show that generated a plays dominant role rolling, while negligible. These research findings are important for studies formation residual stresses microstructure evolution rolling.

Language: Английский

Citations

0
Improving Microcystis Aeruginosa Removal Efficiency Through Enhanced Sonosensitivity of Nitrogen-Doped Nanodiamonds DOI
Xiaoge Wu,

Yang Su,

Wenshu Li

et al.

Published: Jan. 1, 2024

Traditional methods for algae removal in drinking water treatment, such as coagulation and sedimentation, face challenges due to the negative charge on cells' surfaces, resulting ineffective removal. Ultrasonic cavitation has shown promise enhancing performance by disrupting extracellular polymer structures improving cyanobacteria through various mechanisms like shear force free radical reactions. However, short lifespan limited mass transfer distance of radicals conventional ultrasonic treatment lead high energy consumption, limiting widespread application. To overcome these limitations enhance efficiency, advanced carbon-based materials were developed tested. Nitrogen-doped functional groups nanodiamond surfaces found boost sonosensitivity increasing production reactive oxygen species at sonosensitizer-water interface. Utilizing low-power ultrasound (0.12 W/mL) combination with N-ND 5 minutes, rates Microcystis aeruginosa cells exceeded 90%, enhanced algal organic matters microcystins water. Visualization confocal microscopy highlighted role positively charged nitrogen-doped nanodiamonds aggregating cells. The synergy between cell capturing catalysis indicates that efficient from sonosensitizer's surface microalgae's is critical promoting floc formation. This study underscores potential employing a low-intensity system effectively processes.

Language: Английский

Citations

0
2D spatiotemporal passive cavitation imaging and evaluation during ultrasound thrombolysis based on diagnostic ultrasound platform DOI Creative Commons
Qi Zhang, Yifei Zhu, Guofeng Zhang

et al.

Ultrasonics Sonochemistry, Journal Year: 2024, Volume and Issue: 110, P. 107051 - 107051

Published: Aug. 31, 2024

Acoustic cavitation plays a critical role in various biomedical applications. However, uncontrolled can lead to undesired damage healthy tissues. Therefore, real-time monitoring and quantitative evaluation of dynamics is essential for understanding underlying mechanisms optimizing ultrasound treatment efficiency safety. The current research addressed the limitations traditionally used detection methods by developing introduced an adaptive time-division multiplexing passive imaging (PCI) system integrated into commercial diagnostic platform. This new method combined with B-mode imaging, allowing simultaneous visualization progress 2D dosage within targeted area. An improved delay-and-sum (DAS) algorithm, optimized minimum variance (MV) beamformer, utilized minimize side lobe effect improve axial resolution typically associated PCI. In additional visualize quantitatively assess activities generated under varied acoustic pressures microbubble concentrations, this was specifically applied perform thrombolysis mediated different solutions, e.g., saline, nanodiamond (ND) nitrogen-annealed (N-AND). aims bridge gap between laboratory-based systems spatiotemporal demands practical uses. Results indicate that could offer useful tool comprehensive evaluating cavitation-mediated effects (e.g., thrombolysis), providing valuable insights in-depth optimization

Language: Английский

Citations

0