Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(39)
Опубликована: Сен. 16, 2024
Long
COVID
occurs
in
a
small
but
important
minority
of
patients
following
COVID-19,
reducing
quality
life
and
contributing
to
healthcare
burden.
Although
research
into
underlying
mechanisms
is
evolving,
immunity
understudied.
SARS-CoV-2-specific
T
cell
responses
are
key
importance
for
viral
clearance
COVID-19
recovery.
However,
long
COVID,
the
establishment
persistence
cells
far
from
clear,
especially
beyond
12
mo
postinfection
postvaccination.
We
defined
ex
vivo
antigen-specific
B
their
receptors
(TCR)
repertoires
across
2
y
people
with
COVID.
Using
13
SARS-CoV-2
peptide–HLA
tetramers,
spanning
11
HLA
allotypes,
as
well
spike
nucleocapsid
probes,
we
tracked
CD8
+
CD4
B-cells
individuals
first
infection
through
primary
vaccination
over
24
mo.
The
frequencies
ORF1a-
nucleocapsid-specific
remained
stable
Spike-specific
were
boosted
by
vaccination,
indicating
immunization,
fully
recovered
altered
immunodominance
hierarchy
epitopes.
Meanwhile,
influenza-specific
mo,
suggesting
no
bystander-activation.
Compared
total
populations,
enriched
central
memory
phenotype,
although
proportion
decreased
acute
illness.
Importantly,
TCR
repertoire
composition
was
maintained
throughout
including
postvaccination,
postinfection.
Overall,
understand
recall
responses,
providing
insights
Journal of Applied Physiology,
Год журнала:
2023,
Номер
135(4), С. 902 - 917
Опубликована: Сен. 7, 2023
Following
acute
coronavirus
disease
2019
(COVID-19),
a
substantial
proportion
of
patients
showed
symptoms
and
sequelae
for
several
months,
namely
the
postacute
COVID-19
(PASC)
syndrome.
Major
phenomena
are
exercise
intolerance,
muscle
weakness,
fatigue.
We
aimed
to
investigate
physiopathology
intolerance
in
with
PASC
syndrome
by
structural
functional
analyses
skeletal
muscle.
At
least
3
mo
after
infection,
nonhospitalized
(
Vaccines,
Год журнала:
2024,
Номер
12(2), С. 189 - 189
Опубликована: Фев. 12, 2024
This
systematic
review
critically
evaluated
the
impact
of
a
pre-infection
COVID-19
vaccination
on
incidence
and
severity
post-COVID-19
syndrome
aimed
to
assess
potential
protective
effect
across
different
vaccines
patient
demographics.
study
hypothesized
that
before
infection
substantially
reduces
risk
syndrome.
In
October
2023,
comprehensive
literature
search
was
conducted
three
databases,
PubMed,
Embase,
Scopus,
focusing
studies
published
up
date.
Utilizing
wide
array
keywords,
strategy
adhered
PRISMA
guidelines
registered
in
Open
Science
Framework.
The
inclusion
criteria
comprised
patients
with
breakthrough
SARS-CoV-2
who
developed
We
included
total
13
articles
met
criteria,
analyzing
more
than
10
million
mean
age
50.6
years,
showing
intensive
care
unit
(ICU)
admissions
post-vaccination
as
low
2.4%,
significant
reduction
mortality
(OR
0.66,
95%
CI
0.58–0.74).
prevalence
symptoms
lower
vaccinated
individuals
(9.5%)
compared
unvaccinated
(14.6%),
notable
decrease
activity-limiting
(adjusted
OR
0.59,
0.48–0.73).
Vaccinated
also
showed
quicker
recovery
return
work
(HR
1.37,
1.04–1.79).
pooled
odds
ratio
0.77
indicates
is
associated
23%
developing
(95%
0.75–0.79).
Despite
effects
observed,
substantial
heterogeneity
among
noted.
conclusion,
However,
observed
suggests
need
for
further
research
standardized
methods
fully
comprehend
vaccine
efficacy
against
long
COVID.
Psychiatry and Clinical Neurosciences,
Год журнала:
2022,
Номер
77(2), С. 72 - 83
Опубликована: Сен. 23, 2022
The
novel
coronavirus
disease
19
(COVID‐19),
caused
by
severe
acute
respiratory
syndrome
2
(SARS‐CoV‐2),
can
have
two
phases:
(generally
4
weeks
after
onset)
and
chronic
(>4
onset).
Both
phases
include
a
wide
variety
of
signs
symptoms
including
neurological
psychiatric
symptoms.
that
are
considered
sequelae
COVID‐19
termed
post‐COVID
condition,
long
COVID‐19,
post‐acute
SARS‐CoV‐2
infection
(PASC).
PASC
fatigue,
dyspnea,
palpitation,
dysosmia,
subfever,
hypertension,
alopecia,
sleep
problems,
loss
concentration,
amnesia,
numbness,
pain,
gastrointestinal
symptoms,
depression,
anxiety.
Because
the
specific
pathophysiology
has
not
yet
been
clarified,
there
no
definite
criteria
hence
World
Health
Organization's
definition
is
quite
broad.
Consequently,
it
difficult
to
correctly
diagnose
PASC.
Approximately
50%
patients
may
show
at
least
one
symptom
up
12
months
infection;
however,
exact
prevalence
determined.
Despite
extensive
research
in
progress
worldwide,
currently
clear
diagnostic
methodologies
or
treatments
for
In
this
review,
we
discuss
available
information
on
highlight
infection.
Furthermore,
provide
clinical
suggestions
diagnosing
caring
with
based
our
outpatient
clinic
experience.
Journal of Global Health,
Год журнала:
2022,
Номер
12
Опубликована: Окт. 26, 2022
The
sustained
transmission
of
SARS-CoV-2,
future
variants
concern
and
the
confirmed
projection
increasing
Long
COVID
prevalence,
pose
a
significant
risk
to
public
health.
Journal of Neurochemistry,
Год журнала:
2022,
Номер
165(2), С. 115 - 130
Опубликована: Дек. 2, 2022
Abstract
As
the
world
continues
to
experience
effects
of
SARS‐CoV‐2,
there
is
evidence
suggest
that
sequelae
viral
infection
(the
post‐COVID‐19
condition;
PCC)
at
both
an
individual
and
population
level
will
be
significant
long‐lasting.
The
history
pandemics
or
epidemics
in
last
100
years
caused
by
members
RNA
virus
family,
which
coronaviruses
are
a
member,
provides
ample
acute
neurological
effects.
However,
except
for
H1N1
influenza
pandemic
1918/1919
Spanish
flu)
with
its
associated
encephalitis
lethargica,
little
information
on
long‐term
sequelae.
COVID‐19
first
has
occurred
setting
aging
population,
especially
several
high‐income
countries.
Its
survivors
greatest
risk
developing
neurodegenerative
conditions
as
they
age,
rendering
current
unique
paradigm
not
previously
witnessed.
SARS‐CoV‐2
virus,
among
largest
viruses,
single‐stranded
encodes
29
proteins
include
spike
protein
contains
key
domains
required
ACE2
binding,
complex
array
nonstructural
(NSPs)
accessory
ensure
escape
from
innate
immune
response,
allowing
efficient
replication,
translation,
exocytosis
fully
functional
virion.
Increasingly,
these
also
recognized
potentially
contributing
biochemical
molecular
processes
underlying
neurodegeneration.
In
addition
directly
being
taken
up
brain
endothelium,
constituents
can
transported
neurons,
astrocytes,
microglia
extracellular
vesicles
accelerate
pathological
fibril
formation.
nucleocapsid
intrinsically
disordered
participate
liquid
condensate
formation,
including
heteropolymers
disease‐associated
RNA‐binding
such
TDP‐43,
FUS,
hnRNP1A.
mutate
under
pressure
exerted
highly
efficacious
vaccines,
it
evolving
into
greater
transmissibility
but
less
severity
compared
original
strain.
potential
lingering
impact
nervous
system
thus
represent
ongoing
legacy
even
global
health
challenge
than
infection.
image
Science Translational Medicine,
Год журнала:
2023,
Номер
15(712)
Опубликована: Сен. 6, 2023
Beyond
the
acute
illness
caused
by
severe
respiratory
coronavirus
2
(SARS-CoV-2)
infection,
about
one-fifth
of
infections
result
in
long-term
persistence
symptoms
despite
apparent
clearance
infection.
Insights
into
mechanisms
that
underlie
postacute
sequelae
COVID-19
(PASC)
will
be
critical
for
prevention
and
clinical
management
complications
COVID-19.
Several
hypotheses
have
been
proposed
may
account
development
PASC,
including
virus
dysregulation
immune
responses.
Among
immunological
changes
noted
alterations
humoral
immunity
observed
some
patient
subsets.
To
begin
to
determine
whether
SARS-CoV-2–
or
other
pathogen-specific
responses
evolve
uniquely
we
performed
comprehensive
antibody
profiling
against
SARS-CoV-2,
a
panel
endemic
pathogens,
routine
vaccine
antigens
using
systems
serology
two
cohorts
patients
with
preexisting
systemic
autoimmune
rheumatic
disease
(SARD)
who
either
developed
did
not
develop
PASC.
A
distinct
qualitative
shift
Fcγ
receptor
(FcγR)
binding
was
individuals
Specifically,
PASC
harbored
weaker
FcγR-binding
anti–SARS-CoV-2
antibodies
stronger
OC43.
Individuals
an
OC43
S2-specific
response
FcγR
binding,
linked
cross-reactivity
across
SARS-CoV-2
common
coronaviruses.
These
findings
identify
previous
imprinting
as
potential
marker
SARDs.
