Опубликована: Янв. 1, 2024
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Язык: Английский
Viruses, Год журнала: 2024, Номер 16(5), С. 680 - 680
Опубликована: Апрель 26, 2024
The human papillomavirus is the most common sexually transmitted infection in world. Most HPV infections clear spontaneously within 2 years of infection; however, persistent can result a wide array diseases, ranging from genital warts to cancer. cases cervical, anal, and oropharyngeal cancers are due infection, with cervical cancer being one leading causes death women worldwide. Screening available for cancer, but not everywhere, particularly lower-resource settings. disproportionally affects individuals living HIV, resulting decreased clearance, increased development mortality. vaccine has shown drastic decrease HPV-related diseases. prevents near 100% efficacy, if given prior first sexual activity. Vaccination uptake remains low worldwide lack access limited knowledge HPV. Increasing awareness vaccination necessary morbidity mortality
Язык: Английский
Процитировано
29
The Lancet Respiratory Medicine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Virology Journal, Год журнала: 2024, Номер 21(1)
Опубликована: Май 31, 2024
Abstract Cervical cancer (CC) and other malignant malignancies are acknowledged to be primarily caused by persistent human papillomavirus (HPV) infection. Historically, vaccinations against viruses that produce neutralizing antibodies unique the virus have been an affordable way manage viral diseases. CC risk is decreased, but not eliminated, HPV vaccinations. Since made available globally, almost 90% of infections successfully avoided. On lesions diseases already present, however, no discernible treatment benefit has shown. As a result, therapeutic vaccines elicit immune responses mediated cells necessary for established cancers. mRNA possess remarkable potential in combating malignancy as result their superior industrial production, safety, efficacy. Furthermore, considering expeditiousness vaccine exhibits promise approach targeting HPV. Given HPV-encoded early proteins, including oncoproteins E6 E7, consistently present HPV-related cancers pre-cancerous crucial functions progression persistence diseases, they serve ideal targets vaccines. The action mechanism vaccines, recent advancements clinical trials, applications highlighted this study, which also offers quick summary state Lastly, we highlight few difficulties with vaccination practice provide our thoughts on further quickly changing sector. It expected will soon produced prevention treatment. Graphical
Язык: Английский
Процитировано
12
Chemical Engineering Journal, Год журнала: 2024, Номер 486, С. 150356 - 150356
Опубликована: Март 14, 2024
Язык: Английский
Процитировано
9
Behavioral Medicine, Год журнала: 2025, Номер unknown, С. 1 - 22
Опубликована: Янв. 24, 2025
Human papillomavirus (HPV) vaccination among males is poorly understood. We systematically reviewed individual socioeconomic/health-related characteristics associated with HPV vaccine initiation and series completion in the United States. searched for literature up to August 1, 2023, pooled appropriate multivariable-adjusted results using an inverse variance random effects model, expressed as odds ratios. Among pediatric (<18 years old), we observed moderately increased of urban residence, being a Black/Hispanic male versus White male, public private health insurance, visiting care provider past year. Influenza year strongly odds. Further, residence having parent lower/no education completion, whereas influenza adult (≥18 US-born, unemployed, unmarried/separated/divorced/widowed; states Northern Western region; had sexually transmitted infection; gay/bisexual. Younger age, living Southern region, visited higher education, unmarried/separated/divorced/widowed, Black primary physician insurance gay/bisexual These findings may inform age-targeted future program planning.
Язык: Английский
Процитировано
1
Immunology and Cell Biology, Год журнала: 2025, Номер unknown
Опубликована: Март 2, 2025
Abstract Effective scientific communication fosters public support and trust in research, establishing a stronger understanding of health disease. Making STEM education more accessible is crucial for blind, low‐vision diverse‐needs (BLVDN) communities, where grasping complex biomedical concepts can be challenging. Such accessibility promotes equal opportunities encourages innovation through diverse perspectives. This paper examines the Sensory Science Cambridge exhibition, held at Festival March 2024, aiming to enhance BLVDN inspired by Monash Australia. The exhibition included several tactile exhibits, including one designed educate on nature human papillomavirus (HPV) infections their link cervical cancer diorama art piece. We were guided question: How sensory materials convey HPV infection its progression cancer? To achieve this, we developed independent navigation, featuring braille keys, explanatory panels verbal descriptions. was created collaboration between scientists artists, effectiveness evaluated participant feedback observational studies during exhibition. significantly improved participants’ cancer, providing new or building existing knowledge. success this project provides model using education. It highlights potential science approaches making underscores importance interdisciplinary creating accessible, scientifically rigorous tools, offering insights future inclusive outreach.
Язык: Английский
Процитировано
1
Journal of Cellular Immunology, Год журнала: 2023, Номер 5(4), С. 127 - 140
Опубликована: Ноя. 29, 2023
Background: Cancer remains a leading cause of mortality with modest declines, highlighting the need for more efficacious prevention strategies like early immunological intervention against premalignant disease. Main body abstract: Oncogenic viruses demonstrate prophylactic vaccines can successfully reduce malignancy by blocking precipitating infections. However, most cancers lack viral etiology, requiring novel approaches targeting sporadic precancerous states to enable immunoprevention. Preneoplastic tissues exhibit biological changes making them appealing targets stimulating immune surveillance before additional mutations unconstrained proliferation. High-risk precancers also provide sources dysregulated self-antigens. Yet challenges exist in lesion identification, overcoming tolerance, and avoiding inflammation potentially worsening progression. Multidisciplinary insights into precancer immunology, predictive biomarkers, antigen discovery, combinatorial vaccination are illuminating rational vaccine design. Despite obstacles, immunization dysplastic holds disruptive potential if key steps advance this approach. Elucidating preneoplasia immunobiology progression risk modeling will be critical guide productive while mitigating immunotherapy hazards. Thoughtful translation could eventually shift paradigms priming immunosurveillance peak vulnerability lesions. Short Conclusion: Advancements may profoundly expand horizons. Cautious intercept toward widely disseminated malignancies. This warrants methodical efforts unravel promise thwarting lethal they start.
Язык: Английский
Процитировано
18
Cytokine & Growth Factor Reviews, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
6
Hematology/Oncology Clinics of North America, Год журнала: 2024, Номер 38(4), С. 771 - 781
Опубликована: Май 16, 2024
Язык: Английский
Процитировано
5
Molecular Therapy, Год журнала: 2024, Номер 32(7), С. 2340 - 2356
Опубликована: Май 6, 2024
Язык: Английский
Процитировано
4