Feast for thought: A comprehensive review of food allergy 2021-2023

Journal of Allergy and Clinical Immunology, Год журнала: 2023, Номер 153(3), С. 576 - 594

Опубликована: Дек. 12, 2023

This review covers the latest publications in food allergy over last couple of years.Food is a major public health concern, affecting about 8% children and 10% adults developed countries.The prevalence varies around world, with environmental factors mainly driving increase, possibly together genetical susceptibility to changes.A precise diagnosis extremely important -both new tests (e.g.basophil activation test) improved optimization information provided by existing (e.g.skin prick test specific IgE) can contribute improving accuracy patients' comfort diagnosis.Understanding underlying immune mechanisms fundamental designing allergen-specific treatments that be safe effective long-term.New discoveries have emerged at various levels response allergens, including T cell B responses.Novel therapeutic approaches are being trialed stages development will hopefully allow for more active intervention treat allergy.Prevention key reduce increase prevalence.Early introduction allergenic foods seems most intervention, but others studied, lead modification epidemiological trajectory time.

Язык: Английский

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The clinical burden of food allergies: Insights from the Food Allergy Research & Education (FARE) Patient Registry

World Allergy Organization Journal, Год журнала: 2024, Номер 17(3), С. 100889 - 100889

Опубликована: Март 1, 2024

BackgroundFood allergies are serious and potentially life-threatening, often place a large burden on patients their caregivers, including impacts quality of life.ObjectiveTo assess the real-world patient food allergies, using self-reported data available from Food Allergy Research & Education (FARE) Patient Registry (NCT04653324).MethodsThe FARE is voluntary captures experiences adults pediatric in United States, through series surveys assessing health with allergies. Self-reported were descriptively analyzed.ResultsThe study cohort included 5587 allergies; 82% had multiple 62% aged <18 years. About half first diagnosed by an allergist/immunologist (53%), most commonly skin prick test (71%) or serum immunoglobulin E (62%). This analysis found that (most peanut [66%], tree nuts [61%], egg [43%], milk [37%]) impart clinical patients, many whom experience food-related allergic reactions comorbidities. Many experienced >1 reaction per year (42%), 46% experiencing food-induced anaphylaxis. Half all occurred at home. Accidental exposures to allergens 77% patients. The common comorbidities reported atopic dermatitis (48%), asthma (46%), rhinitis (39%). be greater different for versus patients.ConclusionThis disease information contributing Registry, thus providing unique insight into lives States These insights may assist clinicians other public stakeholders management

Язык: Английский

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A practical guide for implementing omalizumab therapy for food allergy

Journal of Allergy and Clinical Immunology, Год журнала: 2024, Номер 153(6), С. 1510 - 1517

Опубликована: Апрель 9, 2024

Язык: Английский

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Serologic measurements for peanut allergy

Annals of Allergy Asthma & Immunology, Год журнала: 2024, Номер 132(6), С. 686 - 693

Опубликована: Янв. 24, 2024

Язык: Английский

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New approaches in childhood IgE-mediated food allergy treatment

Current Opinion in Allergy and Clinical Immunology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Purpose of review This aims to provide an overview the current and future treatment options for children with food allergies (FAs), highlighting latest research findings potential impact these new approaches on improving patients’ caregivers’ quality life. Recent In last decade, many promising have emerged as alternative standard avoidance culprit risk severe accidental reactions. Desensitization through oral immunotherapy has been introduced in clinical settings a therapeutic approach, more recently also omalizumab. addition, routes administration immunotherapy, other biologics, small molecules, probiotics or prebiotics, microbiota transplantation therapy, IGNX001, PVX108 are being investigated. Summary The portfolio available is increasing but several relevant unmet needs remain. brief existing IgE-mediated allergies.

Язык: Английский

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AAAAI–EAACI PRACTALL: Standardizing oral food challenges—2024 Update

Pediatric Allergy and Immunology, Год журнала: 2024, Номер 35(11)

Опубликована: Ноя. 1, 2024

This common statement of the American Academy Allergy, Asthma and Immunology (AAAAI) The European Allergy Clinical (EAACI) provides an update 2012 published guidelines on food challenges. equally address challenges in research clinical settings. They first diagnostic tests which can guide decision to conduct a challenge. Safety is prime, various procedures safety issues as well medications potentially involved are extensively discussed. Challenges suggested be conducted with semi-logarithmic incremental doses based protein content, typically for IgE-mediated allergy intervals 20-30 min between doses. Specific protocols other types reactions such atopic dermatitis or gastrointestinal detailed separately. Proper stopping criteria essential order reduce risk false-positive diagnoses, but also severe reactions. recommend "go on," "stop," "observation." These revised will clearly provide much needed guidance continue evolve new needs field allergy.

Язык: Английский

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Role of biologics in severe food allergy

Current Opinion in Allergy and Clinical Immunology, Год журнала: 2024, Номер 24(3), С. 138 - 143

Опубликована: Март 27, 2024

Purpose of review This examine the dynamic landscape food allergy treatment within context emerging biologics. Our purpose is to comprehensively evaluate potential benefits, challenges, and transformative impact associated with utilization biologics in comparison conventional therapeutic modalities. Recent findings document synthesizes recent scientific investigations various biologics, such as omalizumab, ligelizumab, dupilumab, tezepelumab, providing a nuanced understanding their roles oral immunotherapy, rapid desensitization, overall management. studies clinical trials highlight anti-IgE on allergies, revealing critical dose-related efficacy, facilitation desensitization peanut sustained positive outcomes observed individuals multifood allergies. Summary The use presents groundbreaking approach multifaceted action these agents, along overcome challenges traditional therapies, marks significant advancement. Despite persisting economic constraints need for further safety studies, offer promising avenue improving quality life Ongoing research collaborative efforts are imperative fully realize inherent frontiers.

Язык: Английский

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History of food allergy and where we are today

World Allergy Organization Journal, Год журнала: 2024, Номер 17(5), С. 100912 - 100912

Опубликована: Май 1, 2024

Язык: Английский

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Use of the DEFASE score in research trials

Current Opinion in Allergy and Clinical Immunology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Purpose of review To explore the potential applicability in clinical trials groundbreaking international consensus named DEFASE (DEfinition Food Allergy SEverity) as unique grading system for IgE-mediated food allergy (FA) severity embracing different aspects disease a holistic approach. Herein, we discuss its relevance and applications research settings through few scenarios. Recent findings The score has been developed to be used comprehensive scoring system. Researchers are currently focusing on internal external validation system, targeting these models various allergenic sources, populations, settings. Summary Implementing could improve patient stratification, guide therapeutic decisions, support regulatory assessments. Future will focus integration with biomarker data refine predictive accuracy make this tool applicable near future.

Язык: Английский

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Common data elements for food allergy clinical trials: an overview

Current Opinion in Allergy and Clinical Immunology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Purpose of review Food allergy represents a major public health issue, affecting about 8% children and 11% adults in the United States. Research field has rapidly expanded but is limited by lack standardized data fields or common elements (CDEs) to record food data. The present focuses on need for developing CDEs allergy, their anticipated impact, as well describes central tenets CDEs. Recent findings Standardization definitions consistency collection within study across multiple studies fundamental principle clinical research. Several NIH centers have been collaborating support development CDEs, thereby promoting FAIR principles Summary population burden allergies continues rise absence language documenting research Development implementation needed both nationally globally, better understand reduce this immune-mediated disease. When adopted, these will not only improve interoperability also speed up quality future trials.

Язык: Английский

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