Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis

New England Journal of Medicine, Год журнала: 2025, Номер 392(10), С. 947 - 957

Опубликована: Март 5, 2025

Bacterial vaginosis affects one third of reproductive-aged women, and recurrence is common. Evidence sexual exchange bacterial vaginosis-associated organisms between partners suggests that male-partner treatment may increase the likelihood cure. This open-label, randomized, controlled trial involved couples in which a woman had was monogamous relationship with male partner. In partner-treatment group, received first-line recommended antimicrobial agents partner oral topical (metronidazole 400-mg tablets 2% clindamycin cream applied to penile skin, both twice daily for 7 days). control no (standard care). The primary outcome within 12 weeks. A total 81 were assigned 83 group. stopped by data safety monitoring board after 150 completed 12-week follow-up period because only inferior her modified intention-to-treat population, occurred 24 69 women (35%) group (recurrence rate, 1.6 per person-year; 95% confidence interval [CI], 1.1 2.4) 43 68 (63%) 4.2 CI, 3.2 5.7), corresponded an absolute risk difference -2.6 recurrences person-year (95% -4.0 -1.2; P<0.001). Adverse events treated men included nausea, headache, metallic taste. addition combined therapy resulted lower rate weeks than standard care. (Funded National Health Medical Research Council Australia; StepUp Australian New Zealand Clinical Trials Registry number, ACTRN12619000196145.).

Язык: Английский

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Microbes Saving Lives and Reducing Suffering

Microbial Biotechnology, Год журнала: 2025, Номер 18(1)

Опубликована: Янв. 1, 2025

Язык: Английский

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Sexual transmission of urogenital bacteria: whole metagenome sequencing evidence from a sexual network study

mSphere, Год журнала: 2024, Номер 9(3)

Опубликована: Фев. 15, 2024

ABSTRACT Sexual transmission of the urogenital microbiota may contribute to adverse sexual and reproductive health outcomes. The extent is unclear as prior studies largely investigated specific pathogens. We used epidemiologic data whole metagenome sequencing characterize strain concordance between participants a network study. Individuals who screened positive for genital Chlamydia trachomatis were enrolled referred their contacts from 60–180 days. Snowball recruitment continued up four waves. Vaginal swabs penile urethral collected sequencing. evaluated bacterial using inStrain analysis. defined ≥99.99% average nucleotide identity over ≥50% shared coverage; we putative with <5 single-nucleotide polymorphisms per megabase. Of 138 participants, 74 (54%) female; 120 (87%) had chlamydia; 43 (31%) recruited contacts. identified 115 strain-concordance events among 54 representing 25 species. Seven (6%) including heterosexual Fannyhessea vaginae , Gardnerella leopoldii Prevotella amnii Sneathia sanguinegens vaginalis (one each), Lactobacillus iners female Most (108, 94%) non-contacts, eight connected through 18 crispatus 3 jensenii concordant strains, 14 2 male densely interconnected 52 swidsinskii events. IMPORTANCE Epidemiologic evidence consistently indicates vaginosis (BV) sexually associated be transmitted, though remains subject debate. This study not capable demonstrating BV transmission; however, do provide strain-level metagenomic that strongly supports BV-associated These findings strengthen base ongoing investigations concurrent partner treatment reducing recurrence. Our suggest measuring impact on F. G. P. S. insight into why regimen does or perform well. also observed high degree non-sexual-contact participants. posit this reflect limited dispersal capacity vaginal bacteria coupled individuals’ comembership in regional networks where occur parent child at birth, cohabiting individuals,

Язык: Английский

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Re: Male-partner Treatment to Prevent Recurrence of Bacterial Vaginosis

European Urology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Understanding and Preventing Recurring Bacterial Vaginosis: Important Considerations for Clinicians

International Journal of Women s Health, Год журнала: 2023, Номер Volume 15, С. 1317 - 1325

Опубликована: Авг. 1, 2023

Abstract: Bacterial vaginosis (BV) is the most common vaginal infection worldwide. It associated with an increased risk of acquisition HIV and other sexually transmitted infections (STIs) as well pelvic inflammatory disease adverse birth outcomes. During BV, a polymicrobial biofilm forms on surface mucosa. However, exact etiology BV remains controversial which has impeded significant advances in diagnosis, treatment, prevention. Despite 30-day cure rates approaching 80% BV-infected women treated 7 days oral metronidazole, recurrence within 12 months common. This article provides current review epidemiology, pathogenesis, treatment recurrent for practicing clinicians who commonly see this infection. Regarding management, we focus primarily antimicrobial measures that may be effective. Future areas research field are also discussed. Keywords: bacterial vaginosis, recurrent,

Язык: Английский

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Relationship between Bacterial Vaginosis and Sexually Transmitted Infections: Coincidence, Consequence or Co-Transmission?

Microorganisms, Год журнала: 2023, Номер 11(10), С. 2470 - 2470

Опубликована: Окт. 1, 2023

Sexually transmitted infections (STIs) are a serious global problem, causing disease, suffering, and death. Although bacterial vaginosis (BV) is not considered to be an STI, it may associated with increased risk of contracting wide range STIs. We sought assess the link between different microorganisms involved in STIs BV. A total 290 vaginal swabs from women sent for diagnostic purposes clinical microbiology laboratory Marseille University Public Hospitals were tested by specific qPCR targeting STI-causing Of these swabs, 15.2% (44/290) diagnosed at least one microorganism 17.2% (50/290) The prevalence was significantly higher BV (28%, 14/50) than those without (20.4%, 51/240). co-infections involving two more frequent (18% [8/50] vs. 2% [5/250]; p < 0.001). monoinfections polyinfections lower (8.8% [21/240] 28% [14/50]), 0.001 (5/240) 8% (4/50), = 0.05, respectively). Our data suggest that correlation STI exist, both Further research needed better understand its links

Язык: Английский

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The role of urinary microbiota in primary and recurrent bladder cancer: insights from a propensity score matching study

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Март 14, 2025

Bladder cancer (BCa) is a common urinary malignancy with high recurrence rates in non-muscle invasive bladder (NMIBC), posing significant clinical challenges. Emerging evidence links microbiota to progression; however, their role BCa remains unclear. This study aimed explore differences between primary and recurrent identify potential microbiological markers mechanisms associated recurrence. Urine samples were collected from 170 patients, including 125 Bca(BCa_P) 45 (BCa_R). All underwent 16 S rRNA gene sequencing, data collected, age, sex, body mass index (BMI), smoking history, pathological grade, other biological characteristics. Propensity score matching (1:1 ratio, caliper = 0.02) minimized baseline differences, resulting 39 matched pairs. Microbial diversity was analyzed using α β indices. Differential taxa identified Linear Discriminant Analysis Effect Size (LEfSe), functional pathways predicted Phylogenetic Investigation of Communities by Reconstruction Unobserved States (PICRUSt). Alpha significantly higher BCa_P than BCa_R, particularly Chao1 revealed distinct microbial structures (ADONIS, P 0.004, R² 0.025). At the phylum level, both BCa_R dominated Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, Firmicutes Bacteroidetes lower BCa_R. genus enriched Sphingomonas, Corynebacterium, Capnocytophaga, Massilia, Aquabacterium, while showed levels Aeromonas, Cupriavidus, Bradyrhizobium. Functional predictions glucose metabolism oxidative stress pollutant degradation TCA cycle prominent BCa_P. These findings reveal compositions profiles cases exhibiting reduced enrichment potentially pathogenic communities, highlighting roles tumor progression Registered Chinese Clinical Trial Registry (ChiCTR2300070969) on April 27, 2023.

Язык: Английский

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Prevotella and Gardnerella Are Associated With Treatment Failure Following First-line Antibiotics for Bacterial Vaginosis

The Journal of Infectious Diseases, Год журнала: 2023, Номер 228(5), С. 646 - 656

Опубликована: Июль 7, 2023

Bacterial vaginosis (BV) is a common vaginal dysbiosis that often recurs following first-line antibiotics. We investigated if microbiota composition was associated with BV recurrence.We analyzed samples and data from 121 women who participated in 3 published trials evaluating novel interventions for improving cure, including concurrent antibiotic treatment of regular sexual partners (RSPs). Women diagnosed received antibiotics self-collected swabs pretreatment the day after finishing (immediately posttreatment). 16S rRNA gene sequencing performed on samples. Logistic regression explored associations between recurrence features pre- posttreatment.Sixteen (13% [95% confidence interval {CI}, 8%-21%]) experienced within 1 month treatment. an untreated RSP were more likely to experience than no (P = .008) or .011). A higher abundance Prevotella (adjusted odds ratio [AOR], 1.35 CI, 1.05-1.91]) Gardnerella immediately posttreatment (AOR, 1.23 1.03-1.49]) increased recurrence.Having specific spp prior recommended persistence may contribute high rates recurrence. Interventions target these taxa are required achieve sustained cure.

Язык: Английский

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Penile microbiome: decoding its impact on HIV risk

Current Opinion in HIV and AIDS, Год журнала: 2024, Номер unknown

Опубликована: Июнь 18, 2024

Purpose of review The penile microbiome has been linked to local inflammation and increased risk for sexually transmitted infections, including HIV. This explores recent studies this emerging area HIV research Recent findings male urogenital tract supports multiple distinct niches, where their associated are shaped by abiotic (e.g., oxygen, moisture) biotic host immunity) environmental factors behaviors, particularly sexual activity. In addition, circumcision is a significant drivers genital in both children adults. partner provide new insight into the exchange bacteria concurrent immune changes that may impact risk. Summary microenvironment behaviors Improving our understanding connection between microbiome, inflammation, susceptibility, as well how pro-inflammatory partners inform strategies prevent transmission.

Язык: Английский

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Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial

Cell Reports Medicine, Год журнала: 2024, Номер 5(9), С. 101705 - 101705

Опубликована: Авг. 29, 2024

Язык: Английский

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