Biomedicines,
Год журнала:
2024,
Номер
12(12), С. 2714 - 2714
Опубликована: Ноя. 27, 2024
Cardiovascular
disease
comprises
a
group
of
disorders
affecting
or
originating
within
tissues
and
organs
the
cardiovascular
system;
most,
if
not
all,
will
eventually
result
in
cardiomyocyte
dysfunction
death,
negatively
impacting
cardiac
function.
Effective
models
are
thus
important
for
understanding
crucial
aspects
progression,
while
recent
advancements
stem
cell
biology
have
allowed
use
populations
to
derive
such
models.
These
include
three-dimensional
(3D)
as
cell-based
embryos
(SCME)
well
organoids,
many
which
frequently
derived
from
embryoid
bodies
(EB).
Not
only
can
they
recapitulate
3D
form
function,
but
developmental
programs
governing
self-organization
into
more
complex
well.
Many
different
organoids
SCME
constructs
been
generated
years
recreate
tissue
that
give
rise
its
cellular
composition
unique
morphology.
It
is
purpose
this
narrative
literature
review
describe
summarize
recently
organoid
their
recapitulation
genetic
acquired
disease.
Owing
examined,
focus
on
injury
associated
with
embryonic/fetal
tissues.
Seminars in Cancer Biology,
Год журнала:
2024,
Номер
101, С. 58 - 73
Опубликована: Май 27, 2024
Cancer
is
daunting
pathology
with
remarkable
breadth
and
scope,
spanning
genetics,
epigenetics,
proteomics,
metalobomics
cell
biology.
Cellular
senescence
represents
a
stress-induced
essentially
irreversible
fate
associated
aging
various
age-related
diseases,
including
malignancies.
Senescent
cells
are
characterized
of
morphologic
alterations
metabolic
reprogramming,
develop
highly
active
secretome
termed
as
the
senescence-associated
secretory
phenotype
(SASP).
Since
first
discovery,
has
been
understood
an
important
barrier
to
tumor
progression,
its
induction
in
pre-neoplastic
limits
carcinogenesis.
Paradoxically,
senescent
arising
microenvironment
(TME)
contribute
augmented
therapeutic
resistance.
In
this
article,
we
define
typical
forms
commonly
observed
within
TME
how
functionally
remodel
their
surrounding
niche,
affect
immune
responses
promote
cancer
evolution.
Furthermore,
highlight
recently
emerging
pipelines
senotherapies
particularly
senolytics,
which
can
selectively
deplete
from
affected
organs
vivo
impede
progression
by
restoring
securing
anticancer
efficacies.
Together,
co-targeting
normal
but
counterparts
holds
potential
achieve
increased
benefits
restrained
disease
relapse
future
clinical
oncology.
Cancer Prevention Research,
Год журнала:
2024,
Номер
17(7), С. 289 - 303
Опубликована: Май 7, 2024
Abstract
Cancer
growth
is
dependent
on
angiogenesis,
the
formation
of
new
blood
vessels,
which
represents
a
hallmark
cancer.
After
this
concept
was
established
in
1970s,
inhibition
tumor
development
and
metastases
by
blocking
neoangiogenic
process
has
been
an
important
approach
to
treatment
tumors.
However,
antiangiogenic
therapies
are
often
administered
when
cancer
already
progressed.
The
key
reducing
burden
prevention.
We
noticed
20
years
ago
that
series
possible
chemopreventive
agents
showed
properties
tested
experimental
models.
This
article
reviews
relevant
advances
understanding
rationale
for
targeting
angiogenesis
therapy,
prevention,
interception
recently
investigated
substances
with
activity
may
be
suitable
such
strategies.
Many
compounds,
either
dietary
derivatives
or
repurposed
drugs,
tools
angioprevention.
Such
molecules
have
favorable
safety
profile
likely
allow
prolonged
duration
necessary
efficient
preventive
strategy.
Recent
evidence
mechanisms
use
described
here
food
derivatives,
including
flavonoids,
retinoids,
triterpenoids,
omega
fatty
acids,
carotenoids
from
marine
microorganisms.
As
examples,
number
epigallocatechin,
resveratrol,
xanthohumol,
hydroxytyrosol,
curcumin,
fenretinide,
lycopene,
fucoxanthin,
as
aspirin,
β
blockers,
renin–angiotensin–aldosterone
inhibitors,
carnitines,
biguanides,
reviewed.
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 7, 2025
Head
and
neck
tumors
represent
a
prevalent
category
of
oral
maxillofacial
malignancies,
posing
significant
therapeutic
prognostic
challenges
due
to
their
complex
anatomical
structure,
tumor
heterogeneity,
resistance
conventional
therapies.
Recent
studies
have
highlighted
the
strong
association
between
progression
neoangiogenesis,
with
angiopoietin
(ANG)
family
playing
central
role
in
this
process.
Comprising
ANG1,
ANG2,
ANG3,
ANG4,
these
factors
regulate
multiple
signaling
pathways
that
promote
cellular
growth,
differentiation,
proliferation,
thereby
driving
angiogenesis
accelerating
growth
metastasis.
Therefore,
comprehensive
investigation
ANG
family's
head
may
offer
critical
insights
into
tumorigenesis
mechanisms
unveil
novel
targets.
Such
research
has
potential
improve
treatment
outcomes
enhance
quality
life
for
patients.
Antioxidants,
Год журнала:
2024,
Номер
13(8), С. 904 - 904
Опубликована: Июль 26, 2024
Radiation-induced
salivary
gland
injury
(RISGI)
is
a
common
complication
of
radiotherapy
in
patients
with
head
and
neck
cancer.
Intragland
expression
the
Sonic
Hedgehog
(Shh)
gene
may
partially
rescue
irradiation
(IR)-induced
hyposalivation
by
preserving
stem/progenitor
cells
parasympathetic
innervation,
maintaining
resident
macrophages,
microvascular
density.
Previous
studies
have
revealed
that
Ad-Rat
Shh
transduction
through
glands
miniature
pigs
can
ameliorate
oxidative
stress-induced
dysfunction
after
radiotherapy.
Changes
parotid
flow
rate
were
analyzed,
tissue
was
collected
at
5
20
weeks
IR.
pathway
vascular
function-related
markers
(vascular
endothelial
growth
factor
(VEGF)
CD31)
stress-related
detected
via
immunohistochemistry,
immunofluorescence,
Western
blotting.
A
stable
Shh-overexpressing
cell
line
generated
from
human
umbilical
vein
(HUVECs)
exposed
to
10
Gy
X-ray
irradiation,
which
proliferation,
senescence,
apoptosis,
function
evaluated.
We
found
intragland
efficiently
alleviated
IR-induced
pig
model.
Our
results
indicate
antioxidative
stress
microvascular-protective
effects
Hh
are
regulated
nuclear
factor-erythroid
2-related
2
(Nrf2).
