MCC in the spotlight: Its dual role in signal regulation and oncogenesis

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111756 - 111756

Опубликована: Март 1, 2025

Язык: Английский

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Angiogenesis and EMT regulators in the tumor microenvironment in lung cancer and immunotherapy

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Дек. 16, 2024

Lung cancer remains the primary cause of cancer-related mortality, with factors such as postoperative tumor recurrence, metastasis, and therapeutic drug resistance exacerbating patient outcomes. Immunotherapy has emerged a transformative approach, challenging conventional treatment paradigms for lung cancer. Consequently, advancing research in immunotherapy is imperative. Recent studies indicate that numerous regulators within microenvironment (TME) drive angiogenesis epithelial-mesenchymal transition (EMT); these processes are interdependent, reciprocal, collectively contribute to progression. Tumor not only supplies adequate oxygen nutrients cellular proliferation but also establishes pathways facilitating metastasis creating hypoxic regions foster resistance. Concurrently, EMT enhances metastatic potential reinforces drug-resistance genes cells, reciprocal relationship angiogenesis. This interplay ultimately results invasion, paper reviews key EMT, examining their impact on progression, investigates whether newly identified could influence treatment, thus offering valuable insights developing future strategies.

Язык: Английский

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Antiangiogenic Potential of Pomegranate Extracts

Plants, Год журнала: 2024, Номер 13(23), С. 3350 - 3350

Опубликована: Ноя. 29, 2024

Pomegranate (Punica granatum L.) has long been recognised for its rich antioxidant profile and potential health benefits. Recent research expanded therapeutic to include antiangiogenic properties, which are crucial inhibiting the growth of tumours other pathological conditions involving aberrant blood vessel formation. This review consolidates current findings on effects pomegranate extracts. We explore impact polyphenols, including ellagic acid, punicalagin, anthocyanins, punicic acid bioactive polysaccharides key angiogenesis-related pathways endothelial cell function. Emphasis is placed these extracts as phytocomplexes rather than isolated compounds. Additionally, we discuss use by-products, such peels seeds, in preparation within a green chemistry circular economy framework, highlighting their value enhancing extract efficacy sustainability. By primarily reviewing vitro vivo preclinical studies, assess how modulate angiogenesis across various disease models adjunctive therapies cancer angiogenesis-driven disorders. also identifies existing knowledge gaps proposes future directions fully elucidate clinical utility applications.

Язык: Английский

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Controversial role of lactoferrin in cancer: A narrative review

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 181, С. 117743 - 117743

Опубликована: Дек. 1, 2024

Lactoferrin (Lf) is a positively charged iron-binding glycoprotein that has piqued the scientific community's interest due to its pleiotropic behavior, exhibiting wide range of biological activities, including antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, and anticancer effects. This narrative review explores current understanding Lf's role in cancer, focusing on endogenously expressed human full-length ΔLf isoforms, effects treatment with exogenous bovine Lf. We evaluated compared mechanisms by which Lf influences tumorigenesis cancer progression, impact key processes such as cell growth, apoptosis, angiogenesis, migration, invasiveness. Notably, action show some divergences, presumably slight structural differences may lead opposing Insights from this comparison help identify new variants enhanced activity. Indeed, both showed substantial activity, prompting researchers investigate their potential utility prevention progression. However, studies have indicated high levels expression be linked increased carcinogenesis metastasis, reflecting intricate context-dependent cancer. Thus, we emphasize need for deeper comprehension biology regulation enhance more targeted therapeutic strategies, encouraging further research area.

Язык: Английский

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Exploring Moroccan Medicinal Plants for Anticancer Therapy Development Through In Silico Studies

Pharmaceuticals, Год журнала: 2024, Номер 17(11), С. 1528 - 1528

Опубликована: Ноя. 13, 2024

Angiogenesis is a crucial process in the growth and proliferation of cancer, enabling tumor through formation new vasculature supply nutrients oxygen to growing malignant cells. This disease-promoting can be targeted inhibition tyrosine kinase enzymes.

Язык: Английский

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Significant roles of RNA 5-methylcytosine methylation in cancer

Cellular Signalling, Год журнала: 2024, Номер 126, С. 111529 - 111529

Опубликована: Ноя. 28, 2024

Язык: Английский

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