Current Opinion in Infectious Diseases,
Год журнала:
2023,
Номер
36(5), С. 385 - 393
Опубликована: Июль 18, 2023
Purpose
of
review
The
successes
the
coronavirus
disease
2019
(COVID-19)
mRNA
vaccines
have
accelerated
development
against
other
respiratory
pathogens.
aim
this
is
to
highlight
COVID-19
vaccine
advances
and
provide
an
update
on
progress
Recent
findings
demonstrated
effectiveness
in
preventing
severe
death.
H7N9
H10N8
avian
influenza
safety
immunogenicity
phase
1
clinical
trials.
Numerous
seasonal
are
1–3
Respiratory
syncytial
virus
(RSV)
progressed
2–3
trials
adults
a
trial
children.
A
combined
human
metapneumovirus
parainfluenza-3
was
found
be
well
tolerated
immunogenic
among
being
conducted
Clinical
combining
antigens
from
multiple
viruses
underway.
Summary
has
rapidly
recent
years.
Promising
candidates
moving
through
pathway
test
their
efficacy
viral
Nucleic Acids Research,
Год журнала:
2023,
Номер
51(6), С. 2529 - 2573
Опубликована: Март 7, 2023
Eighteen
nucleic
acid
therapeutics
have
been
approved
for
treatment
of
various
diseases
in
the
last
25
years.
Their
modes
action
include
antisense
oligonucleotides
(ASOs),
splice-switching
(SSOs),
RNA
interference
(RNAi)
and
an
aptamer
against
a
protein.
Among
targeted
by
this
new
class
drugs
are
homozygous
familial
hypercholesterolemia,
spinal
muscular
atrophy,
Duchenne
dystrophy,
hereditary
transthyretin-mediated
amyloidosis,
chylomicronemia
syndrome,
acute
hepatic
porphyria,
primary
hyperoxaluria.
Chemical
modification
DNA
was
central
to
making
out
oligonucleotides.
Oligonucleotide
brought
market
thus
far
contain
just
handful
first-
second-generation
modifications,
among
them
2'-fluoro-RNA,
2'-O-methyl
phosphorothioates
that
were
introduced
over
50
years
ago.
Two
other
privileged
chemistries
2'-O-(2-methoxyethyl)-RNA
(MOE)
phosphorodiamidate
morpholinos
(PMO).
Given
their
importance
imparting
with
high
target
affinity,
metabolic
stability
favorable
pharmacokinetic
-dynamic
properties,
article
provides
review
these
use
therapeutics.
Breakthroughs
lipid
formulation
GalNAc
conjugation
modified
paved
way
efficient
delivery
robust,
long-lasting
silencing
genes.
This
account
state-of-the-art
oligo
hepatocytes.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Сен. 16, 2023
Abstract
Extracellular
vesicles
(EVs)
are
30–150
nm
membrane-bound
naturally
secreted
by
cells
and
play
important
roles
in
intercellular
communication
delivering
regulatory
molecules
such
as
proteins,
lipids,
nucleic
acids
metabolites
to
recipient
cells.
As
natural
nano-carriers,
EVs
possess
desirable
properties
high
biocompatibility,
biological
barrier
permeability,
low
toxicity,
immunogenicity,
making
them
potential
therapeutic
delivery
vehicles.
derived
from
specific
have
inherent
targeting
capacity
towards
cell
types,
which
is
yet
not
satisfactory
enough
for
targeted
therapy
development
needs
be
improved.
Surface
modifications
endow
with
abilities,
significantly
improving
their
efficiency.
Herein,
we
first
briefly
introduce
the
biogenesis,
composition,
uptake
function
of
EVs,
review
cargo
loading
approaches
EVs.
Then,
summarize
recent
advances
surface
engineering
strategies
focusing
on
applications
engineered
therapy.
Altogether,
hold
great
promise
various
cargos,
show
promising
effects
multiple
diseases.
Graphical
Journal of Translational Internal Medicine,
Год журнала:
2023,
Номер
11(4), С. 372 - 381
Опубликована: Дек. 1, 2023
Circular
RNAs
(circRNAs)
are
a
class
of
single-stranded
with
covalently
closed
structures.
Owing
to
their
not
having
3'
or
5'
ends,
circRNAs
highly
durable
and
insusceptible
exonuclease-mediated
degradation.
Moreover,
some
certain
structures
translatable,
making
them
novel
vaccines.
Vaccines
efficient
tools
for
immunotherapy,
such
as
the
prevention
infectious
diseases
cancer
treatment.
The
immune
system
is
activated
during
immunotherapy
fight
against
abnormal
allies
invaders.
CircRNA
vaccines
represent
potential
new
avenue
in
vaccine
era.
Recently,
several
circRNA
have
been
synthesized
tested
vitro
vivo.
Our
review
briefly
introduces
current
understanding
biology
function
translatable
circRNAs,
molecular
biology,
synthetic
methods,
delivery
circRNA,
We
also
discussed
challenges
future
directions
field
by
summarizing
developments
past
few
years.
Vaccines,
Год журнала:
2024,
Номер
12(2), С. 191 - 191
Опубликована: Фев. 13, 2024
Vaccines
are
essential
tools
to
prevent
infection
and
control
transmission
of
infectious
diseases
that
threaten
public
health.
Most
agents
enter
their
hosts
across
mucosal
surfaces,
which
make
up
key
first
lines
host
defense
against
pathogens.
Mucosal
immune
responses
play
critical
roles
in
provide
durable
better
recall
responses.
Substantial
attention
has
been
focused
on
developing
effective
vaccines
elicit
robust
localized
systemic
by
administration
via
routes.
yield
protection
superior
parenterally
delivered
vaccines.
Beyond
valuable
immunogenicity,
can
be
less
expensive
easier
administer
without
a
need
for
injection
materials
more
highly
trained
personnel.
However,
faces
many
challenges,
much
effort
directed
at
development.
In
this
article,
we
review
the
history
vaccine
development
present
an
overview
compartment
biology
immunity
plays
defending
infection,
knowledge
helped
inform
We
explore
new
progress
design
optimization
novel
approaches
created
improve
efficacy
safety
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 4, 2024
Abstract
Messenger
RNA
(mRNA)
has
emerged
as
a
promising
therapeutic
molecule
with
numerous
clinical
applications
in
treating
central
nervous
system
disorders,
tumors,
COVID-19,
and
other
diseases.
mRNA
therapies
must
be
encapsulated
into
safe,
stable,
effective
delivery
vehicles
to
preserve
the
cargo
from
degradation
prevent
immunogenicity.
Exosomes
have
gained
growing
attention
because
of
their
good
biocompatibility,
low
immunogenicity,
small
size,
unique
capacity
traverse
physiological
barriers,
cell-specific
tropism.
Moreover,
these
exosomes
can
engineered
utilize
natural
carriers
target
specific
cells
or
tissues.
This
targeted
approach
will
enhance
efficacy
reduce
side
effects
mRNAs.
However,
difficulties
such
lack
consistent
reliable
methods
for
exosome
purification
efficient
encapsulation
large
mRNAs
addressed.
article
outlines
current
breakthroughs
cell-derived
vesicle-mediated
its
biomedical
applications.
Graphical
Vaccines,
Год журнала:
2022,
Номер
10(12), С. 2150 - 2150
Опубликована: Дек. 15, 2022
An
unheard
mobilization
of
resources
to
find
SARS-CoV-2
vaccines
and
therapies
has
been
sparked
by
the
COVID-19
pandemic.
Two
years
ago,
COVID-19’s
launch
propelled
mRNA-based
technologies
into
public
eye.
Knowledge
gained
from
mRNA
technology
used
combat
is
assisting
in
creation
treatments
treat
existing
illnesses
may
avert
pandemics
future.
Exploiting
capacity
create
therapeutic
proteins
impede
or
a
variety
illnesses,
including
cancer,
main
goal
quickly
developing,
highly
multidisciplinary
field
biomedicine.
In
this
review,
we
explore
potential
as
vaccine
using
current
research
findings.
Life,
Год журнала:
2022,
Номер
12(8), С. 1254 - 1254
Опубликована: Авг. 17, 2022
mRNA
vaccines
have
been
revolutionary
in
combating
the
COVID-19
pandemic
past
two
years.
They
also
become
a
versatile
tool
for
prevention
of
infectious
diseases
and
treatment
cancers.
For
effective
vaccination,
formulation,
delivery
method
composition
carrier
play
an
important
role.
can
be
delivered
using
lipid
nanoparticles,
polymers,
peptides
or
naked
mRNA.
The
vaccine
efficacy
is
influenced
by
appropriate
materials,
formulation
methods
selection
proper
administration
route.
In
addition,
co-delivery
several
mRNAs
could
beneficial
enhance
immunity
against
various
variants
pathogen
pathogens
altogether.
Here,
we
review
recent
progress
methods,
modes
patentable
technologies.
