Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер 1871(5), С. 167785 - 167785
Опубликована: Март 7, 2025
Язык: Английский
Frontiers in Genetics, Год журнала: 2023, Номер 14
Опубликована: Ноя. 29, 2023
Colorectal cancer (CRC) is one of the main fatal cancers. Cell signaling such as Janus kinase/signal transducer and activator transcription (JAK/STAT) substantially influences process gene expression cell growth. Long non-coding RNAs (lncRNAs) play regulatory roles in signaling, proliferation, fate. Hence, lncRNAs can be considered biomarkers The inhibitory or activating effects different on JAK/STAT pathway regulate proliferation tumor suppression. Additionally, immune responses which a role immunotherapy. Mechanisms CRC via regulation mainly include invasion, metastasis, apoptosis, adhesion, control inflammation. More profound findings are warranted to specifically target terms activation suppression hindering proliferation. Here, understand lncRNA cross-talk through pathway, we collected related vitro vivo data. Future insights may pave way for development novel diagnostic tools, therapeutic interventions, personalized treatment strategies patients.
Язык: Английский
Процитировано
48
Drug Resistance Updates, Год журнала: 2024, Номер 77, С. 101126 - 101126
Опубликована: Авг. 6, 2024
Язык: Английский
Процитировано
29
CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(4)
Опубликована: Апрель 1, 2024
Abstract The etiology of epilepsy is ascribed to the synchronized aberrant neuronal activity within brain. Circular RNAs (circRNAs), a class non‐coding characterized by their circular structures and covalent linkage, exert substantial influence on this phenomenon. CircRNAs possess stereotyped replication, transience, repetitiveness, paroxysm. Additionally, MicroRNA (miRNA) plays crucial role in regulation diverse pathological processes, including epilepsy. CircRNA particular significance due its ability function as competing endogenous RNA, thereby sequestering or inhibiting miRNA through binding target mRNA. Our review primarily concentrates elucidating functional roles, well underlying mechanisms, circRNA–miRNA–mRNA networks it explores potential utility these for early detection therapeutic intervention.
Язык: Английский
Процитировано
19
Nature Reviews Genetics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
9
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Март 19, 2024
Introduction: Despite the abundance of research indicating participation immune cells in prostate cancer development, establishing a definitive cause-and-effect relationship has proven to be difficult undertaking. Methods: This study employs Mendelian randomization (MR), leveraging genetic variables related from publicly available genome-wide association studies (GWAS), investigate this association. The primary analytical method used is inverse variance weighting (IVW) analysis. Comprehensive sensitivity analyses were conducted assess heterogeneity and horizontal pleiotropy results. Results: identifies four cell traits as causally contributing risk, including CD127- CD8+ T %CD8+ (OR = 1.0042, 95%CI:1.0011–1.0073, p 0.0077), CD45RA on CD39+ resting CD4 regulatory 1.0029, 95%CI:1.0008–1.0050, 0.0065), CD62L− Dendritic Cell Absolute Count 1.0016; 95%CI:1.0005–1.0026; 0.0039), CX3CR1 CD14+ CD16− monocyte 1.0024, 95%CI:1.0007–1.0040, 0.0060). Additionally, two are identified protective factors: 0.9975, 95%CI:0.9958–0.9992, 0.0047), FSC-A plasmacytoid 0.9983, 95%CI:0.9970–0.9995, 0.0070). Sensitivity indicated no pleiotropy. Discussion: Our MR provide evidence for causal between cancer, holding implications clinical diagnosis treatment.
Язык: Английский
Процитировано
16
Cancer Letters, Год журнала: 2024, Номер 592, С. 216907 - 216907
Опубликована: Апрель 27, 2024
Язык: Английский
Процитировано
13
Expert Review of Vaccines, Год журнала: 2024, Номер 23(1), С. 570 - 583
Опубликована: Май 11, 2024
The mRNA vaccine technologies have progressed rapidly in recent years. COVID-19 pandemic has accelerated the application of vaccines, with research and development clinical trials underway for many vaccines. Application quality by design (QbD) framework to establishing standardized control protocols vaccines are essential continued high-quality
Язык: Английский
Процитировано
13
Vacunas, Год журнала: 2025, Номер unknown, С. 500391 - 500391
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
2
Molecular Oncology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Nasopharyngeal carcinoma (NPC) is a kind of malignant tumor with high metastasis. Circular RNAs (circRNAs) are involved in progression, but their functions and mechanisms not well understood. Vasculogenic mimicry (VM) has been discovered as an alternative way to supply nutrition accelerate including NPC. We previously found that circCCNB1 (derived from cyclin B1) could inhibit the migration invasion NPC cells by binding nuclear factor 90 (NF90), however, whether additional biological still unclear. In this study, effects NF90 on generation miR‐15b‐5p miR‐7‐1‐3p were detected using qRT‐PCR, western blotting, RNA pulldown, ribonucleoprotein immunoprecipitation truncated experiments. VM formation assays used assess functions. promoted processing through competitive NF90, thereby inhibiting expression calumenin (CALU), kinesin family member 1B (KIF1B), polymerase III subunit G (POLR3G), ultimately decreasing cells. This study only reveals new function NPC, also provides insights for targeting angiogenesis therapy.
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3055 - 3055
Опубликована: Март 26, 2025
Non-coding RNAs (ncRNAs) are a class of that largely lack the capacity to encode proteins. They have garnered significant attention due their central regulatory functions across numerous cellular and physiological processes at transcriptional, post-transcriptional, translational levels. Over past decade, ncRNA-based therapies gained considerable in diagnosis, treatment, prevention diseases, many studies revealed relationship between ncRNAs diseases. At same time, tissue specificity, an increasing number projects focused on application as biomarkers well design development novel vaccines for clinical use. These may also drive research into potential molecular mechanisms complex pathogenesis related However, new need be validated effectiveness. Additionally, produce safe stable RNA products, factors such purity, precise dosage, effective delivery methods must ensured achieve optimal bioactivity. challenges remain key issues ncRNAs. This review summarizes prospects biomarkers, current status applications vaccines, discusses expectations disease diagnosis drug therapy.
Язык: Английский
Процитировано
1