Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort

The Lancet Child & Adolescent Health, Год журнала: 2023, Номер 7(8), С. 532 - 543

Опубликована: Июнь 16, 2023

Язык: Английский

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The pediatric buccal epigenetic clock identifies significant ageing acceleration in children with internalizing disorder and maltreatment exposure

Neurobiology of Stress, Год журнала: 2021, Номер 15, С. 100394 - 100394

Опубликована: Сен. 11, 2021

Studies reporting accelerated ageing in children with affective disorders or maltreatment exposure have relied on algorithms for estimating epigenetic age derived from adult samples. These limited validity estimation during early development. We here use a pediatric buccal (PedBE) clock to predict DNA methylation-based deviation and without internalizing disorder assess the moderating effect of exposure. further conduct gene set enrichment analysis contribution glucocorticoid signaling PedBE clock-based results.DNA was isolated saliva 158 [73 girls, 85 boys; mean (SD) = 4.25 (0.8) years] including Epigenetic estimated based methylation across 94 CpGs clock. Residuals regressed against chronological were contrasted between disorder. Maltreatment coded 3 severity levels entered moderation model. Genome-wide dexamethasone-responsive an independent sample these within identified.Children exhibited significant acceleration as compared (F1,147 6.67, p .011). This association significantly moderated by (b 0.49, 95% CI [0.073, 0.909], t 2.322, .022). Children who had experienced relative no (1-2 categories: b 0.50, [0.170, 0.821], 3.008, .003; more 0.99, [0.380, 1.593], 3.215, .002). not exposed did show acceleration. There (OR 4.36, 1.65*10-6). Among clock, 18 (19%) responsive dexamethasone.Using novel we that is associated childhood. may, part, be driven glucocorticoids. Identifying developmental drivers after will critical devise targeted interventions.

Язык: Английский

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Prenatal psychological or metabolic stress increases the risk for psychiatric disorders: the “funnel effect” model

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 136, С. 104624 - 104624

Опубликована: Март 15, 2022

Adverse stressful experiences in utero can redirect fetal brain development, ultimately leading to increased risk for psychiatric disorders. Obesity during pregnancy have similar effects as maternal stress, affecting mental health the offspring. In order explain how outcomes may originate from different prenatal conditions, we propose a "funnel effect" model whereby psychological or metabolic stress triggers same evolutionarily conserved response pathways, increasing vulnerability psychopathology. this context, placenta, which is main mother-fetus interface, appears facilitate such convergence, re-directing "stress" signals fetus. Characterizing converging pathways activated by adverse environmental conditions fundamental assess emergence of signatures major disorders, might enable preventive measures populations, and open up new diagnostics, potentially therapeutic approaches disease prevention promotion already pregnancy.

Язык: Английский

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Canada’s Colonial Genocide of Indigenous Peoples: A Review of the Psychosocial and Neurobiological Processes Linking Trauma and Intergenerational Outcomes

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(11), С. 6455 - 6455

Опубликована: Май 26, 2022

The policies and actions that were enacted to colonize Indigenous Peoples in Canada have been described as constituting cultural genocide. When one considers the long-term consequences from perspective of social environmental determinants health framework, impacts such on physical mental go well beyond loss. This paper addresses key historical current Canadian federal relation well-being Peoples. Far a mere lesson history, connections between colonialist present-day outcomes are evaluated terms transgenerational intergenerational transmission processes, including psychosocial, developmental, environmental, neurobiological mechanisms trauma responses. In addition, while created adverse living conditions for Peoples, resilience perseverance many aspects culture may be maintained through processes.

Язык: Английский

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Childhood maltreatment and DNA methylation: A systematic review

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 147, С. 105079 - 105079

Опубликована: Фев. 9, 2023

Язык: Английский

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Transmission of the adverse consequences of childhood maltreatment across generations: Focus on gestational biology

Pharmacology Biochemistry and Behavior, Год журнала: 2022, Номер 215, С. 173372 - 173372

Опубликована: Март 5, 2022

Childhood maltreatment (CM) has well-established consequences for the mental and physical health of exposed individual. Accumulating evidence now suggests that detrimental sequelae CM may be transmitted from one generation to next, thereby extending long-term ramifications early adverse experiences constituting intergenerational continuity in poor outcomes. In this review, current state knowledge on effects maternal exposure is summarized transmission pathways are discussed, specifically direct as well indirect involving variation gestational biology. The review begins with a definition an overview clinical neurobiological offspring generation. intrauterine period biology identified potential time window mechanism transmission, respectively. Furthermore, summary available supporting both biological development included. Finally, gaps challenges investigation role mechanisms addressed considerations future study designs along our studies provided.

Язык: Английский

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Individual longitudinal changes in DNA-methylome identify signatures of early-life adversity and correlate with later outcome

Neurobiology of Stress, Год журнала: 2024, Номер 31, С. 100652 - 100652

Опубликована: Май 31, 2024

Adverse early-life experiences (ELA) affect a majority of the world's children. Whereas enduring impact ELA on cognitive and emotional health is established, there are no tools to predict vulnerability consequences in an individual child. Epigenetic markers including peripheral-cell DNA-methylation profiles may encode provide predictive outcome markers, yet interindividual variance human genome rapid changes DNA methylation childhood pose significant challenges. Hoping mitigate these challenges we examined relation several dimensions using within-subject longitudinal design high methylation-change threshold. was analyzed buccal swab / saliva samples collected twice (neonatally at 12 months) 110 infants. We identified CpGs differentially methylated across time for each child determined whether they associated with indicators executive function age 5. assessed sex differences derived sex-dependent 'impact score' based sites that most contributed changes. Changes between two reflected age-related trends correlated years later. Among tested life factors income needs ratios, maternal sensitivity, body mass index infant sex, unpredictability parental household signals strongest predictor function. In girls, interacted presage Thus, longitudinal, signature potential marker outcome.

Язык: Английский

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Assessing How Social Exposures Are Integrated in Exposome Research: A Scoping Review

Environmental Health Perspectives, Год журнала: 2022, Номер 130(11)

Опубликована: Ноя. 1, 2022

Background: Exposome research aims to describe and understand the extent which all exposures in human environments may affect our health over lifetime. However, way humans interact with their environment is socially patterned. Failing account for social factors exploring exposome underestimate magnitude of effect or mask inequalities distribution both outcomes. Objectives: We aimed appear literature, manner they are used empirical analyses statistical modeling, considered overall scientific approach. Methods: conducted a scoping review literature using three databases (PubMed, Embase, Web Science) up January 2022. grouped studies based on variables were quantified type frequency mentioned articles. also qualitatively described approach by authors integrate variables. Results: screened 1,001 records, 73 included analysis. Fifty-five (∼75%) as confounders both, wide array represented Individual-level more often found, especially education race/ethnicity, well neighborhood-level deprivation indices. Half hypothesis-free other half, hypothesis-driven latter group, 35 studies, only 8 reported discussed at least one possible mechanism underlying relationship observed between variable outcome. Discussion: Social should be systematic way, considering role structuring specific external internal exposome. Doing so could help mechanisms construction and, potentially, alleviate mitigate emergence new ones. https://doi.org/10.1289/EHP11015

Язык: Английский

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A lifetime perspective on risk factors for cognitive decline with a special focus on early events

Cerebral Circulation - Cognition and Behavior, Год журнала: 2024, Номер 6, С. 100217 - 100217

Опубликована: Янв. 1, 2024

Both Alzheimer's disease and vascular dementia are the result of processes that typically develop over several decades. Population studies have estimated more than half risk for is preventable or at least modifiable through behavioral adaptations. The association between these lifestyle factors most evident exposure in midlife. However, habits formed middle age often reflect a lifetime behavior patterns living conditions. Therefore, individuals who, example, able to maintain healthy diets regular exercise during their years likely benefit from cognition-protective they practiced throughout lives. For numerous adult diseases, significant risks can be traced back early childhood. Suboptimal conditions perinatal period, childhood adolescence increase including stroke, heart disease, insulin resistance, hypertension dementia. This review aims summarizing some evidence life-time perspective with goal raising awareness prevention successful aging.

Язык: Английский

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Epigenetics as a Biomarker for Early-Life Environmental Exposure

Current Environmental Health Reports, Год журнала: 2022, Номер 9(4), С. 604 - 624

Опубликована: Июль 30, 2022

Язык: Английский

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