Prevalence of mental disorders in people living with type 1 diabetes: A systematic literature review and meta-analysis

General Hospital Psychiatry, Год журнала: 2022, Номер 80, С. 1 - 16

Опубликована: Ноя. 25, 2022

Type 1 diabetes is associated with increased prevalence of individual categories mental disorders. We aimed to systematically synthesise the all different disorders estimate overall burden psychiatric morbidity in type population.The electronic database OVID was searched, and retrieved papers were screened for eligibility by two independent reviewers. Data extracted using a standardised data extraction form quality included assessed. Where possible, comparisons control groups without made. Prevalence synthesised into Diagnostic Statistical Manual Mental Disorders version 5 categories, narrative data-synthesis, subsequent meta-analysis where possible conducted disorder categories.Thirty-eight articles included. Depressive, anxiety, feeding eating most examined Studies utilising diagnostic interviews reported higher than studies clinical registers, an up 24-fold difference respectively. In group, nearly every samples.There appears be high need among people diabetes, although research needs improve.This protocol submitted registration International Prospective Register Systematic Reviews (PROSPERO) (CRD42020221530).

Язык: Английский

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Cadmium perturbed metabolomic signature in pancreatic beta cells correlates with disturbed metabolite profile in human urine

Environment International, Год журнала: 2022, Номер 161, С. 107139 - 107139

Опубликована: Фев. 13, 2022

Cd exposure has been demonstrated to induce a variety of metabolic disorders accompanied with imbalance glucose and lipid homeostasis. The toxicity at metabolome-wide level remains elusive. In our study, we that via drinking water increased blood levels, decreased serum insulin led intolerance suppressed expression in the pancreas C57/6J mice. significantly inhibited cell viability secretion MIN6 cells vitro. Since pancreatic β-cells are only source production body play pivotal role modulating metabolisms, further delineated metabolomic signatures insulin-secreting by using non-target metabolomics. PCA OPLS-DA analysis clearly suggested marked alteration cells. 76 perturbed metabolites were identified after exposure. Classification belong nucleosides, nucleotides analogues, organic acids derivatives, lipids lipid-like molecules. 28 existed mitochondrion, suggesting mitochondrion as major target organelle KEGG pathway revealed 20 pathways disturbed Mitochondrial TCA cycle glycerophospholipid metabolism remarkably disturbed. mRNA expressions genes mitochondrial fatty acid oxidation dysregulated Disturbances result producing β-cells. Moreover, 14 co-existed urine exposed workers. 11 biomarkers diabetes mellitus also found be altered conclusion, findings this study greatly extend understanding offer some new clues for linking development mellitus. Results support notion induced could monitored examining urinary humans highlight significance reducing population level.

Язык: Английский

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Association Between Type 1 Diabetes Mellitus and Celiac Disease: Autoimmune Disorders With a Shared Genetic Background

Cureus, Год журнала: 2022, Номер unknown

Опубликована: Март 7, 2022

Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are one of the most recognized related autoimmune disorders as they share a common genetic background that has been found in HLA genotype, more specifically DQ2 DQ8 molecules. Studies have shown environmental factors early or late exposure to cereals first months life acquired viral infections implicated risk development autoantigens. CD, cases, is asymptomatic; therefore, it goes underdiagnosed. As result, linked consequences decreased growth, delayed puberty, anemia. Also, CD considered an independent factor for nephropathy retinopathy. Therefore, T1DM patients, high-risk individuals, screening recommended, especially analyze their joint management. A gluten-free diet studied possible benefits glycemic control decreasing hypoglycemic episodes preventing bowel mucosal damage gluten well documented primary trigger these responses. This article reviewed concurrent occurrence regarding pathogenesis, clinical overlaps, screening, management options.

Язык: Английский

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The pharmacology and therapeutic role of cannabidiol in diabetes

Exploration, Год журнала: 2023, Номер 3(5)

Опубликована: Июль 12, 2023

Abstract In recent years, cannabidiol (CBD), a non‐psychotropic cannabinoid, has garnered substantial interest in drug development due to its broad pharmacological activity and multi‐target effects. Diabetes is chronic metabolic disease that can damage multiple organs the body, leading of complications such as abnormal kidney function, vision loss, neuropathy, cardiovascular disease. CBD demonstrated significant therapeutic potential treating diabetes mellitus owing various This work summarizes role impact on dysfunction, nephropathy, retinopathy, neuropathy. Strategies for discovering molecular targets treatment are also proposed. Moreover, ways optimize structure based known generate new analogues explored.

Язык: Английский

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The potential of astragalus polysaccharide for treating diabetes and its action mechanism

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 10, 2024

Type 2 diabetes presents a significant global health burden and is frequently linked to serious clinical complications, including diabetic cardiomyopathy, nephropathy, retinopathy. Astragalus polysaccharide (APS), extracted from

Язык: Английский

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