Journal of Fungi,
Год журнала:
2024,
Номер
10(2), С. 134 - 134
Опубликована: Фев. 7, 2024
The
potential
of
Stropharia
rugosoannulata
as
a
microbial
remediation
material
for
cadmium
(Cd)-contaminated
soil
lies
in
its
capacity
to
absorb
and
accumulate
Cd
mycelia.
This
study
utilized
the
TMT
LC−MS
techniques
conduct
integrated
proteomic
metabolomic
analyses
with
aim
investigating
mycelial
response
mechanisms
S.
under
low-
high-Cd
stresses.
results
revealed
that
mycelia
employed
proactive
defense
mechanism
maintain
their
physiological
functions,
leading
reduced
sensitivity
low-Cd
stress.
ability
withstand
high
levels
stress
was
influenced
primarily
by
comprehensive
regulation
six
metabolic
pathways,
which
led
harmonious
balance
between
nitrogen
carbohydrate
metabolism
reductions
oxidative
growth
inhibition
caused
Cd.
provide
valuable
insights
into
molecular
involved
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 20, 2023
Metabolic
abnormalities
lead
to
the
dysfunction
of
metabolic
pathways
and
metabolite
accumulation
or
deficiency
which
is
well-recognized
hallmarks
diseases.
Metabolite
signatures
that
have
close
proximity
subject's
phenotypic
informative
dimension,
are
useful
for
predicting
diagnosis
prognosis
diseases
as
well
monitoring
treatments.
The
lack
early
biomarkers
could
poor
serious
outcomes.
Therefore,
noninvasive
methods
with
high
specificity
selectivity
desperately
needed.
Small
molecule
metabolites-based
metabolomics
has
become
a
specialized
tool
biomarker
pathway
analysis,
revealing
possible
mechanisms
human
various
deciphering
therapeutic
potentials.
It
help
identify
functional
related
variation
delineate
biochemical
changes
indicators
pathological
damage
prior
disease
development.
Recently,
scientists
established
large
number
profiles
reveal
underlying
networks
target
exploration
in
biomedicine.
This
review
summarized
analysis
on
potential
value
small-molecule
candidate
metabolites
clinical
events,
may
better
diagnosis,
prognosis,
drug
screening
treatment.
We
also
discuss
challenges
need
be
addressed
fuel
next
wave
breakthroughs.
Poultry Science,
Год журнала:
2024,
Номер
103(7), С. 103817 - 103817
Опубликована: Май 1, 2024
Cadmium
(Cd)
is
a
common
environmental
pollutant
associated
with
an
increased
incidence
of
renal
metabolic
diseases.
Luteolin
(Lut),
natural
flavonoid,
widely
used
for
its
multifaceted
therapeutic
properties
in
inflammatory
However,
whether
Lut
protects
against
Cd-induced
nephrotoxicity
still
equivocal.
The
present
study
investigated
the
effects
supplementation
on
oxidative
stress,
inflammation
and
metabolism
their
related
mechanisms.
Therefore,
40
chickens
were
treated
Cd
and/or
automatic
water
free
food
intake
1
mo
then
kidney
tissues
collected
to
explore
this
issue.
In
study,
exposure
induced
glycolipid
disorders
resultant
damage
by
periodic
acid
Schiff
(PAS)
staining,
Oil
Red
O
total
cholesterol
(TC),
triglyceride
(TG),
glucose
(Glu)
levels
kidney,
which
significantly
ameliorated
Lut.
Moreover,
also
normalized
expression
factors
Cd-disturbed
metabolism,
improving
homeostasis,
contributing
alleviating
damage.
Furthermore,
demonstrated
potential
stress
enhancing
antioxidant
capacity
inhibiting
cytokine
production
tissues.
Mechanistically,
activated
AMPK/SIRT1/FOXO1
signaling
pathway,
attenuating
responses,
ameliorating
disturbance.
conclusion,
these
observations
demonstrate
that
treatment
activates
decreases
response,
may
contribute
prevent
disorder
consequent
Toxics,
Год журнала:
2023,
Номер
11(8), С. 670 - 670
Опубликована: Авг. 3, 2023
Metabolic
syndrome
(MetS)
is
an
important
public
health
issue
that
affects
millions
of
people
around
the
world
and
growing
to
pandemic-like
proportions.
This
defined
by
World
Health
Organization
(WHO)
as
a
pathologic
condition
characterized
abdominal
obesity,
insulin
resistance,
hypertension,
hyperlipidemia.
Moreover,
etiology
MetS
multifactorial,
involving
many
environmental
factors,
including
toxicant
exposures.
Several
studies
have
associated
with
heavy
metals
exposure,
which
focus
this
review.
Environmental
and/or
occupational
exposure
are
major
risk,
contributing
development
chronic
diseases.
Of
particular
note,
toxic
such
mercury,
lead,
cadmium
may
contribute
altering
oxidative
stress,
IL-6
signaling,
apoptosis,
altered
lipoprotein
metabolism,
fluid
shear
stress
atherosclerosis,
other
mechanisms.
In
review,
we
discuss
known
potential
roles
in
well
targeted
pathways
MetS.
Furthermore,
describe
how
new
approaches
proteomic
transcriptome
analysis,
bioinformatic
tools,
help
bring
about
understanding
involvement
metalloids
