International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9776 - 9776
Опубликована: Сен. 10, 2024
Changes
in
maternal
gut
microbiota
due
to
stress
and/or
ethanol
exposure
can
have
lasting
effects
on
offspring’s
health,
particularly
regarding
immunity,
inflammation
response,
and
susceptibility
psychiatric
disorders.
The
literature
search
for
this
review
was
conducted
using
PubMed
Scopus,
employing
keywords
phrases
related
stress,
exposure,
microbiota,
microbiome,
gut–brain
axis,
diet,
dysbiosis,
progesterone,
placenta,
prenatal
development,
inflammation,
depression
identify
relevant
studies
both
preclinical
human
research.
Only
a
limited
number
of
reviews
were
included
support
the
arguments.
encompassed
from
1990s
present.
This
begins
by
exploring
role
modulating
host
health
disease.
It
then
examines
how
disturbances
affect
immune
system.
analysis
continues
investigating
interplay
between
focusing
influences
offspring
its
implications
depression.
also
considers
impact
consumption
with
an
emphasis
microbiota.
Finally,
it
is
suggested
that
dysbiosis
may
be
significantly
exacerbated
combined
leading
system
dysfunction
chronic
which
could
increase
risk
offspring.
These
interactions
underscore
potential
novel
mental
interventions
address
especially
relation
health.
Journal of Personalized Medicine,
Год журнала:
2023,
Номер
13(7), С. 1078 - 1078
Опубликована: Июнь 29, 2023
The
fight
against
suicide
is
highly
challenging
as
it
may
be
one
of
the
most
complex
and,
at
same
time,
threatening
among
all
psychiatric
phenomena.
In
spite
its
huge
impact,
and
despite
advances
in
neurobiology
research,
understanding
predicting
remains
a
major
challenge
for
both
researchers
clinicians.
To
able
to
identify
those
patients
who
are
likely
engage
suicidal
behaviors
risk
reliable
timely
manner,
we
need
more
specific,
novel
biological
genetic
markers/indicators
develop
better
screening
diagnostic
methods,
next
step
utilize
these
molecules
intervention
targets.
One
such
potential
approach
offered
by
our
increasing
involvement
neuroinflammation
based
on
multiple
observations
increased
proinflammatory
states
underlying
various
disorders,
including
behavior.
present
paper
overviews
existing
association
between
inflammation,
peripheral
central
biomarkers,
genomic
markers,
current
knowledge
using
treatments
influencing
inflammation;
also
overviewing
steps
taken
obstacles
overcome
before
can
cytokines
treatment
Psychiatry Research,
Год журнала:
2024,
Номер
339, С. 116085 - 116085
Опубликована: Июль 16, 2024
In
this
study,
we
aimed
to
investigate
the
associations
between
recurrence
of
illness
(ROI)
and
biomarkers
related
an
activated
immune
network,
immune-linked
neurotoxicity
(INT),
a
combined
INT
atherogenicity
index
(METAMMUNE).
The
study
involved
67
healthy
controls
66
outpatient
MDD
(OMDD)
participants.
We
utilized
Multiplex
method
measure
48
cytokines
examined
METAMMUNE
composite
scores
in
association
with
different
ROI
indices.
Our
findings
revealed
that
was
successfully
created
by
extracting
validated
principal
component,
from
physician-rated
or
self-declared
number
depressive
episodes,
frequency
lifetime
suicidal
ideation
attempts.
significantly
associated
indices,
neuroticism,
current
behaviors,
phenome.
analysis
also
significant
portion
variance
OMDD
phenome,
which
includes
anxiety,
depression,
can
be
accounted
for
regression
on
INT,
ROI,
emotional
neglect
abuse.
A
latent
construct
extracted
three
components,
results
indicate
increasing
indicates
heightened
immune-metabolic
abnormalities,
increased
risk
elevated
severity
phenome
features.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9776 - 9776
Опубликована: Сен. 10, 2024
Changes
in
maternal
gut
microbiota
due
to
stress
and/or
ethanol
exposure
can
have
lasting
effects
on
offspring’s
health,
particularly
regarding
immunity,
inflammation
response,
and
susceptibility
psychiatric
disorders.
The
literature
search
for
this
review
was
conducted
using
PubMed
Scopus,
employing
keywords
phrases
related
stress,
exposure,
microbiota,
microbiome,
gut–brain
axis,
diet,
dysbiosis,
progesterone,
placenta,
prenatal
development,
inflammation,
depression
identify
relevant
studies
both
preclinical
human
research.
Only
a
limited
number
of
reviews
were
included
support
the
arguments.
encompassed
from
1990s
present.
This
begins
by
exploring
role
modulating
host
health
disease.
It
then
examines
how
disturbances
affect
immune
system.
analysis
continues
investigating
interplay
between
focusing
influences
offspring
its
implications
depression.
also
considers
impact
consumption
with
an
emphasis
microbiota.
Finally,
it
is
suggested
that
dysbiosis
may
be
significantly
exacerbated
combined
leading
system
dysfunction
chronic
which
could
increase
risk
offspring.
These
interactions
underscore
potential
novel
mental
interventions
address
especially
relation
health.
