Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Advanced Materials, Год журнала: 2021, Номер 33(39)

Опубликована: Июль 12, 2021

With all the advances in tissue engineering for construction of fully functional skin tissue, complete regeneration chronic wounds is still challenging. Since immune reaction to damage critical regulating both quality and duration wound healing cascade, strategies modulate system are importance. Generally, response an injury, macrophages switch from pro-inflammatory anti-inflammatory phenotype. Therefore, controlling macrophages' polarization has become appealing approach regenerative medicine. Recently, hydrogels-based constructs, incorporated with various cellular molecular signals, have been developed utilized adjust cell functions stages healing. Here, current state knowledge on during first discussed. Recent advanced technologies used design immunomodulatory hydrogels then summarized. Rational providing controlled stimulation via hydrogel chemistry surface modification, as well incorporation molecules, also dicussed. In addition, effects hydrogels' properties immunogenic features process Finally, future directions upcoming research control responses highlighted.

Язык: Английский

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Polymeric nanoparticles: the future of nanomedicine

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2015, Номер 8(2), С. 271 - 299

Опубликована: Авг. 28, 2015

Polymeric nanoparticles (NPs) are one of the most studied organic strategies for nanomedicine. Intense interest lies in potential polymeric NPs to revolutionize modern medicine. To determine ideal nanosystem more effective and distinctly targeted delivery therapeutic applications, particle size, morphology, material choice, processing techniques all research areas interest. Utilizations include drug such as conjugation entrapment drugs, prodrugs, stimuli-responsive systems, imaging modalities, theranostics. Cancer, neurodegenerative disorders, cardiovascular diseases fields impacted by NP technologies that push scientific boundaries leading edge transformative advances

Язык: Английский

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The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Chemical Reviews, Год журнала: 2021, Номер 121(3), С. 1746 - 1803

Опубликована: Янв. 14, 2021

Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a decade. Classically, scientists have tried improve NM by employing passive or active targeting strategies, making use so-called enhanced permeability and retention (EPR) effect. This phenomenon is made possible due leaky tumor vasculature through which NMs can leave bloodstream, traverse gaps in endothelial lining vessels, enter tumor. Recent studies shown that despite many efforts employ EPR effect, this process remains very poor. Furthermore, role effect called into question, where it suggested

Язык: Английский

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Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Фев. 28, 2020

Abstract The efficacy of nano-mediated drug delivery has been impeded by multiple biological barriers such as the mononuclear phagocyte system (MPS), well vascular and interstitial barriers. To overcome abovementioned obstacles, we report a nano-pathogenoid (NPN) that can in situ hitchhike circulating neutrophils supplement photothermal therapy (PTT). Cloaked with bacteria-secreted outer membrane vesicles inheriting pathogen-associated molecular patterns native bacteria, NPNs are effectively recognized internalized neutrophils. migrate towards inflamed tumors, extravasate across blood vessels, penetrate through tumors. Then rapidly released from response to inflammatory stimuli subsequently taken up tumor cells exert anticancer effects. Strikingly, due excellent targeting efficacy, cisplatin-loaded combined PTT completely eradicate tumors all treated mice. Such nano-platform represents an efficient generalizable strategy cell hitchhiking enhanced targeted delivery.

Язык: Английский

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Drug Carrier for Photodynamic Cancer Therapy

International Journal of Molecular Sciences, Год журнала: 2015, Номер 16(9), С. 22094 - 22136

Опубликована: Сен. 14, 2015

Photodynamic therapy (PDT) is a non-invasive combinatorial therapeutic modality using light, photosensitizer (PS), and oxygen used for the treatment of cancer other diseases. When PSs in cells are exposed to specific wavelengths they transformed from singlet ground state (S₀) an excited (S₁-Sn), followed by intersystem crossing triplet (T₁). The energy transferred T₁ biological substrates molecular oxygen, via type I II reactions, generates reactive species, (¹O₂, H₂O₂, O₂*, HO*), which causes cellular damage that leads tumor cell death through necrosis or apoptosis. solubility, selectivity, targeting photosensitizers important factors must be considered PDT. Nano-formulating with organic inorganic nanoparticles poses as potential strategy satisfy requirements ideal PDT system. In this review, we summarize several PS carriers have been studied enhance efficacy photodynamic against cancer.

Язык: Английский

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Nanoparticles in Drug Delivery: From History to Therapeutic Applications

Nanomaterials, Год журнала: 2022, Номер 12(24), С. 4494 - 4494

Опубликована: Дек. 19, 2022

Current research into the role of engineered nanoparticles in drug delivery systems (DDSs) for medical purposes has developed numerous fascinating nanocarriers. This paper reviews various conventionally used and current carriage system to deliver drugs. Due drawbacks conventional DDSs, nanocarriers have gained immense interest. Nanocarriers like polymeric nanoparticles, mesoporous nanomaterials, carbon nanotubes, dendrimers, liposomes, metallic nanomedicine, nanomaterials are as targeted at specific sites affected areas body. Nanomedicine rapidly grown treat certain diseases brain cancer, lung breast cardiovascular diseases, many others. These nanomedicines can improve bioavailability absorption time, reduce release eliminate aggregation, enhance solubility blood. introduced a new era by refining therapeutic directories energetic pharmaceutical elements within nanoparticles. In this context, vital information on was reviewed conferred towards ailments. All these were tested vitro vivo. coming years, human health more effectively adding advanced techniques system.

Язык: Английский

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Nanoparticle‐Laden Macrophages for Tumor‐Tropic Drug Delivery

Advanced Materials, Год журнала: 2018, Номер 30(50)

Опубликована: Окт. 11, 2018

Abstract Macrophages hold great potential in cancer drug delivery because they can sense chemotactic cues and home to tumors with high efficiency. However, it remains a challenge load large amounts of therapeutics into macrophages without compromising cell functions. This study reports silica‐based nanocapsule approach solve this issue. The consists drug–silica complex filling solid silica sheath, is designed minimally release molecules the early hours entry. While taken up by at rates, nanocapsules affect migration first 6–12 h, buying time for drugs situ. In particular, shown that doxorubicin (Dox) as representative be loaded 16.6 pg per using approach. When tested U87MG xenograft model, intravenously (i.v.) injected Dox‐laden show comparable tumor accumulation untreated macrophages. Therapy leads efficient growth suppression, while causing little systematic toxicity. suggests new platform selective delivery, which readily extended treatment other types diseases.

Язык: Английский

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Molecular Communication and Nanonetwork for Targeted Drug Delivery: A Survey

IEEE Communications Surveys & Tutorials, Год журнала: 2017, Номер 19(4), С. 3046 - 3096

Опубликована: Янв. 1, 2017

Molecular communication (MC) and molecular network (MN) are paradigms that use biochemical signaling to achieve information exchange among naturally artificially synthesized nanosystems. Among the envisaged application areas of MC MN is field nanomedicine, where subject targeted drug delivery (TDD) at forefront. Typically, when someone gets sick, therapeutic drugs administered person for healing purposes. Since no can be effective until it delivered target site in body, different modalities improve sites being explored contemporary research. The most promising these TDD. TDD modality promises a smart localization appropriate dose part body reduced system toxicity. Research has been going on many years medical science; however, translation expectations clinical reality not satisfactorily achieved because several challenges. exploration ideas under considered as an option addressing challenges facilitate from bench patients' bedsides. Over past decade, there have some research efforts made exploring platforms. While number output terms scientific articles few moment, desire community participate realizing goal quite high evidence rise over last years. To increase awareness provide multidisciplinary with necessary background TDD, this paper presents visionary survey within domain MN. We start by introducing elaborate manner, motivation behind study implementation Specifically, explanation how MC-based concepts differ traditional science provided. also summarize taxonomy perspectives through which viewed. System models design challenges/requirements developing discussed. Various metrics used evaluate performance systems highlighted. discussion path activities Finally, we discuss issues such informatics software tools, well border requirement standards regulatory policies practice.

Язык: Английский

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Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Авг. 6, 2021

Abstract Some specific chemotherapeutic drugs are able to enhance tumor immunogenicity and facilitate antitumor immunity by inducing immunogenic cell death (ICD). However, immunosuppression induced the adenosine pathway hampers this effect. In study, E-selectin-modified thermal-sensitive micelles designed co-deliver a drug (doxorubicin, DOX) an A2A receptor antagonist (SCH 58261), which simultaneously exhibit chemo-immunotherapeutic effects when applied with microwave irradiation. After intravenous injection, fabricated effectively adhere surface of leukocytes in peripheral blood mediated E-selectin, thereby hitchhiking achieve higher accumulation at site. Further, local irradiation is induce hyperthermia accelerates release rate from micelles. Rapidly released DOX induces ICD elicits tumor-specific immunity, while SCH 58261 alleviates caused pathway, further enhancing DOX-induced immunity. conclusion, study presents strategy increase leukocytes, synergistic chemo-immunotherapy not only arrested primary growth, but also exhibited superior terms antimetastasis, antirecurrence antirechallenge.

Язык: Английский

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Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Сен. 15, 2022

Besides the broad development of nanotechnological approaches for cancer diagnosis and therapy, currently, there is no significant progress in treatment different types brain tumors. Therapeutic molecules crossing blood-brain barrier (BBB) reaching an appropriate targeting ability remain key challenges. Many invasive non-invasive methods, various nanocarriers their hybrids have been widely explored tumor treatment. However, unfortunately, crucial clinical translations were observed to date. In particular, chemotherapy surgery main methods therapy Exploring mechanisms BBB penetration detail investigating advanced drug delivery platforms are factors that could bring us closer understanding effective against this review, we discuss most relevant aspects mechanisms, observing both delivery. We also review recent functional platforms, from viruses cell-based vehicles, therapy. The destructive potential chemotherapeutic drugs delivered considered. This then summarizes existing challenges future prospects use

Язык: Английский

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