Approaches to Improve Macromolecule and Nanoparticle Accumulation in the Tumor Microenvironment by the Enhanced Permeability and Retention Effect

Polymers, Год журнала: 2022, Номер 14(13), С. 2601 - 2601

Опубликована: Июнь 27, 2022

Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing macromolecules deliver their payload selectively to solid tumors. An important driver of passive enhanced permeability retention (EPR) effect, cornerstone most carrier-based tumor-targeted drug delivery efforts. Despite huge number publications showcasing successes in preclinical animal models, translation clinic has been poor, with only a few nano-based drugs currently being used for treatment cancers. Several barriers factors have adduced low efficiency tumors poor clinical translation, including characteristics macromolecules, vascular physiological barriers, heterogeneity tumor blood supply affects homogenous distribution within tumors, transport penetration depth nanoparticles matrix. To address challenges associated therapeutic efficacy humans, identified that affect effect macromolecular therapeutics nanoparticle systems need be overcome. In this review, approaches facilitate improved EPR outcomes novel are discussed.

Язык: Английский

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Cell-based drug delivery systems and their in vivo fate

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 187, С. 114394 - 114394

Опубликована: Июнь 17, 2022

Язык: Английский

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Advancements in cell membrane camouflaged nanoparticles: A bioinspired platform for cancer therapy

Journal of Controlled Release, Год журнала: 2022, Номер 346, С. 71 - 97

Опубликована: Апрель 21, 2022

Язык: Английский

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Leutusome: A Biomimetic Nanoplatform Integrating Plasma Membrane Components of Leukocytes and Tumor Cells for Remarkably Enhanced Solid Tumor Homing

Nano Letters, Год журнала: 2018, Номер 18(10), С. 6164 - 6174

Опубликована: Сен. 12, 2018

Cell membrane-camouflaged nanoparticles have appeared as a promising platform to develop active tumor targeting nanomedicines. To evade the immune surveillance, we designed composite cell biomimetic nanoplatform, namely, leutusome, which is made of liposomal incorporating plasma membrane components derived from both leukocytes (murine J774A.1 cells) and cells (head neck HN12). Exogenous phospholipids were used building blocks fuse with two membranes form nanoparticles. Liposomal exogenous only or in combination one type fabricated compared. The anticancer drug paclitaxel (PTX) was make drug-encapsulating Leutusome resembling characteristic examined confirmed vitro. A xenograft mouse model head cancer profile blood clearance kinetics, biodistribution, antitumor efficacy different results demonstrated that leutusome obtained prolonged circulation most efficient accumulating at site (79.1 ± 6.6% ID per gram tumor). Similarly, composed fractions B16 melanoma (J774A.1) showed prominent accumulation within tumor, suggesting generalization approach. Furthermore, PTX-encapsulating found potently inhibit growth while not causing systemic adverse effects.

Язык: Английский

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Targeting tumor associated macrophages: The new challenge for nanomedicine

Seminars in Immunology, Год журнала: 2017, Номер 34, С. 103 - 113

Опубликована: Сен. 21, 2017

Язык: Английский

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Responsive Nanocarriers as an Emerging Platform for Cascaded Delivery of Nucleic Acids to Cancer

Advanced Drug Delivery Reviews, Год журнала: 2017, Номер 115, С. 98 - 114

Опубликована: Апрель 7, 2017

Язык: Английский

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Cell-mediated targeting drugs delivery systems

Drug Delivery, Год журнала: 2020, Номер 27(1), С. 1425 - 1437

Опубликована: Янв. 1, 2020

Drug delivery systems have shown tremendous promise to improve the diagnostic and therapeutic effects of drugs due their special property. Targeting tissue damage, tumors, or with limited toxicity at site infection is goal successful pharmaceuticals. Targeted drug has become significantly important in enhancing pharmaceutical reducing side therapeutics treatment various disease conditions. Unfortunately, clinical translation these targeted system mechanisms faces many challenges. At present, only a few can achieve high targeting efficiency after intravenous injection, even though numerous surface markers approaches been developed. Thus, cell-mediated drug-delivery received considerable attention for enhanced specificity efficacy disease. This review highlights recent advances design different types cells that explored mechanisms. A better understanding cell biology orientation new generation strategies utilize endogenous are expected provide solutions specific further facilitate translation.

Язык: Английский

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Cell‐Based Drug Delivery and Use of Nano‐and Microcarriers for Cell Functionalization

Advanced Healthcare Materials, Год журнала: 2017, Номер 7(3)

Опубликована: Ноя. 30, 2017

Abstract Cell functionalization with recently developed various nano‐ and microcarriers for therapeutics has significantly expanded the application of cell therapy targeted drug delivery effective treatment a number diseases. The aim this progress report is to review most recent advances in cell‐based vehicles designed as biological transporter platforms different drugs. For design vehicles, pathways functionalization, such covalent noncovalent surface modifications, internalization carriers are considered greater detail together approaches visualization vivo. In addition, several animal models study cell‐assisted discussed. Finally, possible future developments applications toward transport drugs designated location no or minimal immune response toxicity addressed light new field nanomedicine.

Язык: Английский

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Nanomaterials engineering for drug delivery: a hybridization approach

Journal of Materials Chemistry B, Год журнала: 2017, Номер 5(22), С. 3995 - 4018

Опубликована: Янв. 1, 2017

The last twenty years have witnessed great advances in biology, medicine, and materials science, leading to the development of various nanoparticle (NP)-mediated drug delivery systems. Innovation science has led generation biodegradable, biocompatible, stimuli-responsive, targeted However, currently available nanotherapeutic technologies are not efficient, which culminated failure their clinical trials. Despite huge efforts devoted nanotherapeutics, only a small amount injected material could reach desired target. One promising strategy enhance efficiency NP is hybridize multiple materials, where each component play critical role an efficient multipurpose system. This review aims comprehensively cover different techniques, advantages, drawbacks systems develop hybrid nano-vesicles for delivery. Attention finally given hybridization benefits overcoming biological barriers It believed that advent modern nano-formulations multifunctional carriers paves way future achieve more

Язык: Английский

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Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications and enhanced translational potential

Advanced Drug Delivery Reviews, Год журнала: 2019, Номер 148, С. 146 - 180

Опубликована: Фев. 22, 2019

Язык: Английский

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