Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation

Bioactive Materials, Год журнала: 2023, Номер 27, С. 15 - 57

Опубликована: Март 27, 2023

Titanium (Ti) and its alloys have been widely used as orthopedic implants, because of their favorable mechanical properties, corrosion resistance biocompatibility. Despite significant success in various clinical applications, the probability failure, degradation revision is undesirably high, especially for patients with low bone density, insufficient quantity or osteoporosis, which renders studies on surface modification Ti still active to further improve results. It discerned that physicochemical properties directly influence even control dynamic interaction subsequently determines rejection implants. Therefore, it crucial endow bulk materials specific high bioactivity can be performed by realize osseointegration. This article first reviews characteristics conventional techniques involving mechanical, physical chemical treatments based formation mechanism modified coatings. Such methods are able but surfaces static state cannot respond biological cascades from living cells tissues. Hence, beyond traditional design, responsive avenues then emerging. The stimuli sources functionalization originate environmental triggers physiological triggers. In short, this review surveys recent developments engineering materials, a emphasis advances functionality, provides perspectives improving biocompatibility

Язык: Английский

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Biomarker-driven molecular imaging probes in radiotherapy

Theranostics, Год журнала: 2024, Номер 14(10), С. 4127 - 4146

Опубликована: Янв. 1, 2024

Biomarker-driven molecular imaging has emerged as an integral part of cancer precision radiotherapy. The use probes, including nanoprobes, have been explored in radiotherapy to precisely and noninvasively monitor spatiotemporal distribution biomarkers, potentially revealing tumor-killing mechanisms therapy-induced adverse effects during radiation treatment.

Язык: Английский

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Highly Efficient Stable Luminescent Radical-Based X-ray Scintillator

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(49), С. 27095 - 27102

Опубликована: Ноя. 28, 2023

Stable luminescent radicals are open-shell emitters with unique doublet emission characteristics. This feature makes stable exhibit widespread application prospects in constructing optical, electrical, and magnetic materials. In this work, a radical-based X-ray scintillator of AuPP-1.0 was prepared, which exhibited high excited luminescence (XEL) efficiency as well excellent stability. A mechanism study showed that the heavy atom Au endowed it effective absorption X-rays, characteristics significantly increased its exciton utilization rate radioluminescence process. Moreover, has good processability to fabricate flexible screen for high-quality imaging, whose resolution can reach 20 LP mm-1. work demonstrates is beneficial improving radioluminescence, providing brand-new strategy construction high-performance scintillators.

Язык: Английский

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Water-dispersible X-ray scintillators enabling coating and blending with polymer materials for multiple applications

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Март 6, 2024

Abstract Developing X-ray scintillators that are water-dispersible, compatible with polymeric matrices, and processable to flexible substrates is an important challenge. Herein, Tb 3+ -doped Na 5 Lu 9 F 32 introduced as scintillating material steady-state light yields of 15,800 photons MeV −1 , which generated nanocrystals on halloysite nanotubes. The obtained product exhibits good water-dispersibility highly sensitive luminescence X-rays. It deposited onto a polyurethane foam afford composite dose-dependent radioluminescence. Moreover, the dispersed into polymer matrixes in aqueous solution prepare rigid or scintillator screen for imaging. As third example, it incorporated multilayer hydrogels information camouflage multilevel encryption. Encrypted can be recognized only by irradiation, while false read out under UV light. Altogether, we demonstrate water-dispersible promising processing radioluminescent, imaging, encrypting materials.

Язык: Английский

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Lanthanide-based nanoparticles for cancer phototherapy

Coordination Chemistry Reviews, Год журнала: 2024, Номер 508, С. 215773 - 215773

Опубликована: Март 14, 2024

Phototherapy, using light as a therapeutic modality, has been widely applied in treating various diseases, especially cancer. This approach is valued for its non-invasive nature and minimal risk of drug resistance. However, phototherapy faces challenges such the undesired delivery phototherapeutic agents, potential phototoxicity, limited penetration into tissues. Lanthanide-doped nanoparticles offer attractive opportunities to improve efficacy photodynamic therapy. These are distinguished by their unique optical properties, excellent photostability against blinking bleaching effects, large Stokes or anti-Stokes shifts, sharp emission peaks, long luminescence lifetimes. In addition, lanthanide-doped can be excited near-infrared (NIR) X-rays, enabling deep-tissue penetration. Beyond use photosensitizers, nanoparticle surfaces easily modified with targeting ligands, chemical drugs, functional molecules enhance effectiveness enable combination this review, we organize lanthanide-based tumor six main domains: therapy, photothermal X-ray-based light-controlled photoimmunotherapy, other innovative treatments that regulated light. We introduce basic principles characteristics lanthanide nanoparticles. Following this, summarize latest advances utilizing phototherapy, focusing on design principles, mechanisms action, cancer treatment. To conclude, address existing explore future within area research.

Язык: Английский

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Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Год журнала: 2024, Номер 36(27)

Опубликована: Март 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Язык: Английский

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High‐Confidentiality X‐Ray Imaging Encryption Using Prolonged Imperceptible Radioluminescence Memory Scintillators

Advanced Materials, Год журнала: 2023, Номер 35(52)

Опубликована: Ноя. 11, 2023

X-ray imaging plays an increasingly crucial role in clinical radiography, industrial inspection, and military applications. However, current technologies have difficulty protecting against information leakage caused by brute force attacks via trial-and-error. Here high-confidentiality encryption fabricating ultralong radioluminescence memory films composed of lanthanide-activated nanoscintillators (NaLuF4 : Gd3+ or Ce3+ ) with imperceptible purely-ultraviolet (UV) emission is reported. Mechanistic investigations unveil that attributed to the long-lived trapping thermalized charge carriers within Frenkel defect states subsequent slow release form radioluminescence. The encrypted can be securely stored film for more than 7 days optically decoded perovskite nanocrystal. Importantly, this strategy protect trial-and-error through perception lifetime change persistent It further demonstrated as-fabricated flexible enables achieving 3D curved objects a high spatial resolution 20 lp/mm excellent recyclability. This study provides valuable insights into fundamental understanding X-ray-to-UV conversion nanocrystal lattices opens up new avenue toward development high-confidential technologies.

Язык: Английский

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Hybrid Thermally Activated Nanocluster Fluorophores for X-ray Scintillators

ACS Energy Letters, Год журнала: 2023, Номер 8(12), С. 5088 - 5097

Опубликована: Ноя. 9, 2023

Thermally activated delayed fluorescence (TADF) X-ray scintillators have attracted increasing attention because of their theoretical ability to utilize 100% radiation-induced excitons. However, scintillation performance is severely hampered by typically low attenuation efficiencies or mechanochromic properties. Here, we demonstrate hybrid organic–inorganic TADF with remarkably high absorption cross sections based on non-mechanochromic Cu2X2 (X = Cl, Br, I) nanoclusters. The nanoclusters display radioluminescence light yields as 175 000 photons MeV–1, attributable self-absorption and spatially separated HOMO LUMO orbitals. Furthermore, properties, these can be formed into scintillating screens excellent radiation humidity stability via soft-pressing. fabricated a imaging efficiency, benefiting from spatial resolutions (∼30 lp mm–1). This work highlights the promise nanocluster-based in meeting demanding requirements cutting-edge imaging.

Язык: Английский

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Phototherapy: progress, challenges, and opportunities

Science China Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Язык: Английский

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Efficient metal free organic radical scintillators

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Сен. 18, 2024

Язык: Английский

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