Advanced NanoBiomed Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Lanthanide‐based
luminescence
nanothermometry
has
demonstrated
unprecedented
advantages
in
the
development
of
nanotheranostic
platforms
for
potential
medical
applications,
yet
despite
exponential
research
progress
and
great
enthusiasm
across
various
related
disciplines,
a
swift
bench‐to‐bedside
translation
seems
to
be
still
out
reach.
This
is
predominantly
fundamental
issues
at
preclinical
stage,
such
as
complex
nanomaterials
design,
incomplete
optimization,
fragmented
characterization,
insufficient
validation
nanothermometer
performance
physiological
environments.
The
main
impediments
currently
are
important
biophysicochemical
that
must
addressed
comprehensively,
first
foremost
available
vitro
systems,
before
going
on
vivo
investigations.
review
outlines
critical
perspective,
well
route
suggestions
underexplored
aspects
address
significantly
minimize
existing
translational
gap.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(16), С. 6373 - 6380
Опубликована: Апрель 11, 2024
To
the
deep
tissue
penetration
and
ultra-low
background,
developing
near-infrared
(NIR)
chemiluminescence
probes
for
human
health
environmental
safety
has
attracted
more
attention,
but
it
remains
a
huge
challenge.
Herein,
novel
NIR
(CL)
system
was
rationally
designed
developed,
utilizing
Cr
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
Abstract
Halide
perovskites
(HPs),
emerging
as
a
noteworthy
class
of
semiconductors,
hold
great
promise
for
an
array
optoelectronic
applications,
including
anti‐counterfeiting,
light‐emitting
diodes
(LEDs),
solar
cells
(SCs),
and
photodetectors,
primarily
due
to
their
large
absorption
cross
section,
high
fluorescence
efficiency,
tunable
emission
spectrum
within
the
visible
region,
tolerance
lattice
defects,
well
adaptability
solution‐based
fabrication
processes.
Unlike
luminescent
HPs
with
band‐edge
emission,
trivalent
rare‐earth
(RE)
ions
typically
emit
low‐energy
light
through
intra‐4f
optical
transitions,
characterized
by
narrow
spectra
long
lifetimes.
When
fused,
cooperative
interactions
between
REs
endow
resulting
binary
composites
not
only
properties
inherited
from
parent
materials
but
also
introduce
new
attributes
unattainable
either
component
alone.
This
review
begins
fundamental
characteristics
REs,
followed
particular
focus
on
impact
electronic
structures
associated
energy
transfer
The
advanced
synthesis
methods
utilized
prepare
HPs,
RE‐doped
compounds,
are
overviewed.
Furthermore,
potential
applications
summarized
across
diverse
domains,
high‐fidelity
anticounterfeiting,
bioimaging,
LEDs,
photovoltaics,
photodetection,
photocatalysis,
conclude
remaining
challenges
future
research
prospects.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Lanthanides
are
particularly
effective
in
their
clinical
applications
magnetic
resonance
imaging
and
diagnostic
assays.
They
have
open-shell
4f
electrons
that
give
rise
to
characteristic
narrow,
line-like
emission
which
is
unique
from
other
fluorescent
probes
biological
systems.
Lanthanide
luminescence
signal
offers
selection
of
detection
pathways
based
on
the
choice
ion
visible
near-infrared
with
long
lifetimes
lend
themselves
time-resolved
measurements
for
optical
multiplexing
schemes
novel
bioimaging
applications.
The
delivery
lanthanide
agents
cells
allows
localized
bioresponsive
activity
therapies.
Detection
region
spectrum
coupled
technological
advances
microscopies
opens
new
avenues
deep-tissue
surgical
interventions.
This
review
focuses
different
ways
can
be
exploited
nucleic
acid
enzyme
detection,
anion
recognition,
cellular
imaging,
tissue
photoinduced
therapeutic
We
focused
hierarchy
designs
include
luminescent
lanthanides
as
biology
considering
coordination
complexes,
multimetallic
systems
metal-organic
frameworks
nanoparticles
highlighting
strategies
downshifting,
upconversion
revealing
some
opportunities
challenges
offer
potential
further
development
field.
Nano-Micro Letters,
Год журнала:
2023,
Номер
16(1)
Опубликована: Дек. 4, 2023
Ultrasmall
gold
nanoparticles
(AuNPs)
typically
includes
atomically
precise
nanoclusters
(AuNCs)
and
AuNPs
with
a
core
size
below
3
nm.
Serving
as
bridge
between
small
molecules
traditional
inorganic
nanoparticles,
the
ultrasmall
show
unique
advantages
of
both
(e.g.,
rapid
distribution,
renal
clearance,
low
non-specific
organ
accumulation)
long
blood
circulation
enhanced
permeability
retention
effect).
The
emergence
creates
significant
opportunities
to
address
many
challenges
in
health
field
including
disease
diagnosis,
monitoring
treatment.
Since
nano–bio
interaction
dictates
overall
biological
applications
AuNPs,
this
review
elucidates
recent
advances
interactions
imaging
AuNPs.
We
begin
introduction
factors
that
influence
cellular
then
discuss
interactions,
especially
focus
on
liver
kidneys.
further
present
tumor
In
addition,
performance
is
summarized
discussed.
Finally,
we
summarize
provide
some
perspective
future
research
direction
aiming
accelerate
their
clinical
translation.
Abstract
In
the
progression
of
X‐ray‐based
radiotherapy
for
treatment
cancer,
incorporation
nanoparticles
(NPs)
has
a
transformative
impact.
This
study
investigates
potential
NPs,
particularly
those
comprised
high
atomic
number
elements,
as
radiosensitizers.
aims
to
optimize
localized
radiation
doses
within
tumors,
thereby
maximizing
therapeutic
efficacy
while
preserving
surrounding
tissues.
The
multifaceted
applications
NPs
in
encompass
collaborative
interactions
with
chemotherapeutic,
immunotherapeutic,
and
targeted
pharmaceuticals,
along
contributions
photodynamic/photothermal
therapy,
imaging
enhancement,
integration
artificial
intelligence
technology.
Despite
promising
preclinical
outcomes,
paper
acknowledges
challenges
clinical
translation
these
findings.
conclusion
maintains
an
optimistic
stance,
emphasizing
ongoing
trials
technological
advancements
that
bolster
personalized
approaches.
advocates
continuous
research
validation,
envisioning
revolutionary
paradigm
cancer
ultimately
enhancing
patient
outcomes.
Biomaterials Science,
Год журнала:
2024,
Номер
12(18), С. 4650 - 4663
Опубликована: Янв. 1, 2024
Upconversion
nanoparticles
(UCNPs)
are
a
class
of
nanomaterials
composed
lanthanide
ions
with
great
potential
for
paraclinical
applications,
especially
in
laboratory
and
imaging
sciences.
UCNPs
have
tunable
optical
properties
the
ability
to
convert
long-wavelength
(low
energy)
excitation
light
into
short-wavelength
(high
emission
ultraviolet
(UV)-visible
near-infrared
(NIR)
spectral
regions.
The
core-shell
structure
can
be
customized
through
chemical
synthesis
meet
needs
different
applications.
surface
also
tailored
by
conjugating
small
molecules
and/or
targeting
ligands
achieve
high
specificity
selectivity,
which
indispensable
elements
biomedical
Specifically,
coatings
enhance
water
dispersion,
biocompatibility,
efficiency
UCNPs,
thereby
optimizing
their
functionality
boosting
performance.
In
this
context,
multimodal
provide
more
accurate
Advanced Materials,
Год журнала:
2023,
Номер
36(5)
Опубликована: Авг. 29, 2023
Lysosomes
are
critical
in
modulating
the
progression
and
metastasis
for
various
cancers.
There
is
currently
an
unmet
need
lysosomal
alkalizers
that
can
selectively
safely
alter
pH
inhibit
function
of
cancer
lysosomes.
Here
effective,
selective,
safe
alkalizer
reported
autophagy
suppress
tumors
mice.
The
consists
iron
oxide
core
generates
hydroxyl
radicals
(•OH)
presence
excessive
H
