Biomaterials, Год журнала: 2024, Номер 316, С. 123020 - 123020
Опубликована: Дек. 15, 2024
Язык: Английский
Chemical Reviews, Год журнала: 2024, Номер 124(13), С. 8307 - 8472
Опубликована: Июнь 26, 2024
Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.
Язык: Английский
Процитировано
49
Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216122 - 216122
Опубликована: Авг. 6, 2024
Язык: Английский
Процитировано
22
Small Methods, Год журнала: 2024, Номер unknown
Опубликована: Март 12, 2024
Abstract Intravital fluorescence imaging in the second near‐infrared window (NIR‐II, 900–1700 nm) has emerged as a promising method for non‐invasive diagnostics complex biological systems due to its advantages of less background interference, high tissue penetration depth, contrast, and sensitivity. However, traditional NIR‐II imaging, which is characterized by “always on” or “turn mode, lacks ability quantitative detection, leading low reproducibility reliability during bio‐detection. In ratiometric can realize reliable analysis detection vivo providing reference signals correction, generating new opportunities prospects bioimaging biosensing. this review, current design strategies sensing mechanisms probes biosensing applications are systematically summarized. Further, challenges, future perspectives designing also discussed. It hoped that review provide effective guidance promote adoption vivo.
Язык: Английский
Процитировано
21
Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216551 - 216551
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
2
Analytical Chemistry, Год журнала: 2024, Номер 96(18), С. 7138 - 7144
Опубликована: Апрель 27, 2024
Superoxide anion (O2·–) and peroxynitrite (ONOO–), two important oxidants under oxidative stress, coexist in complex cell organism systems, playing crucial roles various physiological pathological processes, particularly neurodegenerative diseases. Despite the absence of robust molecular tools capable simultaneously visualizing O2·– ONOO– biosystems, relationship between these species remains understudied. Herein, we present sequentially activated fluorescent probe, DHX-SP, which exhibits exceptional selectivity sensitivity toward ONOO–. This probe enables precise imaging living PC12 cells stress conditions using distinct fluorescence signal combinations. Furthermore, DHX-SP has ability to visualize changes levels during ferroptosis Parkinson's disease model. These findings establish a connection crosstalk phosphorus group stress.
Язык: Английский
Процитировано
7
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Янв. 5, 2025
Abstract Lateral flow assays (LFAs) are widely applicable in clinical point‐of‐care testing (POCT) due to their unique advantages such as simplicity, rapidity, and cost‐effectiveness. However, sensitivity is often constrained by the background autofluorescence of biological sample, self‐matrix, or readout technique, thereby leading overlooking trace amounts biomarkers present early disease. In recent years, various nanomaterials‐based methods have been developed address this issue, including time‐gated wavelength‐differentiated strategy external modulated for separation minimize interference from samples. This review provides a comprehensive overview low‐background luminescent nanoparticles (LBLNPs)‐enhanced LFA systems, focusing on analyzing underlying mechanism these nanomaterials improving accuracy LFAs platform diagnosis. Representative examples selected demonstrate potential detecting disease‐associated samples blood, urine, saliva et al. Finally, unresolved challenges future development prospects briefly discussed.
Язык: Английский
Процитировано
1
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(35)
Опубликована: Июнь 8, 2024
Abstract The abnormal fluctuation of temperature in vivo usually reflects the progression inflammatory diseases. Noninvasive, real‐time, and accurate monitoring imaging variation is advantageous for guiding early diagnosis treatment disease, but it remains difficult to achieve. Herein, we developed a temperature‐activated near‐infrared‐II fluorescence (NIR‐II FL) surface‐enhanced Raman scattering (SERS) nanoprobe long‐term changes rat arthritis timely assessment status osteoarthritis. thermosensitive polymer bearing NIR‐II FL dye was grafted onto surface nanoporous core‐satellite gold nanostructures form nanoprobe, wherein contains reference signals that are independent change. ratiometric 1150/ 1550 S 1528 /S 2226 values exhibited reversible conversion with changes. accurately distinguishes variations inflamed joint versus normal by SERS imaging, allowing an inflammation. Meanwhile, can continuously monitor fluctuations over extended period during onset tested change trend could be used as indicator inflammation real‐time evaluation therapeutic effects.
Язык: Английский
Процитировано
4
ACS Nano, Год журнала: 2024, Номер 18(51), С. 34912 - 34923
Опубликована: Дек. 11, 2024
Capsules were widely used in clinical settings for the oral delivery of various drugs, although it remains challenging to trace real-time drug release behavior and adjust dosages based on therapeutic effect. To address these issues, we developed theranostic capsules that loaded two kinds fluorescence nanoparticles, H2O2-responsive Janus Ag/Ag2S nanoparticles (Ag/Ag2S JNPs) downconversion (DCNPs), dexamethasone (Dex) drug. The JNPs exhibit a highly sensitive (FL) signal at 1250 nm response H2O2, while FL from DCNPs 1550 stable under physiological conditions. ratio signals formed ratiometric signal, which shows correlation with H2O2 concentration detection limit 1.7 μM. Moreover, can be precisely delivered into intestine, where they simultaneously. H2O2-triggered images diagnose inflammation indicate its location. Meanwhile, encapsulated Dex is released disease region, imaging allowing tracking efficacy providing guidance ongoing treatment. capsule system provides an approach quantitative biomarkers further localized therapeutics, thereby avoiding overdose reducing side effects.
Язык: Английский
Процитировано
3
Theranostics, Год журнала: 2025, Номер 15(10), С. 4481 - 4494
Опубликована: Март 19, 2025
Tumor-infiltrating CD8+ T cells and programmed death-1 (PD1) levels are critical indicators for tumor immunophenotyping therapeutic decision-making. Noninvasive optical imaging in the second near infrared window (NIR-II) is particularly well-suited investigating biological processes within tumors live mammals, thanks to its deep-tissue penetration superior spatiotemporal resolution. However, vivo NIR-II has primarily been restricted a single probe at time. Methods: Herein, we developed two-plex molecular method utilizing non-overlapping fluorescence emission of indocyanine green (ICG) NIR-IIa (1000-1200 nm) PbS/CdS core-shell quantum dots (QDs) NIR-IIb (1500-1700 nm). By integrating PD1 aptamer-labeled ICG (ICG-Apt-PD1, targeting PD1) CD8 QDs (QDs@Apt-CD8, cells), our enabled simultaneous noninvasive monitoring number tumors. Results: QDs@Apt-CD8 demonstrated excellent ability infiltrating cells, owing strong luminescence high selectivity specificity. This allowed dynamic We observed heterogeneous bio-distributions across different types revealed immunophenotypes. Moreover, findings indicated that low predicted better anti-tumor effect. Conclusions: Such would complement ex biopsy-based diagnostic techniques, it could contribute developing an immune-scoring algorithm offer more precise prediction immunotherapeutic response.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 17, 2025
Abstract The efficacy of radiotherapy (RT) is often limited by insufficient tumor selectivity and suboptimal therapeutic responses. To overcome these problems, a new kind selenium‐doped Ag/Ag 2 S Janus nanoparticles (Ag/Ag Se x y JNPs) presented as radio‐responsive molecular probes for precise imaging enhanced radiosensitization. By adjusting the selenium precursor input, heterojunction with tunable doping ratios are synthesized, optimizing X‐ray absorption energy storage properties. Upon irradiation, JNPs interact overexpressed hydrogen peroxide (H O ) in cells, generating highly toxic hydroxyl radicals (·OH), which effectively induce cell apoptosis. Additionally, Selenium incorporation improves electron–hole pair separation efficiency enhances photocurrent response, promoting increased electron transfer ·OH generation, thus amplifying reactive oxygen species (ROS) production enhancing Furthermore, fluorescence “OFF‐ON” mechanism, triggered H ‐induced etching silver allows real‐time monitoring levels via second near‐infrared window (NIR‐II) (FL) “Turn On”, delineates boundaries RT reduce side effects to normal tissue. This dual‐functional platform not only enables tracking but also outcomes, offering promising approach precision cancer treatment.
Язык: Английский
Процитировано
0