Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Июль 12, 2023

Abstract Apoptosis, a form of programmed cell death, is essential for growth and tissue homeostasis. Apoptotic bodies (ApoBDs) are extracellular vesicles (EVs) released by dying cells in the last stage apoptosis were previously regarded as debris dead cells. Recent studies unraveled that ApoBDs not but bioactive treasure left behind with an important role intercellular communications related to human health various diseases. Defective clearance infected-cells-derived possible etiology some Therefore, it necessary explore function mechanism action different physiological pathological conditions. advances have elucidated immunomodulatory, virus removal, vascular protection, regenerative, disease diagnostic potential ApoBDs. Moreover, can be used drug carriers enhancing stability, cellular uptake, targeted therapy efficacy. These reports from literature indicate hold promising diagnosis, prognosis, treatment diseases, including cancer, systemic inflammatory cardiovascular regeneration. This review summarizes recent ApoBDs-related research discusses diseases well challenges prospects ApoBDs-based therapeutic applications. Graphical

Язык: Английский

---

Immunogenicity of Extracellular Vesicles

Advanced Materials, Год журнала: 2024, Номер 36(33)

Опубликована: Июнь 27, 2024

Extracellular vesicles (EVs) are promising next-generation therapeutics and drug delivery systems due to demonstrated safety efficacy in preclinical models early-stage clinical trials. There is an urgent need address the immunogenicity of EVs (beyond apparent lack immunotoxicity) advance development. To date, few studies have assessed unintended immunological recognition EVs. An in-depth understanding EV-induced clearance necessary develop effective therapeutic strategies, including approaches mitigate when undesired. This article summarizes various factors involved potential strategies reduce for improved benefit.

Язык: Английский

---

Exploring Therapeutic Potential of Catalase: Strategies in Disease Prevention and Management

Biomolecules, Год журнала: 2024, Номер 14(6), С. 697 - 697

Опубликована: Июнь 14, 2024

The antioxidant defense mechanisms play a critical role in mitigating the deleterious effects of reactive oxygen species (ROS). Catalase stands out as paramount enzymatic antioxidant. It efficiently catalyzes decomposition hydrogen peroxide (H

Язык: Английский

---

Unveiling clinical applications of bacterial extracellular vesicles as natural nanomaterials in disease diagnosis and therapeutics

Acta Biomaterialia, Год журнала: 2024, Номер 180, С. 18 - 45

Опубликована: Апрель 17, 2024

Bacterial extracellular vesicles (BEVs) are naturally occurring bioactive membrane-bound nanoparticles released by both gram-negative and gram-positive bacterial species, exhibiting a multifaceted role in mediating host-microbe interactions across various physiological conditions. Increasing evidence supports BEVs as essential mediators of cell-to-cell communicaiton, influencing pathogenicity, disease mechanisms, modulating the host immune response. However, extent to which these BEV-mediated actions can be leveraged predict onset, guide treatment strategies, determine clinical outcomes remains uncertain, particularly terms their translation potentials. This review briefly describes BEV biogenesis internalisation recipient cells summarises methods for isolation characterization, understanding composition cargo. Further, it discusses potential biofluid-associated biomarkers diseases, spanning cancer non-cancerous Following this, we outline ongoing human trials using vaccine development. In addition diagnostics, this explores emerging research natural or engineered smart nanomaterials applications anti-cancer therapy bone regeneration. discussion extends key factors unlocking BEVs, such standardization characterisation, well other hurdles translating findings setting. We propose that addressing through collaborative efforts well-designed holds fully harnessing BEVs. As field advances, suggests BEV-based nanomedicine has revolutionize management, paving way innovative diagnosis, therapeutics, personalized medicine approaches. STATEMENT OF SIGNIFICANCE: Extracellular (EVs) from bacteria serve multifunctional biomaterials fields biomedicine, bioengineering, biomaterials. majority current studies focus on host-derived EVs, leaving gap comprehensive bacteria-derived EVs (BEVs). Although offer an attractive option drug delivery systems, unique nanostructure easy-to-modify functions make them method diagnosis Our work among pioneering investigating nanobiomaterials plays crucial development diseases therapeutic interventions.

Язык: Английский

---

Engineering therapeutical extracellular vesicles for clinical translation

Trends in biotechnology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

---