Chemistry - An Asian Journal,
Год журнала:
2020,
Номер
15(7), С. 947 - 957
Опубликована: Фев. 7, 2020
Abstract
Organic
room
temperature
phosphorescence
(RTP)
materials
have
drawn
increasing
attention
due
to
their
unique
features,
especially
the
long
emission
lifetime
for
applications
in
biomedicine.
In
this
review,
we
provide
an
overview
of
recent
developments
organic
RTP
applied
biomedicine
field.
First,
introduce
basic
mechanism
and
subsequently
present
various
strategies
modulating
efficiency
phosphorescence.
Next,
summarize
progress
biological
applications,
including
bioimaging,
anti‐cancer
antibacterial
therapies.
Finally,
outlook
with
regard
challenges
future
perspectives
Nano TransMed,
Год журнала:
2024,
Номер
3, С. 100032 - 100032
Опубликована: Янв. 29, 2024
Nanozymes
exhibit
immense
potential
and
promising
prospects
in
the
realm
of
diagnostic
imaging
tumor
therapy,
owing
to
their
inherent
physicochemical
properties
enzymatic
activities.
With
further
development
application
nanotechnology,
nanozymes
are
expected
become
an
important
tool
field
medicine,
providing
new
solutions
for
disease
diagnosis
treatment.
This
review
provides
overview
recent
studies
over
past
five
years
on
capable
responding
microenvironment
(TME)
multimodal
imaging,
with
a
focus
hypoxia,
acid
pH,
excess
GSH
ROS.
In
addition,
we
present
current
status
several
common
related
contrast
agents,
such
as
MRI/CT,
MRI/PET,
MRI/SPECT,
PET/CT.
Moreover,
some
thoughts
challenges,
future
development,
clinical
translation
microenvironment-responsive
shared.
aims
provide
up-to-date
theranostic
nanomedicine
reference
those
who
fields,
promote
progress
this
interdisciplinary
subject,
accelerate
translation.
Abstract
The
growth
state
of
tumor
cells
is
strictly
affected
by
the
specific
abnormal
redox
status
microenvironment
(TME).
Moreover,
reactions
at
biological
level
are
also
central
and
fundamental
to
essential
energy
metabolism
in
tumors.
Accordingly,
anti‐tumor
nanodrugs
targeting
disruption
this
homeostasis
have
become
one
hot
spots
field
research
due
effectiveness
TME
modulation
efficiency
mediated
interference.
This
review
discusses
latest
results
therapy,
which
regulate
levels
oxidants
or
reductants
through
a
variety
therapeutic
strategies,
ultimately
breaking
original
“stable”
promoting
cell
death.
With
gradual
deepening
study
on
vigorous
development
nanomaterials,
it
expected
that
more
nano
drugs
based
regulation
will
be
designed
even
applied
clinically.
Nano-Micro Letters,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 24, 2025
Abstract
Sonodynamic
therapy
(SDT)
as
an
emerging
modality
for
malignant
tumors
mainly
involves
in
sonosensitizers
and
low-intensity
ultrasound
(US),
which
can
safely
penetrate
the
tissue
without
significant
attenuation.
SDT
not
only
has
advantages
including
high
precision,
non-invasiveness,
minimal
side
effects,
but
also
overcomes
limitation
of
low
penetration
light
to
deep
tumors.
The
cytotoxic
reactive
oxygen
species
be
produced
by
utilization
combined
with
US
kill
tumor
cells.
However,
underlying
mechanism
been
elucidated,
its
unsatisfactory
efficiency
retards
further
clinical
application.
Herein,
we
shed
on
main
mechanisms
types
sonosensitizers,
organic
inorganic
sonosensitizers.
Due
development
nanotechnology,
many
novel
nanoplatforms
are
utilized
this
arisen
field
solve
barriers
enable
continuous
innovation.
This
review
highlights
potential
nanosonosensitizers
focus
enhanced
based
monotherapy
or
synergistic
that
difficult
reach
traditional
treatment,
especially
orthotopic
cancers.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 26, 2025
Abstract
Photodynamic
therapy
(PDT)
using
traditional
type
II
photosensitizers
(PSs)
has
been
limited
in
hypoxic
tumors
due
to
excessive
oxygen
consumption.
The
conversion
from
into
a
less
oxygen‐dependent
I
PDT
pathway
shown
the
potential
combat
tumors.
Herein,
design
of
heterodimeric
PS,
NBSSe
,
by
conjugating
widely
used
PS
NBS
and
NBSe
via
molecular
dimerization,
achieving
aggregation‐regulated
efficient
photodynamic
for
first
time
is
reported.
Electrochemistry
characterizations
theoretical
calculations
elucidate
that
tends
form
S
+·
/Se
−·
radical
pair
intramolecular
electron
transfer
co‐excited
*
aggregate,
realizing
7.25‐fold
O
2
generation
compared
80%
suppression
1
.
enhanced
enables
excellent
anti‐hypoxia
efficiency
inhibition
pulmonary
metastasis.
Additionally,
incorporation
electron‐rich
bovine
serum
albumin
accelerates
recycling
cationic
further
boosting
photostability
generation.
resultant
BSA@NBSSe
nanoparticles
demonstrate
successful
tumor‐targeting
capability.
This
work
provides
an
appealing
avenue
convert
ROS
cancer
phototherapy
hypoxia.
Chemistry - An Asian Journal,
Год журнала:
2020,
Номер
15(7), С. 947 - 957
Опубликована: Фев. 7, 2020
Abstract
Organic
room
temperature
phosphorescence
(RTP)
materials
have
drawn
increasing
attention
due
to
their
unique
features,
especially
the
long
emission
lifetime
for
applications
in
biomedicine.
In
this
review,
we
provide
an
overview
of
recent
developments
organic
RTP
applied
biomedicine
field.
First,
introduce
basic
mechanism
and
subsequently
present
various
strategies
modulating
efficiency
phosphorescence.
Next,
summarize
progress
biological
applications,
including
bioimaging,
anti‐cancer
antibacterial
therapies.
Finally,
outlook
with
regard
challenges
future
perspectives
