Sensors and Actuators B Chemical, Год журнала: 2024, Номер 420, С. 136506 - 136506
Опубликована: Авг. 23, 2024
Язык: Английский
Analytical Chemistry, Год журнала: 2024, Номер 96(33), С. 13663 - 13671
Опубликована: Авг. 10, 2024
Rapid and accurate detection of human epidermal growth factor receptor 2 (HER2) is crucial for the early diagnosis prognosis breast cancer. In this study, we reported an iron-manganese ion N-doped carbon single-atom catalyst (FeMn-NC
Язык: Английский
Процитировано
51
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 14, 2024
Abstract Electrochemical (EC) analysis has emerged as a high‐sensitivity, reliable, cost‐effective, and rapidly evolving technique that garnered significant attention across diverse domains. Furthermore, EC‐based techniques hold great potential for miniaturization integration. The integration of EC with mode/signal (such light, magnetic, thermal signals, etc.) provides unique opportunities biosensors to acquire more information through single sensing platform. By coupling multiple signals or processing them logically, the detection accuracy can be further improved, probability false positives negatives minimized. In this review, thorough multi‐ sensors in field is conducted, along their various (e.g., fluorescence, photothermal, colorimetry, microfluidic, etc.). aim delve into latest advances, applications, well challenges multi‐mode/signal biosensors, where utilization modalities helps enhance accuracy, sensitivity, selectivity. This review new insight synergistic effects integrating other techniques, aiming shed light on near‐future developments EC‐integrated biosensors.
Язык: Английский
Процитировано
22
Small, Год журнала: 2023, Номер 20(22)
Опубликована: Дек. 28, 2023
Abstract Electrochemiluminescence (ECL) as an analytical technology with a perfect combination of electrochemistry and spectroscopy has received considerable attention in bioanalysis due to its high sensitivity broad dynamic range. Given the selectivity bio‐recognition elements ECL analysis technique, biosensors are powerful platforms for sensitive detection biomarkers, achieving accurate prognosis diagnosis diseases. MicroRNAs (miRNAs) crucial biomarkers involved variety physiological pathological processes, whose aberrant expression is often related serious diseases, especially cancers. can fulfill highly selective requirements miRNA detection, prompting this review. The mechanisms initially introduced subsequently categorize terms quenching agents. Furthermore, work highlights signal amplification strategies enhancing improve finally concludes by looking at challenges opportunities detection.
Язык: Английский
Процитировано
24
Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 149911 - 149911
Опубликована: Фев. 21, 2024
Язык: Английский
Процитировано
10
Biosensors and Bioelectronics, Год журнала: 2024, Номер 252, С. 116149 - 116149
Опубликована: Фев. 20, 2024
Язык: Английский
Процитировано
9
Food Chemistry, Год журнала: 2024, Номер 444, С. 138594 - 138594
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
6
Journal of Electroanalytical Chemistry, Год журнала: 2024, Номер 960, С. 118194 - 118194
Опубликована: Март 15, 2024
Язык: Английский
Процитировано
6
Analytical Chemistry, Год журнала: 2024, Номер 96(21), С. 8682 - 8688
Опубликована: Май 17, 2024
Programming ultrasensitive and stimuli-responsive DNAzyme-based probes holds great potential for on-demand biomarker detection. Here, an optically triggered DNAzyme platform was reported activation-sensitive electrochemiluminescence (ECL) c-myc mRNA analysis. In this design, the sensing recognition function of split (SDz) probe silent by engineering a blocking sequence containing photocleavable linker (PC-linker) group at defined site that could be indirectly cleaved 302 nm ultraviolet (UV) light. When SDz were assembled on Au nanoparticles potassium (K) element doped graphitic carbon nitride nanosheet (K-doped g-C3N4) covered electrode, UV light activation induces configurational switching consequently formation active with help target mRNA, allowing cleavage substrate strand magnesium ions (Mg2+). Thus, release ferrocene (Fc)-labeled 2 contributed to extreme ECL signal recovery. meantime, released combined another inactive motif form repeat cyclic reaction, resulting in amplification. Furthermore, according responses toward two other designed nPC-SDz m-SDz probes, we demonstrated controlled mediated photoactivation biosensor "on demand" effectively constrained interest. Moreover, false positive signals also avoided due such design Therefore, study provided simple methodology may broadly applicable investigating mRNA-associated physiological events difficult access using traditional probes.
Язык: Английский
Процитировано
5
Analytical Chemistry, Год журнала: 2024, Номер 96(37), С. 14918 - 14925
Опубликована: Авг. 28, 2024
Convenient and accurate quantification of disease-relevant multitargets is essential for community disease screening. However, in the field photoelectrochemical (PEC) sensors multisubstance detection, research on continuous detection multiple targets using a polarity-switching mode scarce. In this study, multiplexed PEC bioassay was developed based target-triggered "anodic–cathodic–anodic" multiple-polarity-switchable mode. Employing miRNA-21 miRNA-141 as model analytes, photosensitive material combinations Cu2O/gold nanoparticles (AuNPs)/TiO2 CdS/AuNPs/TiO2 were successively formed through specific binding different whisker branches Whisker-DNA to Cu2O–H1 CdS-tripod DNA ring, respectively. This process reverses photocurrent polarity from anodic cathodic then back upon detecting targets, resulting high-sensitivity various biological with reduced interference. To enhance device's utility affordability screening, integrating capacitor multimeter-smartphone connection simplifies assembly reduces costs. developing sensor, device demonstrated linear ranges 0.01 fM 10 nM. Detection limits established at 3.2 4.3 aM, The innovative offers adaptability other multitarget detections by simply modifying structure combination materials.
Язык: Английский
Процитировано
5
Analytica Chimica Acta, Год журнала: 2025, Номер 1341, С. 343685 - 343685
Опубликована: Янв. 18, 2025
Язык: Английский
Процитировано
0