Electrophoresis,
Год журнала:
2023,
Номер
45(13-14), С. 1233 - 1242
Опубликована: Дек. 31, 2023
Abstract
The
efficient
and
precise
extraction
of
target
particles
is
a
crucial
prerequisite
for
achieving
accurate
detection
analysis
in
microfluidic
cell
analysis.
In
this
study,
symmetrical
contraction–expansion
microchannel
with
sheath
flow
was
designed,
aiming
to
extract
larger
from
different
sizes
within
the
channel.
This
paper
conducted
numerical
simulations
investigate
three‐dimensional
migration
mechanisms
performed
experimental
studies
examine
separation
performance
under
varying
rate
ratios
numbers
structures.
results
indicate
that
at
moderate
sample
rates
higher
ratios,
microchannels
fewer
structures
are
likely
achieve
better
extracting
compared
greater
number
these
Our
work
advances
application
viscoelastic
particle
separation.
device
easy
set
up
parallel
significantly
enhances
throughput,
providing
an
solution
future
applications.
This
review
highlights
recent
technological
advances
for
progress
in
particle
manipulation
under
X-force
fields,
and
forecasts
the
trajectory
of
future
developments.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 30, 2023
Sweat
is
a
noninvasive
metabolite
that
can
provide
clinically
meaningful
information
about
physical
conditions
without
harming
the
body.
Glucose,
vital
component
in
sweat,
closely
related
to
blood
glucose
levels,
and
changes
its
concentration
reflect
health
status
of
diabetics.
We
introduce
self-adhesive,
wearable
microfluidic
chip
with
erasable
liquid
metal
plasmonic
hotspots
for
precise
detection
sweat.
The
made
from
modified
polydimethylsiloxane
(PDMS)
enhanced
stickiness,
enabling
conformal
contact
skin,
collect,
deliver,
store
are
located
inside
channel,
generated
by
synthesizing
silver
nanostructures
on
metal,
be
removed
alkaline
solution.
It
indicates
reproducible
nature
hotspots.
method
based
surface-enhanced
Raman
spectroscopy
(SERS),
which
allows
accurate
concentration.
To
enhance
sensitive
glucose,
SERS
substrate
4-mercaptophenylboronic
acid
achieve
limit
1
ng/L
much
lower
than
physiological
(7.2–25.2
μg/L).
developed
soft,
stretchable,
nontoxic,
bringing
new
possibilities
sweat-sensing
devices.
Fluid–structure
interaction
(FSI)
is
a
nonlinear
multiphysics
phenomenon
that
describes
the
interactions
between
incompressible
fluid
flows
and
immersed
structures,
making
it
invaluable
to
biomedical
research.
In
this
work,
common
FSI
methodologies
in
research
were
systematically
summarized
classified
into
three
groups
based
on
interfaces:
fluid–channel
interfaces,
fluid–particle
multi-interface
interactions.
A
discussion
of
role
numerical
methods
was
also
made,
outlining
its
indispensable
advantage
handling
complex
geometries,
boundary
conditions,
thus
interfaces.
The
applications
these
are
discussed
terms
blood
vessel-related
applications,
drug-delivering
micropumps,
particle
dynamics/cell
sorting,
deformation
rapture.
development
progress,
current
advances,
prospects
FSI's
future
application
illustrated.
It
concluded
with
advances
computation
technologies,
rapidly
developing
can
achieve
state-of-the-art
level
details,
helping
improve
our
understanding
various
biomedical-related
problems
use
techniques
likely
continue
grow.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 8, 2024
The
ability
to
manipulate
and
focus
particles
within
microscale
fluidic
environments
is
crucial
advancing
biological,
chemical,
medical
research.
Precise
high-throughput
particle
focusing
an
essential
prerequisite
for
various
applications,
including
cell
counting,
biomolecular
detection,
sample
sorting,
enhancement
of
biosensor
functionalities.
Active
sheath-assisted
techniques
offer
accuracy
but
necessitate
the
introduction
external
energy
fields
or
additional
sheath
flows.
In
contrast,
passive
methods
exploit
inherent
fluid
dynamics
in
achieving
without
actuation.
This
review
analyzes
latest
developments
strategies
sheathless
inertial
focusing,
emphasizing
elasto-inertial
microfluidic
from
channel
structure
classifications.
These
methodologies
will
serve
as
pivotal
benchmarks
broader
application
technologies
biological
manipulation.
Then,
prospects
future
development
are
also
predicted.
paper
assist
understanding
design
devices.
Lab on a Chip,
Год журнала:
2024,
Номер
24(9), С. 2506 - 2517
Опубликована: Янв. 1, 2024
We
develop
a
microfluidic
device
with
closed
right-angle
bipolar
electrodes
to
realize
dielectrophoretic
characterization
and
selection
of
non-spherical
flagellate
algae.
Micromachines,
Год журнала:
2024,
Номер
15(7), С. 893 - 893
Опубликована: Июль 8, 2024
With
the
rapid
development
of
biotechnology,
importance
microfluidic
bioseparation
and
bioassay
in
biomedicine,
clinical
diagnosis,
other
fields
has
become
increasingly
prominent.
Microfluidic
technology,
with
its
significant
advantages
high
throughput,
automated
operation,
low
sample
consumption,
brought
new
breakthroughs
field
biological
separation
bioassay.
In
this
paper,
latest
research
progress
technology
is
reviewed.
Then,
we
focus
on
methods
including
active
separation,
passive
hybrid
separation.
At
same
time,
results
our
group
particle
are
introduced.
Finally,
some
application
examples
or
for
after
listed,
current
challenges
future
prospects
discussed.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(35), С. 14306 - 14314
Опубликована: Авг. 21, 2024
Serpentine
channels
coupling
inertial
and
secondary
flows
enable
effective
particle
focusing
separation,
showing
great
potential
in
clinical
diagnostics
drug
screening.
However,
the
nonsteady
serpentine
channel
make
evolution
of
migration
unclear,
hindering
development
application
channel.
Herein,
to
refine
mechanism,
we
established
a
model
with
varying
curvature
ratios
study
effect
flow
on
This
method
used
direct
numerical
simulation
(DNS)
calculate
lift,
mapped
lift
cross
sections
channel,
deciphered
by
using
Lagrangian
tracking
(LPT)
method.
The
microparticles
is
experimentally
investigated
validate
model.
results
indicate
that
follows
two-stage
migration.
An
increase
accelerates
second
stage
process
while
slowing
first
process.
Subsequently,
effects
different
parameters,
including
Reynolds
number,
aspect
ratio,
blockage
equilibrium
positions
particles,
providing
guidelines
for
high-resolution
separation
particles.
Taking
resistance
into
account,
dimensionless
makes
arbitrary-sized
particles
possible.
work
reveals
mechanism
channels,
paving
way
ACS Sensors,
Год журнала:
2024,
Номер
9(8), С. 3958 - 3966
Опубликована: Июль 29, 2024
Glaucoma
is
the
world's
second-leading
irreversible
eye
disease
causing
blindness.
Although
pathogenesis
of
glaucoma
not
particularly
well
understood,
high
intraocular
pressure
(IOP)
widely
recognized
as
a
significant
risk
factor.
In
clinical
practice,
various
devices
have
been
used
to
measure
IOP,
but
most
them
cannot
provide
continuous
measurements
for
long
time.
To
meet
needs
patients
who
experience
frequent
fluctuations
in
IOP
and
require
constant
monitoring,
we
fabricated
an
implantable
piezoresistive
sensor
based
on
microfluidic
technology.
The
has
sensitivity
0.00257
Ω/mbar
demonstrates
excellent
linearity,
stability,
repeatability.
According
calibration
data,
average
measurement
error
±0.5
mbar.
We
implanted
it
into
vitreous
rabbit
successfully
detected
its
fluctuations.
simple
design,
easy
fabricate,
can
be
long-term
measurements.
It
presents
new
approach
microfluidic-based
sensors
offers
novel
method
daily
care
with
glaucoma.
