m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis DOI Creative Commons
Ming Gao,

Zijuan Qi,

Wenya Feng

и другие.

Journal of Biological Chemistry, Год журнала: 2022, Номер 298(2), С. 101563 - 101563

Опубликована: Янв. 6, 2022

The cytidine deaminase APOBEC3B (A3B) is an endogenous inducer of somatic mutations and causes chromosomal instability by converting cytosine to uracil in single-stranded DNA. Therefore, identification factors mechanisms that mediate A3B expression will be helpful for developing therapeutic approaches decrease DNA mutagenesis. Arsenic (As) one well-known mutagen carcinogen, but the which it induces have not been fully elucidated. Herein, we show upregulated required As-induced damage We found As treatment a N6-methyladenosine (m6A) modification near stop codon A3B, consequently increasing stability mRNA. further reveal demethylase FTO responsible As-reduced m6A leading increased mutation rates manner dependent on reader YTHDF2. Our vivo data also confirm downstream target As-exposed lung tissues. In addition, protein highly expressed positively correlates with levels tumor samples from human non-small cell cancer patients. These findings indicate previously unrecognized role As-triggered might open new avenues reduce mutagenesis targeting FTO/m6A axis.

Язык: Английский

Mechanistic understanding of the toxic effects of arsenic and warfare arsenicals on human health and environment DOI Creative Commons
Suhail Muzaffar, Jasim Khan,

Ritesh K. Srivastava

и другие.

Cell Biology and Toxicology, Год журнала: 2022, Номер 39(1), С. 85 - 110

Опубликована: Апрель 1, 2022

Abstract Worldwide, more than 200 million people are estimated to be exposed unsafe levels of arsenic. Chronic exposure groundwater arsenic is responsible for multiple human disorders, including dermal, cardiovascular, neurological, pulmonary, renal, and metabolic conditions. Consumption rice seafood (where high accumulated) also The toxicity compounds varies greatly may depend on their chemical form, solubility, concentration. Surprisingly, synthetic organoarsenicals extremely toxic molecules which created interest in development as warfare agents (CWAs) during World War I (WWI). Among these CWAs, adamsite, Clark I, II, lewisite critical importance, stockpiles still exist worldwide. In addition, unused WWII weaponized arsenicals discarded water bodies or buried many parts the world continue pose a serious threat environment health. Metabolic inhibition, oxidative stress, genotoxicity, epigenetic alterations micro-RNA-dependent regulation some underlying mechanisms toxicity. Mechanistic understanding effective therapeutic interventions. This review provides comprehensive details assessment recently published data various forms arsenic, exposure, implications environmental Graphical abstract

Язык: Английский

Процитировано

80
Recent advances in biochar amendments for immobilization of heavy metals in an agricultural ecosystem: A systematic review DOI
Saloni Sachdeva, Rakesh Kumar, Prafulla Kumar Sahoo

и другие.

Environmental Pollution, Год журнала: 2023, Номер 319, С. 120937 - 120937

Опубликована: Янв. 3, 2023

Язык: Английский

Процитировано

62
Update of the risk assessment of inorganic arsenic in food DOI Creative Commons

Dieter Schrenk,

Margherita Bignami,

Laurent Bodin

и другие.

EFSA Journal, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 1, 2024

The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard of inorganic (iAs) and using the revised exposure issued by 2021. Epidemiological studies show that chronic intake iAs via diet and/or drinking water is associated with increased several adverse outcomes including cancers skin, bladder lung. CONTAM Panel used benchmark dose lower confidence limit based response (BMR) 5% (relative increase background incidence after adjustment for confounders, BMDL05) 0.06 μg iAs/kg bw per day obtained from study skin cancer as Reference Point (RP). Inorganic As genotoxic carcinogen additional epigenetic effects applied margin (MOE) approach characterisation. In adults, MOEs are low (range between 2 0.4 mean consumers 0.9 0.2 at 95th percentile exposure, respectively) such raise health concern despite uncertainties.

Язык: Английский

Процитировано

56
Toxicity of inorganic arsenic to animals and its treatment strategies DOI

Qian Su,

Ying He,

Hang Pan

и другие.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2023, Номер 271, С. 109654 - 109654

Опубликована: Май 23, 2023

Язык: Английский

Процитировано

42
Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis DOI Creative Commons

Priya Wadgaonkar,

Fei Chen

Seminars in Cancer Biology, Год журнала: 2021, Номер 76, С. 258 - 266

Опубликована: Апрель 6, 2021

Arsenic exposure in contaminated drinking water is a global health issue, as more than 200 million people are affected globally. has been known to cause skin, liver, lung, bladder and prostate cancers. Accordingly, it categorized group I human carcinogen by the International Agency for Research on Cancer (IARC). Various natural anthropogenic activities lead release of arsenic environment, contaminating air, food sources. Traditionally, genetic mutations have center cancer research. However, emerging studies now focused importance epigenetics, metabolism endoplasmic reticulum (ER) stress cancer. highly capable inducing cells via generation free radicals causing oxidative stress, epigenetic alterations, mitochondrial dysfunction, activation intracellular signaling pathways, impairment autophagy DNA repair systems. The able utilize unfolded protein response (UPR) overcome these internal stresses various stages arsenic-induced carcinogenesis, from growth immune responses. UPR an evolutionarily conserved that both survival apoptotic outcomes. PERK, IRE1α ATF6α three ER sensors activated maintain cellular proteostasis, which can also promote apoptosis prolonged stress. dual nature different types challenge researchers. We must investigate role connections among stress-associated UPR, dysfunction malignancies identify key targets prevention therapeutics.

Язык: Английский

Процитировано

97
Understanding arsenic toxicity: Implications for environmental exposure and human health DOI Creative Commons

Ravidarshdeep Kaur,

Atul Garkal, Lopmudra P. Sarode

и другие.

Journal of Hazardous Materials Letters, Год журнала: 2023, Номер 5, С. 100090 - 100090

Опубликована: Ноя. 4, 2023

Arsenic is a trace element and metalloid which prominently known as an environmental hazard. At present, rising health apprehensions are linked to emanating from wide array of industrial, chemical, residential, agricultural, technological sources, leading extensive pollution water, soil, air ecosystems including flora, fauna humans. It poses significant harm biological organisms upon acute chronic exposure. In this review, we delve into the reported experimental data that elaborates on arsenic toxicant, with particular emphasis its occurrence, metabolism diverse molecular mechanisms involved. also includes major systemic toxicity special shedding light intricate ways it disrupts nervous system.

Язык: Английский

Процитировано

40
Arsenic and chromium induced hepatotoxicity in zebrafish (Danio rerio) at environmentally relevant concentrations: Mixture effects and involvement of Nrf2-Keap1-ARE pathway DOI

Sreejata Kamila,

Koushik Kumar Dey,

Shehnaz Islam

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 921, С. 171221 - 171221

Опубликована: Фев. 24, 2024

Язык: Английский

Процитировано

12
Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins DOI
Xixi Zhou, Rachel M. Speer, Lindsay Volk

и другие.

Seminars in Cancer Biology, Год журнала: 2021, Номер 76, С. 86 - 98

Опубликована: Май 10, 2021

Язык: Английский

Процитировано

53
Arsenic-protein interactions as a mechanism of arsenic toxicity DOI

Cristian A. Vergara-Gerónimo,

Alfonso León‐Del‐Río, Mauricio Rodríguez‐Dorantes

и другие.

Toxicology and Applied Pharmacology, Год журнала: 2021, Номер 431, С. 115738 - 115738

Опубликована: Окт. 4, 2021

Язык: Английский

Процитировано

51
Bio-inspired membranes for adsorption of arsenic via immobilized L-Cysteine in highly hydrophilic electrospun nanofibers DOI Creative Commons
David Picón, Nicolás Torasso, José Roberto Vega‐Baudrit

и другие.

Process Safety and Environmental Protection, Год журнала: 2022, Номер 185, С. 108 - 118

Опубликована: Июнь 30, 2022

Arsenic is a concern for its ubiquity in the environment and accumulative toxic properties. Water often contaminated with this chemical, so developing simple, scalable, green water treatment technologies urgently needed. We show here that ability of L-Cysteine biomolecule to form complexes arsenic inspires use as natural bio-inspired sorbent develop advanced functional materials. establish first time way chemically anchor (L-Cys) inside highly hydrophilic nanofibers create membrane capable lowering As(V) concentration below WHO limit 10 μg/L. A homogeneous precursor mixture an aqueous solution PVA L-Cys (5 wt% respect PVA) was electrospun obtain nanofibrous membrane. Successful immobilization within achieved during heat at 190 °C. It occurs through esterification reactions between hydroxyl group on chain carboxylic acid L-Cys. sorption (as As(V)) assessed by batch experiments media controlled pH range. The maximum removal efficiency 7, supporting formation thiolate primary mechanism sorption. confinement makes diffusion rate-limiting process adsorption kinetics, following pseudo order equation. Overall, work establishes novel remediation strategy encourages research nature-mimicking adsorbents biodegradable polymers materials remediation.

Язык: Английский

Процитировано

37