ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(13), P. 15718 - 15729
Published: March 20, 2024
Surgical
removal
of
tumor
tissue
remains
the
primary
clinical
approach
for
addressing
breast
cancer;
however,
complete
excision
is
challenging,
and
remaining
cells
can
lead
to
recurrence
metastasis
over
time,
which
substantially
deteriorates
life
quality
patients.
With
aim
improve
local
cancer
radiotherapy,
this
work
reports
fabrication
alginate
(Alg)
scaffolds
containing
bovine
serum
albumin
(BSA)-coated
bismuth
sulfide
(Bi2S3@BSA)
nanoradiosensitizers
using
three-dimensional
(3D)
printing.
Under
single-dose
X-ray
irradiation
in
vitro,
Alg-Bi2S3@BSA
significantly
increase
formation
reactive
oxygen
species,
enhance
inhibition
cells,
suppress
their
colony
capacity.
In
addition,
implanted
under
murine
model
show
high
therapeutic
efficacy
by
reducing
volume
growth
rate
irradiation,
while
histological
observation
main
organs
reveals
no
cytotoxicity
or
side
effects.
3D-printed
produced
with
biocompatible
biodegradable
materials
may
potentially
lower
rates
patients
inhibiting
residual
following
postsurgery
as
well
exhibit
anticancer
properties
other
solid
tumors.
Nano Convergence,
Journal Year:
2021,
Volume and Issue:
8(1)
Published: Nov. 2, 2021
Modern
medicine
has
been
waging
a
war
on
cancer
for
nearly
century
with
no
tangible
end
in
sight.
Cancer
treatments
have
significantly
progressed,
but
the
need
to
increase
specificity
and
decrease
systemic
toxicities
remains.
Early
diagnosis
holds
key
improving
prognostic
outlook
patient
quality
of
life,
diagnostic
tools
are
cusp
technological
revolution.
Nanotechnology
steadily
expanded
into
reaches
chemotherapy,
radiotherapy,
diagnostics,
imaging,
demonstrating
capacity
augment
each
advance
care.
Nanomaterials
provide
an
abundance
versatility,
functionality,
applications
engineer
specifically
targeted
medicine,
accurate
early-detection
devices,
robust
imaging
modalities,
enhanced
radiotherapy
adjuvants.
This
review
provides
insights
current
clinical
pre-clinical
nanotechnological
drug
therapy,
radiation
therapy.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(9), P. 15471 - 15483
Published: Aug. 18, 2022
Both
T-cell
deprivation
and
insufficient
tumor
immunogenicity
seriously
hinder
the
efficacy
of
immune-mediated
destruction
in
melanoma.
In
this
work,
an
amphiphilic
polyethylene
glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane)
copolymer
with
a
thermally
sensitive
flowable
core
(mPEG-b-PHEP)
was
chosen
to
incorporate
IR780
dye
manganese
zinc
sulfide
nanoparticles
(ZMS)
form
polymer
micelles
(denoted
PPIR780-ZMS),
which
precisely
controlled
release
ZMS
after
being
triggered
by
near-infrared
light
(NIR).
Mn2+-mediated
chemodynamic
therapy
(CDT)
photothermal
trigger
boosted
generation
reactive
oxygen
species
(ROS),
making
PPIR780-ZMS
smart
bomblets
vivo.
It
demonstrated
that
could
maximize
immunogenic
cell
death
(ICD)
cancer,
is
characterized
abundant
damage-associated
molecular
pattern
(DAMP)
exposure.
As
result,
cytotoxic
T
cells
(CD8+)
helper
(CD4+)
expanded
infiltrated
neoplastic
foci,
further
reprogrammed
suppressive
microenvironment
(TME)
against
primary
pulmonary
metastases
safe
systemic
cytokine
expression.
addition,
cGAS-STING
signaling
pathway
activation
enhanced
antitumor
immunity
nanocomposite,
providing
practical
strategy
for
expanding
use
Mn-based
nanostructures.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1796 - 1796
Published: June 23, 2023
Triple
negative
breast
cancer
(TNBC)
has
a
expression
of
estrogen
receptors
(ER),
progesterone
(PR),
and
human
epidermal
growth
factor
(HER2).
The
survival
rate
for
TNBC
is
generally
worse
than
other
subtypes.
treatment
made
significant
advances,
but
certain
limitations
remain.
Treatment
can
be
challenging
since
the
disease
various
molecular
A
variety
options
are
available,
such
as
chemotherapy,
immunotherapy,
radiotherapy,
surgery.
Chemotherapy
most
common
these
options.
treated
with
systemic
chemotherapy
using
drugs
anthracyclines
taxanes
in
neoadjuvant
or
adjuvant
settings.
Developing
resistance
to
anticancer
off-target
toxicity
primary
hindrances
chemotherapeutic
solutions
cancer.
It
imperative
that
researchers,
clinicians,
pharmaceutical
companies
work
together
develop
effective
TNBC.
Several
studies
have
suggested
nanotechnology
potential
solution
problem
suboptimal
treatment.
In
this
review,
we
summarized
possible
TNBC,
including
targeted
therapy,
combination
nanoparticle-based
some
future.
Moreover,
gave
general
information
about
terms
its
characteristics
aggressiveness.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
17, P. 49 - 70
Published: Feb. 1, 2022
As
a
kind
of
nature-derived
bioactive
materials,
polyphenol-based
hydrogels
possess
many
unique
and
outstanding
properties
such
as
adhesion,
toughness,
self-healing
due
to
their
specific
crosslinking
structures,
which
have
been
widely
used
in
biomedical
fields
including
wound
healing,
antitumor,
treatment
motor
system
injury,
digestive
disease,
oculopathy,
bioelectronics.
In
this
review,
starting
with
the
classification
common
hydrogels,
pyramid
evolution
process
from
structures
derived
then
applications
is
elaborated,
well
efficient
reverse
design
considerations
hydrogel
systems
are
proposed.
Finally,
existing
problems
development
prospects
these
materials
discussed.
It
hoped
that
perspective
review
can
promote
further
innovation
breakthroughs
future.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(23), P. 23223 - 23261
Published: Dec. 2, 2023
Stimuli-responsive
polymers
can
respond
to
internal
stimuli,
such
as
reactive
oxygen
species
(ROS),
glutathione
(GSH),
and
pH,
biological
enzymes,
external
lasers
ultrasound,
etc.,
by
changing
their
hydrophobicity/hydrophilicity,
degradability,
ionizability,
thus
have
been
widely
used
in
biomedical
applications.
Due
the
characteristics
of
tumor
microenvironment
(TME),
stimuli-responsive
that
cater
specifically
TME
extensively
prepare
smart
nanovehicles
for
targeted
delivery
therapeutic
diagnostic
agents
tissues.
Compared
conventional
drug
nanosystems,
TME-responsive
nanosystems
many
advantages,
high
sensitivity,
broad
applicability
among
different
tumors,
functional
versatility,
improved
biosafety.
In
recent
years,
a
great
deal
research
has
devoted
engineering
efficient
polymeric
significant
improvement
made
both
cancer
diagnosis
therapy.
this
review,
we
summarize
some
advances
involving
use
polymer
nanocarriers
delivery,
imaging,
therapy,
theranostics.
Various
chemical
stimuli
will
be
described
context
nanosystems.
Accordingly,
groups
responsible
responsiveness
strategies
incorporate
these
into
discussed
detail.
With
on
topic
expending
at
fast
pace,
innovative
concepts,
sequential
cascade
release,
NIR-II
multifunctional
formulations,
emerged
popular
enhanced
performance,
which
also
included
here
with
up-to-date
illustrations.
We
hope
review
offer
valuable
insights
selection
optimization
help
accelerate
future
applications
treatment.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(13), P. 2601 - 2601
Published: June 27, 2022
Passive
targeting
is
the
foremost
mechanism
by
which
nanocarriers
and
drug-bearing
macromolecules
deliver
their
payload
selectively
to
solid
tumors.
An
important
driver
of
passive
enhanced
permeability
retention
(EPR)
effect,
cornerstone
most
carrier-based
tumor-targeted
drug
delivery
efforts.
Despite
huge
number
publications
showcasing
successes
in
preclinical
animal
models,
translation
clinic
has
been
poor,
with
only
a
few
nano-based
drugs
currently
being
used
for
treatment
cancers.
Several
barriers
factors
have
adduced
low
efficiency
tumors
poor
clinical
translation,
including
characteristics
macromolecules,
vascular
physiological
barriers,
heterogeneity
tumor
blood
supply
affects
homogenous
distribution
within
tumors,
transport
penetration
depth
nanoparticles
matrix.
To
address
challenges
associated
therapeutic
efficacy
humans,
identified
that
affect
effect
macromolecular
therapeutics
nanoparticle
systems
need
be
overcome.
In
this
review,
approaches
facilitate
improved
EPR
outcomes
novel
are
discussed.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Aug. 25, 2023
Precise
and
efficient
image-guided
immunotherapy
holds
great
promise
for
cancer
treatment.
Here,
we
report
a
self-accelerated
nanoplatform
combining
an
aggregation-induced
emission
luminogen
(AIEgen)
hypoxia-responsive
prodrug
multifunctional
combination
immunotherapy.
The
near-infrared
AIEgen
with
methoxy
substitution
simultaneously
possesses
boosted
fluorescence
photoacoustic
(PA)
brightness
the
strong
light
absorption
ability,
as
well
amplified
type
I
II
photodynamic
therapy
(PDT)
properties
via
enhanced
intersystem
crossing
process.
By
formulating
high-performance
paclitaxel
(PTX)
into
nanoparticles,
further
camouflaging
macrophage
cell
membrane,
tumor-targeting
theranostic
agent
is
built.
integration
of
PA
imaging
helps
to
delineate
tumor
site
sensitively,
providing
accurate
guidance
light-induced
PDT
effect
could
consume
local
oxygen
lead
severer
hypoxia,
accelerating
release
PTX
drug.
As
result,
chemotherapy
induces
immunogenic
death,
which
not
only
elicit
antitumor
immunity
suppress
primary
tumor,
but
also
inhibit
growth
distant
in
4T1
tumor-bearing
female
mice.
strategy
develop
agents
rational
molecular
design
boosting
