Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5505 - 5616

Опубликована: Апрель 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Язык: Английский

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In-Cell Structural Biology by NMR: The Benefits of the Atomic Scale

Chemical Reviews, Год журнала: 2022, Номер 122(10), С. 9497 - 9570

Опубликована: Март 31, 2022

In-cell structural biology aims at extracting information about proteins or nucleic acids in their native, cellular environment. This emerging field holds great promise and is already providing new facts outlooks of interest both fundamental applied levels. NMR spectroscopy has important contributions on this stage: It brings a broad variety nuclei the atomic scale, which ensures its versatility uniqueness. Here, we detail methods, knowledge, applications biomedical engineering related to in-cell by NMR. We finally propose brief overview main other techniques (EPR, smFRET, cryo-ET, etc.) draw some advisable developments for In era large-scale screenings deep learning, accurate qualitative experimental evidence are as essential ever understand interior life cells. can generate such it does so scale. review meant deliver comprehensive but accessible information, with advanced technical details reflections nature results, future field.

Язык: Английский

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The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics

Chemical Reviews, Год журнала: 2023, Номер 123(12), С. 7782 - 7853

Опубликована: Май 15, 2023

The high selectivity and affinity of antibodies toward their antigens have made them a highly valuable tool in disease therapy, diagnosis, basic research. A plethora chemical genetic approaches been devised to make accessible more "undruggable" targets equipped with new functions illustrating or regulating biological processes precisely. In this Review, addition introducing how naked various antibody conjugates (such as antibody-drug conjugates, antibody-oligonucleotide antibody-enzyme etc.) work therapeutic applications, special attention has paid chemistry tools helped optimize the outcome (i.e., enhanced efficacy reduced side effects) facilitate multifunctionalization antibodies, focus on emerging fields such targeted protein degradation, real-time live-cell imaging, catalytic labeling decaging spatiotemporal control well engagement inside cells. With advances modern biotechnology, well-designed derivatives via size miniaturization together efficient delivery systems emerged, which gradually improved our understanding important paved way pursue novel for potential treatments diseases.

Язык: Английский

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Microfluidic formulation of anticancer peptide loaded ZIF-8 nanoparticles for the treatment of breast cancer

Journal of Colloid and Interface Science, Год журнала: 2023, Номер 642, С. 810 - 819

Опубликована: Март 30, 2023

Язык: Английский

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Recent Advances in pH and Redox Responsive Polymer Nanocomposites for Cancer Therapy

Journal of Composites Science, Год журнала: 2024, Номер 8(1), С. 28 - 28

Опубликована: Янв. 11, 2024

Cancer therapy currently focuses on personalized targeted treatments. A promising approach uses stimuli-responsive biomaterials for site-specific drug release, such as pH- and redox-triggered polymer nanocomposites. These materials respond to the tumor microenvironment, enhance efficacy, reduce off-target effects. cells with anomalous properties acidic cytosolic pH elevated redox potential are by these biomaterials. An imbalance in ions biological thiols cytoplasm contributes growth. Functionalized nanocomposites large surface areas specific targeting outperform conventional small-molecule materials. To overcome problems low bioavailability, uncontrolled poor cell penetration, multifunctional nanomaterials make it easier drugs enter certain cellular or subcellular systems. High therapeutic efficacy is achieved through functionalization, targeting, use of components. In particular, dual-stimuli-based polymeric cancer therapeutics have scarcely been reported. This article provides recent progress redox-responsive delivery therapy. It explores design principles, fabrication methods, mechanisms action, prospects dual-stimuli-responsive

Язык: Английский

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Amphiphilic Poly(ethylene glycol)-Cholesterol Conjugate: Stable Micellar Formulation for Efficient Loading and Effective Intracellular Delivery of Curcumin

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

A biodegradable and biocompatible micellar-based drug delivery system was developed using amphiphilic methoxy-poly(ethylene glycol)-cholesterol (C1) poly(ethylene glycol)-S-S-cholesterol (C2) conjugates applied to the tumoral release of water-insoluble curcumin. These synthesized surfactants C1 C2 were found form stable micelles (CMC ∼ 6 μM) an average hydrodynamic size around 20-25 nm. The curcumin-encapsulated micelle formulated by a solvent evaporation method. very high encapsulation efficiency (EE) ∼88% loading (DL) capacity ∼9% determined for both micelles. From reduced rate curcumin degradation differential scanning calorimetry (DSC) analysis, stability curcumin-loaded be higher than that unloaded micelle, which confirmed more compact structural arrangement in presence hydrophobic pH-sensitive (faster with decrease pH) observed attributed diffusion relaxation/erosion micellar aggregates. To achieve reduction environment-sensitive release, disulfide (S-S) chemical linkage-incorporated mPEG-cholesterol conjugate synthesized, show glutathione-responsive faster vitro experiments carried out SCC9 oral cancer cell lines showed blank noncytotoxic at lower concentrations (<50 μM), while inhibited proliferation promoted apoptosis. An increased cytotoxicity compared itself, demonstrating better penetration efficacy micelle. results further supplemented vivo anticancer analysis formulations mice xenograft model. Notably, significantly stronger apoptotic effect micelles, indicating GSH improved bioavailability. In conclusion, advantages small size, efficiency, loading, simple preparing technique, biocompatibility, good performance may have potential used as carrier sustained stimuli-responsive

Язык: Английский

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Glycopolymer-Based Materials: Synthesis, Properties, and Biosensing Applications

Topics in Current Chemistry, Год журнала: 2022, Номер 380(5)

Опубликована: Авг. 11, 2022

Язык: Английский

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Silk sericin-based biomaterials shine in food and pharmaceutical industries

Smart Materials in Medicine, Год журнала: 2023, Номер 4, С. 447 - 459

Опубликована: Янв. 1, 2023

Silk sericin (SS) is a byproduct of the silk production process that consists 18 ​amino acids and numerous polar groups. SS has range unique physical, chemical, biological properties, such as mechanical strength, antioxidant activity, pH responsiveness, low immunogenicity, biocompatibility, ability to promote cell proliferation. These properties make useful in various fields, including food biomedicine. It can also be easily modified into biomaterials through cross-linking, copolymerization, combination with other polymers. This review summarizes potential applications SS-based biomedicine industries, additives, packaging, vitro/vivo monitoring, drug delivery systems, wound healing. In addition, future development possibilities or are discussed.

Язык: Английский

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Protein and Peptide‐Based Nanotechnology for Enhancing Stability, Bioactivity, and Delivery of Anthocyanins

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(25)

Опубликована: Авг. 3, 2023

Anthocyanin, a unique natural polyphenol, is abundant in plants and widely utilized biomedicine, cosmetics, the food industry due to its excellent antioxidant, anticancer, antiaging, antimicrobial, anti-inflammatory properties. However, degradation of anthocyanin an extreme environment, such as alkali pH, high temperatures, metal ions, limits physiochemical stabilities bioavailabilities. Encapsulation combining with biomaterials could efficiently stabilize for protection. Promisingly, or artificially designed proteins peptides favorable stabilities, biocapacity, wide sources are potential candidates anthocyanin. This review focuses on recent progress, strategies, perspectives protein peptide functionalization delivery, i.e., formulation technologies, physicochemical stability enhancement, cellular uptake, bioavailabilities, biological activities development. Interestingly, simplicity diversity structure, interaction mechanisms between be illustrated. work sheds light mechanism protein/peptide-anthocyanin nanoparticle construction expands applications nutrition biomedicine.

Язык: Английский

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From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapy

Bioactive Materials, Год журнала: 2023, Номер 31, С. 206 - 230

Опубликована: Авг. 14, 2023

Traditional cancer therapy methods, especially those directed against specific intracellular targets or signaling pathways, are not powerful enough to overcome tumor heterogeneity and therapeutic resistance. Oncolytic peptides that can induce membrane lysis-mediated cell death subsequent anticancer immune responses, has provided a new paradigm for therapy. However, the clinical application of oncolytic is always limited by some factors such as unsatisfactory bio-distribution, poor stability, off-target toxicity. To these limitations, polymers stand out prospective materials owing their high chemical versatility, scalable production capacity, which potential drive revolution in treatment. This review provides an overview mechanism structure-activity relationship peptides. Then peptides-mediated combination nano-delivery strategies summarized. Emphatically, current research progress been highlighted. Lastly, challenges prospects development discussed.

Язык: Английский

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