Metallothionein-2: An emerging target in inflammatory diseases and cancers

Pharmacology & Therapeutics, Год журнала: 2023, Номер 244, С. 108374 - 108374

Опубликована: Март 6, 2023

Язык: Английский

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Peptides and metal ions: A successful marriage for developing artificial metalloproteins

Journal of Peptide Science, Год журнала: 2024, Номер unknown

Опубликована: Май 8, 2024

The mutual relationship between peptides and metal ions enables metalloproteins to have crucial roles in biological systems, including structural, sensing, electron transport, catalytic functions. effort reproduce or/and enhance these roles, or even create unprecedented functions, is the focus of protein design, first step toward comprehension complex machinery nature. Nowadays, design allows building sophisticated scaffolds, with novel functions exceptional stability. Recent progress metalloprotein has led peptides/proteins capable orchestrating desired different cofactors. structural diversity proper selection first- second-shell ligands, as well long-range electrostatic hydrophobic interactions, which represent precious tools for tuning properties. scope this review discuss construction sites de novo designed miniaturized scaffolds. Selected examples mono-, di-, multi-nuclear binding sites, from last 20 years will be described an highlight key artificial models electron-transfer metalloproteins. authors' goal make readers feel like guests at marriage while offering sources inspiration future architects innovative,

Язык: Английский

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The arcana of zinc

Journal of Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Cysteine-based biomolecules regulate cellular copper- and redox-homeostasis

Coordination Chemistry Reviews, Год журнала: 2025, Номер 529, С. 216442 - 216442

Опубликована: Янв. 13, 2025

Язык: Английский

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Targeting mineral metabolism in cancer: Insights into signaling pathways and therapeutic strategies

Seminars in Cancer Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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