Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 244, P. 108374 - 108374
Published: March 6, 2023
Language: Английский
Citations
14
Journal of Peptide Science, Journal Year: 2024, Volume and Issue: unknown
Published: May 8, 2024
The mutual relationship between peptides and metal ions enables metalloproteins to have crucial roles in biological systems, including structural, sensing, electron transport, catalytic functions. effort reproduce or/and enhance these roles, or even create unprecedented functions, is the focus of protein design, first step toward comprehension complex machinery nature. Nowadays, design allows building sophisticated scaffolds, with novel functions exceptional stability. Recent progress metalloprotein has led peptides/proteins capable orchestrating desired different cofactors. structural diversity proper selection first- second-shell ligands, as well long-range electrostatic hydrophobic interactions, which represent precious tools for tuning properties. scope this review discuss construction sites de novo designed miniaturized scaffolds. Selected examples mono-, di-, multi-nuclear binding sites, from last 20 years will be described an highlight key artificial models electron-transfer metalloproteins. authors' goal make readers feel like guests at marriage while offering sources inspiration future architects innovative,
Language: Английский
Citations
5
Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216442 - 216442
Published: Jan. 13, 2025
Language: Английский
Citations
0
Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0