Current research trends of nanomedicines

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(11), С. 4391 - 4416

Опубликована: Май 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Язык: Английский

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Achieving Fast Charge Separation by Ferroelectric Ultrasonic Interfacial Engineering for Rapid Sonotherapy of Bacteria‐Infected Osteomyelitis

Advanced Materials, Год журнала: 2023, Номер 35(13)

Опубликована: Янв. 10, 2023

Bacteria-infected osteomyelitis is life-threatening without effective therapeutic methods clinically. Here, a rapid and strategy to treat through ferroelectric polarization interfacial engineering of BiFeO3 /MXene (Ti3 C2 ) triggered by ultrasound (US) reported. Under US, the induces formation piezoelectric field. US cavitation effect induced sonoluminescence stimulates /Ti3 produce photogenerated carriers. With synergistic action electric field Schottky junction, accelerates separation electrons holes simultaneously inhibits backflow electrons, thus improving utilization polarized charges consequently enhancing yield reactive oxygen species under US. As result, 99.87 ± 0.05% Staphylococcus aureus are efficiently killed in 20 min with assistance ultrasonic heating. The theory proposed, which brings new insight for developing responsive materials used diagnosis therapy deep tissue infection other acoustoelectric devices.

Язык: Английский

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Ultrasound technology and biomaterials for precise drug therapy

Materials Today, Год журнала: 2023, Номер 63, С. 210 - 238

Опубликована: Янв. 9, 2023

Язык: Английский

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Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

Chemical Society Reviews, Год журнала: 2023, Номер 52(17), С. 6191 - 6220

Опубликована: Янв. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Язык: Английский

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Compact holographic sound fields enable rapid one-step assembly of matter in 3D

Science Advances, Год журнала: 2023, Номер 9(6)

Опубликована: Фев. 8, 2023

Acoustic waves exert forces when they interact with matter. Shaping ultrasound fields precisely in 3D thus allows control over the force landscape and should permit particulates to fall into place potentially form whole objects "one shot." This is promising for rapid prototyping, most notably biofabrication, since conventional methods are typically slow apply mechanical or chemical stress on biological cells. Here, we realize generation of compact holographic demonstrate one-step assembly matter using acoustic forces. We combine multiple that drive contactless solid microparticles, hydrogel beads, cells inside standard labware. The structures can be fixed via gelation surrounding medium. In contrast previous work, this approach handles positive does not require opposing waves, supporting surfaces scaffolds. envision applications tissue engineering additive manufacturing.

Язык: Английский

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Dual-Responsive Triple-Synergistic Fe-MOF for Tumor Theranostics

ACS Nano, Год журнала: 2023, Номер 17(10), С. 9003 - 9013

Опубликована: Апрель 28, 2023

The intelligent responsive drug delivery system has great application potential in cancer precision therapy. Although many antitumor methods have been developed based on systems, most of them yet suffer from poor efficiency. In this project, a near-infrared and pH dual-response multimodal collaborative platform for diagnosis treatment (PCN-DOX@PDA) was constructed. We used PCN-600 as vehicle loaded with antineoplastic drugs polydopamine (PDA). Under 633 nm laser irradiation, the ligand tetrakis(4-carboxyphenyl)porphyrin (TCPP) can generate singlet oxygen (1O2) kill tumor cells. PDA is photothermal agent PTT. PCN-DOX@PDA achieves release by responding to weak acidity microenvironment thermal stimulation generated NIR irradiation. addition, since central ion PCN Fe3+, realizes tumors through magnetic resonance imaging-mediated chemotherapy photodynamic synergistic This triple strategy showed excellent biocompatibility ability vivo experiments 4T1 tumor-bearing mouse model, indicating that good development prospect field therapy diversified biomedical applications.

Язык: Английский

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A Diagnostic and Therapeutic Hydrogel to Promote Vascularization via Blood Sugar Reduction for Wound Healing

Advanced Functional Materials, Год журнала: 2023, Номер 33(14)

Опубликована: Янв. 15, 2023

Abstract Chronic hyperglycemic damage is a major problem that undermines diabetic wound healing. By combining treatment and diagnosis together, blood glucose concentration can be monitored real‐time through medical imaging devices precise interventions carried out at the right time to promote repair. In this study, an injectable self‐healing hyaluronic acid hydrogel constructed using Schiff base reaction, nanoenzymes (GOx‐MnO 2 ) synthesized by condensation along with vascular endothelial growth factor (VEGF)‐nanobubbles produced double emulsification method, are loaded into hydrogel, thus constructing innovative diagnostic therapeutic system (US@GOx@VEGF UGV hydrogel). While monitoring in real‐time, delivers VEGF ultrasound noninvasive way deplete glucose. The integrates both processes of treatment, effectively releases blasts triggered ultrasound. Apart from this, new trauma patch capable Mn 2+ values ranging 0.5 m 7.8 × 10 −3 levels 100 3 , magnetic resonance imaging. summary, realizes level, maintains homeostasis intervention, rapidly promotes repair skin defects, opening up path for chronic management.

Язык: Английский

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Advanced supramolecular design for direct ink writing of soft materials

Chemical Society Reviews, Год журнала: 2023, Номер 52(5), С. 1614 - 1649

Опубликована: Янв. 1, 2023

This review draws connections between top-down direct-ink-writing and bottom-up supramolecular designs. Examples of supramolecularly designed viscoelastic inks perspectives using motifs for 3D printing have been discussed.

Язык: Английский

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Bimetallic Organic Frameworks of High Piezovoltage for Sono‐Piezo Dynamic Therapy

Advanced Materials, Год журнала: 2023, Номер 35(41)

Опубликована: Июль 11, 2023

Piezoelectric materials produce charges to directly act on cancer medium or promote the generation of reactive oxygen species (ROS) for novel tumor therapy triggered by sonography. Currently, piezoelectric sonosensitizers are mainly used catalyze ROS band-tilting effect sonodynamic therapy. However, it remains a challenge high piezovoltages overcome bandgap barrier direct charge generation. Herein, Mn-Ti bimetallic organic framework tetragonal nanosheets (MT-MOF TNS) designed sono-piezo (SP)-dynamic (SPDT) with remarkable antitumor efficacy in vitro and vivo. The MT-MOF TNS comprise non-centrosymmetric secondary building units Mn-Ti-oxo cyclic octamers heterogeneous components piezoelectricity. promotes strong sonocavitation induce SP voltage (2.9 V) situ, excite charges, which is validated SP-excited luminescence spectrometry. depolarize mitochondrial plasma membrane potentials cause overproduction serious cell damage. Importantly, can be decorated targeting molecules chemotherapeutics more severe regression combining SPDT chemodynamic chemotherapy. This report develops fascinating nano-semiconductor provides an efficient strategy treatment.

Язык: Английский

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The fundamentals and applications of piezoelectric materials for tumor therapy: recent advances and outlook

Materials Horizons, Год журнала: 2023, Номер 10(4), С. 1140 - 1184

Опубликована: Янв. 1, 2023

Malignant tumors are one of the main diseases leading to death, and vigorous development nanotechnology has opened up new frontiers for antitumor therapy. Currently, researchers focused on solving biomedical challenges associated with traditional anti-tumor medical methods, promoting research nano-drug carriers nano-drugs, which brings great hope improving curative effect reducing toxic side effects. Among systems being investigated, piezoelectric nano biomaterials, including ferroelectrics, pyroelectric materials, have recently received extensive attention applications. By coupling force, light, magnetism or heat electricity, polarized charges generated in these materials microscopically, forming a piezo-potential establishing built-in electric field. Polarized can directly act tumor micro-environment also assist separation inhibit recombination based theory optoelectronic theory. Based this, convert various forms primary energy (such as light energy, mechanical thermal magnetic energy) from surrounding environment into secondary electrical chemical energy). Herein, we review basic principles ferroelectric nanomedicine. Then, summarize types reported date their wide applications treatment, imaging, device construction probe detection treatment fields. discuss relevant characteristics post-processing strategies biomaterials obtain maximum response. Finally, present key future prospects ferroelectric, nanomaterial-based nanoagents efficient harvesting conversion desirable therapeutic outcomes.

Язык: Английский

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