Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(35)
Опубликована: Июнь 22, 2024
Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.
Язык: Английский
Процитировано
35
Small, Год журнала: 2024, Номер 20(25)
Опубликована: Янв. 15, 2024
Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.
Язык: Английский
Процитировано
28
Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154249 - 154249
Опубликована: Июль 30, 2024
Язык: Английский
Процитировано
18
Materials & Design, Год журнала: 2023, Номер 231, С. 112036 - 112036
Опубликована: Май 25, 2023
As the population ages, cancer has become a major health concern. Although surgical treatment, chemoradiotherapy, and other clinical treatments have dominant, their strong invasiveness intolerable toxic side effects seriously affect patients' quality of life. Therefore, developing non-invasive optical therapy with high safety is great significance. In last two decades development, progress been made in lanthanide doped nanoparticles on biomedical applications under near-infrared (NIR) light due to unique properties. These nanomaterials used wide range applications, including bioluminescence marker detection, vitro vivo imaging, photodynamic (PDT), photothermal (PTT), therapeutic applications. therapies rapidly developed profession involving oncology non-invasive, spatiotemporal controllability, efficiency. For this key review, based listed as follows: bioimaging, biosensors, PDT PTT. Some emerging biological lanthanide-doped currently at forefront nano/biological interface are also discussed. Finally, review summarizes future opportunities challenges nanotechnology research nanoparticles.
Язык: Английский
Процитировано
27
Applied Materials Today, Год журнала: 2024, Номер 39, С. 102332 - 102332
Опубликована: Июль 20, 2024
Язык: Английский
Процитировано
13
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(22), С. 5272 - 5298
Опубликована: Янв. 1, 2024
Bio-based polymers possess distinctive dielectric and piezoelectric properties that make them extremely attractive in a variety of biomedical applications.
Язык: Английский
Процитировано
11
Advanced Materials, Год журнала: 2024, Номер 36(24)
Опубликована: Фев. 27, 2024
Nanozyme activity is greatly weakened by the microenvironment and multidrug resistance of tumor cells. Hence, a bi-catalytic nanoplatform, which promotes anti-tumor through "charging empowerment" "mutual complementation" processes involved in enzymatic pyroelectric catalysis, loading ultra-small nanoparticles (USNPs) ZnSnO
Язык: Английский
Процитировано
9
Small, Год журнала: 2024, Номер 20(25)
Опубликована: Янв. 10, 2024
Abstract Cellular senescence, a vulnerable state of growth arrest, has been regarded as potential strategy to weaken the resistance tumor cells, leading dramatic improvements in treatment efficacy. However, selective and efficient for inducing local cellular senescence not yet reported. Herein, piezoelectric catalysis is utilized reduce intracellular NAD + NADH cell first time. In detail, biocompatible nanomedicine (BTO/Rh‐D@M) constructed by wrapping BaTiO 3 /(Cp * RhCl 2 ) (BTO/Rh) doxorubicin (DOX) homologous cytomembrane with target. After tumors are stimulated ultrasound, negative positive charges generated on BTO/Rh catalysis, which oxidize H O reactive oxygen species (ROS) mitochondrial damage. Thus, therapeutic efficacy immunogenic death‐induced chemo‐immunotherapy boosted combining DOX, ROS. The results indicate that 23.9% catalysis‐treated cells senesced, solid mice disappeared completely after therapy. Collectively, this study highlights novel realize utilizing significance improve
Язык: Английский
Процитировано
8
Advanced Science, Год журнала: 2023, Номер 11(8)
Опубликована: Ноя. 9, 2023
Abstract Near‐infrared (NIR) light is well‐suited for the optical imaging and wireless phototherapy of malignant diseases because its deep tissue penetration, low autofluorescence, weak scattering, non‐invasiveness. Rare earth nanoparticles (RENPs) are promising NIR‐responsive materials, owing to their excellent physical chemical properties. The 4f electron subshell lanthanides, main group rare elements, has rich energy‐level structures. This facilitates broad‐spectrum light‐to‐light conversion other forms energy, such as thermal energies. In addition, abundant loadable modifiable sites on surface offer favorable conditions functional expansion RENPs. this review, authors systematically discuss processes mechanisms underlying response RENPs NIR summarize recent advances in applications imaging, photothermal therapy, photodynamic photoimmunotherapy, optogenetics, light‐responsive drug release. Finally, challenges opportunities application under activation considered.
Язык: Английский
Процитировано
22
Advanced Materials Technologies, Год журнала: 2024, Номер unknown
Опубликована: Сен. 13, 2024
Abstract Piezoelectric composites have received widespread attentions in the fields of biomedicine and vitro wearable devices due to their ability convert mechanical forces into charge signals. The preparation piezoelectric with complex structures through 3D printing technology can not only effectively improve output, but also enable customized therapeutic applications. This paper first introduces types reviews commonly used preparation, analyzing advantages disadvantages each technology. Then, state‐of‐the‐art biomedical applications composites, including drug sustained‐release, wound healing promotion, bone tissue cells growth promoting, neurorehabilitation stimulating, ultrasonic diagnosis, vivo biosensing sensing, are emphasized. Finally, main factors affecting printed outlooked, an in‐depth discussion on challenges toward analyzed. review is believed provide some fundamental knowledge composites.
Язык: Английский
Процитировано
7