Journal of Industrial and Engineering Chemistry, Год журнала: 2024, Номер 134, С. 301 - 311
Опубликована: Янв. 2, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(21), С. 13116 - 13116
Опубликована: Окт. 28, 2022
The central nervous system (CNS) controls and regulates the functional activities of organ systems maintains unity between body external environment. advent co-culture has made it possible to elucidate interactions neural cells in vitro reproduce complex circuits. Here, we classified as a two-dimensional (2D) system, cell-based three-dimensional (3D) tissue slice-based 3D an organoid-based microfluidic platform-based system. We provide overview these different models their applications study cell interaction. application virus-infected CNS disease is also discussed here. Finally, direction future research prospected.
Язык: Английский
Процитировано
42
Journal of Medical Virology, Год журнала: 2024, Номер 96(2)
Опубликована: Янв. 31, 2024
Abstract Persistent infection with high‐risk types of human papillomaviruses (HPV) is a major cause cervical cancer, and an important factor in other malignancies, for example, head neck cancer. Despite recent progress screening vaccination, the incidence mortality are still relatively high, especially low‐income countries. The financial burden associated treatment could be decreased if simple, rapid, inexpensive technology HPV testing becomes available, targeting individuals further monitoring increased risk developing Commercial tests available market often expensive, time‐consuming, require sophisticated instrumentation, which limits their more widespread utilization. To address these challenges, novel technologies being implemented also diagnostics that include isothermal amplification techniques, lateral flow assays, CRISPR‐Cas‐based systems, as well microfluidics, paperfluidics lab‐on‐a‐chip devices, ideal point‐of‐care decentralized settings. In this review, we first evaluate current commercial tests, followed by description advanced technologies, explanation principles, critical evaluation strengths weaknesses, suggestions possible implementation into medical diagnostics.
Язык: Английский
Процитировано
12
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Сен. 18, 2024
Язык: Английский
Процитировано
9
Biosensors, Год журнала: 2024, Номер 14(7), С. 336 - 336
Опубликована: Июль 10, 2024
Cell co-culture technology aims to study the communication mechanism between cells and better reveal interactions regulatory mechanisms involved in processes such as cell growth, differentiation, apoptosis, other cellular activities. This is achieved by simulating complex organismic environment. Such studies are of great significance for understanding physiological pathological multicellular organisms. As an emerging cultivation technology, 3D based on microfluidic chips, can efficiently, rapidly, accurately achieve co-culture. accomplished leveraging unique microchannel structures flow characteristics chips. The simulate native microenvironment providing a new technical platform studying intercellular communication. It has been widely used research oncology, immunology, neuroscience, fields. In this review, we summarize provide insights into design systems detection methods employed systems, applications these models.
Язык: Английский
Процитировано
8
Microsystems & Nanoengineering, Год журнала: 2025, Номер 11(1)
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
1
Med-X, Год журнала: 2024, Номер 2(1)
Опубликована: Май 21, 2024
Abstract The electrical microenvironment is considered a pivotal determinant in various pathophysiological processes, including tissue homeostasis and wound healing. Consequently, extensive research endeavors have been directed toward applying electricity to cells tissues through external force devices or biomaterial-based platforms. In addition situ electroconductive matrices, new class of electroactive biomaterials responsive stimuli has emerged as focal point interest. These materials, response intrinsic biochemical (e.g., glucose) physical light, magnetism, stress), hold significant potential for cell stimulation regeneration. this communication, we underscore distinct category biomaterials, discussing the currently developed biomaterial platforms their biological roles stimulating during healing regeneration process. We also critically evaluate inherent limitations challenges these while offering forward-looking insights into promise future clinical translations. Graphical
Язык: Английский
Процитировано
6
Neuroscience, Год журнала: 2024, Номер 565, С. 63 - 79
Опубликована: Ноя. 26, 2024
Язык: Английский
Процитировано
5
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(21)
Опубликована: Янв. 13, 2024
Brain organoids are three-dimensional aggregates of self-organized differentiated stem cells that mimic the structure and function human brain regions. Organoids bridge gaps between conventional drug screening models such as planar mammalian cell culture, animal studies, clinical trials. They can revolutionize fields developmental biology, neuroscience, toxicology, computer engineering. Conventional microinstrumentation for cellular engineering, microfluidic chips; microelectrode arrays (MEAs); optical, magnetic, acoustic techniques, has limitations when applied to (3D) organoids, primarily due their limits with inherently two-dimensional geometry interfacing. Hence, there is an urgent need develop new instrumentation compatible live culture techniques scalable 3D formats relevant organoids. This review discusses approaches emerging necessary advanced organoid-machine interfaces. Specifically, this article surveys recently developed microinstrumentation, including printed curved microfluidics, fast-scan optical buckling self-folding MEAs, interfaces electrochemical measurements, spatially controllable magnetic technologies two-way information transfer highlights key challenges must be addressed robust organoid reliable spatiotemporal transfer.
Язык: Английский
Процитировано
4
Cell organoid (Print), Год журнала: 2024, Номер unknown
Опубликована: Май 1, 2024
Environmental pollutants are mainly produced by human production and living, pose a serious threat to health. Health risk assessments of environmental needed in order contribute the development reasonable control measures. In comparison two-dimensional (2D) cell culture experimental animals, organoids excellent alternative models for health assessment pollutants. this review, we described application toxicity testing Finally, there was discussion unique advantages challenges as test models. It is hoped that will provide insight into field toxicology.
Язык: Английский
Процитировано
4
Materials Today, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0