Nanotechnology in healthcare, and its safety and environmental risks DOI Creative Commons
Xiaohan Ma,

Yaxin Tian,

Yang Ren

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 15, 2024

Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract

Язык: Английский

Metal–Organic Frameworks for Biomedical Applications DOI
Jie Yang, Ying‐Wei Yang

Small, Год журнала: 2020, Номер 16(10)

Опубликована: Фев. 6, 2020

Metal-organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes functional organic ligands through bonds, have attracted extensive research interest during the past decades. Due to unique features diverse compositions, facile synthesis, easy surface functionalization, high areas, adjustable porosity, tunable biocompatibility, MOFs been widely used in hydrogen/methane storage, catalysis, biological imaging sensing, drug delivery, desalination, gas separation, magnetic electronic devices, nonlinear optics, water vapor capture, etc. Notably, with rapid development synthetic methods functionalization strategies, smart MOF-based nanocomposites advanced bio-related properties designed fabricated meet growing demands MOF materials for biomedical applications. This work outlines synthesis recent advances fields, including cargo (drugs, nucleic acids, proteins, dyes) delivery cancer therapy, bioimaging, antimicrobial, biosensing, biocatalysis. The prospects challenges field also discussed.

Язык: Английский

Процитировано

810

Reversible-deactivation radical polymerization (Controlled/living radical polymerization): From discovery to materials design and applications DOI
Nathaniel Corrigan, Kenward Jung, Graeme Moad

и другие.

Progress in Polymer Science, Год журнала: 2020, Номер 111, С. 101311 - 101311

Опубликована: Окт. 14, 2020

Язык: Английский

Процитировано

764

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy DOI
Shuang Liang, Xiaoran Deng,

Ping’an Ma

и другие.

Advanced Materials, Год журнала: 2020, Номер 32(47)

Опубликована: Окт. 16, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such deeper penetration depth, absence of phototoxicity, fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks the facile engineering nature nanotechnology, numerous novel nanoplatforms being applied this emerging field tackle these barriers achieve continuous innovations. In particular, combination other treatment strategies superior efficacy improving anticancer activity relative that monotherapies alone. Therefore, it is necessary summarize nanomaterial-assisted combinational cancer applications. Herein, design principles achieving synergistic effects based on nanomaterial methods highlighted. The ultimate goals stimulate better-quality combined schemes provide innovative ideas perspectives promoting future transformation clinical application.

Язык: Английский

Процитировано

471

Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics DOI Creative Commons
Shengzhe Zhao, Xujiang Yu,

Yuna Qian

и другие.

Theranostics, Год журнала: 2020, Номер 10(14), С. 6278 - 6309

Опубликована: Янв. 1, 2020

Multifunctional magnetic nanoparticles and derivative nanocomposites have aroused great concern for multimode imaging cancer synergistic therapies in recent years.Among the rest, functional iron oxide (Fe3O4 NPs) shown potential as an advanced platform because of their inherent resonance (MRI), biocatalytic activity (nanozyme), hyperthermia treatment (MHT), photo-responsive therapy drug delivery chemotherapy gene therapy.Magnetic Fe3O4 NPs can be synthesized through several methods easily surface modified with biocompatible materials or active targeting moieties.The MRI capacity could appropriately modulated to induce response between T1 T2 modes by controlling size distribution NPs.Besides, small-size are also desired due enhanced permeation retention (EPR) effect, thus therapeutic efficiency NP-based platforms further improved.Here, we firstly retrospect typical synthesis modification NPs.Then, latest biomedical application including responsive MRI, multimodal imaging, nanozyme, MHT, delivery, mechanism corresponding treatments cooperation therapeutics multifunctional explained.Finally, outline a brief discussion perspective on possibility clinical translations these nanomaterials.This review would provide comprehensive reference readers understand diagnosis treatment.

Язык: Английский

Процитировано

308

Advanced hybrid nanomaterials for biomedical applications DOI
Wooram Park,

Heejun Shin,

Bogyu Choi

и другие.

Progress in Materials Science, Год журнала: 2020, Номер 114, С. 100686 - 100686

Опубликована: Май 25, 2020

Язык: Английский

Процитировано

233

Janus Nanoparticles: From Fabrication to (Bio)Applications DOI
Xuan Zhang, Qinrui Fu, Hongwei Duan

и другие.

ACS Nano, Год журнала: 2021, Номер 15(4), С. 6147 - 6191

Опубликована: Март 19, 2021

Janus nanoparticles (JNPs) refer to the integration of two or more chemically discrepant composites into one structure system. Studies JNPs have been significant interest due their interesting characteristics stemming from asymmetric structures, which can integrate different functional properties and perform synergetic functions simultaneously. Herein, we present recent progress particles, comprehensively detailing fabrication strategies applications. First, classification is divided three blocks, consisting polymeric composites, inorganic hybrid polymeric/inorganic composites. Then, are alternately summarized, examining self-assembly strategy, phase separation seed-mediated polymerization, microfluidic preparation nucleation growth methods, masking methods. Finally, various intriguing applications presented, including solid surfactants agents, micro/nanomotors, biomedical such as biosensing, controlled drug delivery, bioimaging, cancer therapy, combined theranostics. Furthermore, challenges future works in this field provided.

Язык: Английский

Процитировано

203

Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles DOI
Wei Chen, Chi‐An Cheng, Emily D. Cosco

и другие.

Journal of the American Chemical Society, Год журнала: 2019, Номер 141(32), С. 12475 - 12480

Опубликована: Июль 27, 2019

Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of SWIR has been limited, part, by lack bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-Aggregation offers a means transform stable, near-infrared (NIR) fluorophores into red-shifted agents. Here we demonstrate J-aggregates NIR fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) result nanomaterials light. The PEGylated HMSNs are stable for multiple weeks buffer enable high resolution vivo with 980 nm excitation.

Язык: Английский

Процитировано

170

Copper-based metal–organic frameworks for biomedical applications DOI

Ju‐E Cun,

Fan Xi, Qingqing Pan

и другие.

Advances in Colloid and Interface Science, Год журнала: 2022, Номер 305, С. 102686 - 102686

Опубликована: Апрель 29, 2022

Язык: Английский

Процитировано

151

Inorganic–organic hybrid nanomaterials for photothermal antibacterial therapy DOI
Xiaoliang Qi,

Yajing Xiang,

Erya Cai

и другие.

Coordination Chemistry Reviews, Год журнала: 2023, Номер 496, С. 215426 - 215426

Опубликована: Сен. 6, 2023

Язык: Английский

Процитировано

136

Foliage adhesion and interactions with particulate delivery systems for plant nanobionics and intelligent agriculture DOI Creative Commons
Renato Grillo, Bruno D. Mattos,

Débora R. Antunes

и другие.

Nano Today, Год журнала: 2021, Номер 37, С. 101078 - 101078

Опубликована: Янв. 20, 2021

The constantly increasing global food demand galvanizes innovative agricultural actions aimed to transcend current production levels. predicted near-future security scenario is alarming, requiring beyond traditional practices. Following the success of nanotechnologies in pharma and health sciences, nano-enabled agriculture expected increase crop yields limit losses pathogens, pests other threats. Associated efforts are enabled by real-time sensing controlled delivery, latter which considers cargos designed for targeted release, especially if triggered on demand. In this review, we introduce recent breakthroughs these areas, including pesticide delivery as well genetic modification engineering nanoparticles application living materials. We offer a critical discussion physico-chemistry adhesion vegetal tissue, their uptake translocation within plants.

Язык: Английский

Процитировано

132