Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 15, 2024
Abstract
Nanotechnology
holds
immense
promise
in
revolutionising
healthcare,
offering
unprecedented
opportunities
diagnostics,
drug
delivery,
cancer
therapy,
and
combating
infectious
diseases.
This
review
explores
the
multifaceted
landscape
of
nanotechnology
healthcare
while
addressing
critical
aspects
safety
environmental
risks
associated
with
its
widespread
application.
Beginning
an
introduction
to
integration
we
first
delved
into
categorisation
various
materials
employed,
setting
stage
for
a
comprehensive
understanding
potential.
We
then
proceeded
elucidate
diverse
applications
nanotechnology,
spanning
medical
tissue
engineering,
targeted
gene
development
antimicrobial
agents.
The
discussion
extended
current
situation
surrounding
clinical
translation
commercialisation
these
cutting-edge
technologies,
focusing
on
nanotechnology-based
products
that
have
been
approved
globally
date.
also
discussed
considerations
nanomaterials,
both
terms
human
health
impact.
presented
vivo
nanomaterial
exposure,
relation
transport
mechanisms,
oxidative
stress,
physical
interactions.
Moreover,
highlighted
risks,
acknowledging
potential
implications
ecosystems
biodiversity.
Lastly,
strived
offer
insights
regulatory
governing
across
different
regions
globally.
By
synthesising
perspectives,
underscore
imperative
balancing
innovation
stewardship,
charting
path
forward
responsible
healthcare.
Graphical
abstract
Metal-organic
frameworks
(MOFs)
are
an
interesting
and
useful
class
of
coordination
polymers,
constructed
from
metal
ion/cluster
nodes
functional
organic
ligands
through
bonds,
have
attracted
extensive
research
interest
during
the
past
decades.
Due
to
unique
features
diverse
compositions,
facile
synthesis,
easy
surface
functionalization,
high
areas,
adjustable
porosity,
tunable
biocompatibility,
MOFs
been
widely
used
in
hydrogen/methane
storage,
catalysis,
biological
imaging
sensing,
drug
delivery,
desalination,
gas
separation,
magnetic
electronic
devices,
nonlinear
optics,
water
vapor
capture,
etc.
Notably,
with
rapid
development
synthetic
methods
functionalization
strategies,
smart
MOF-based
nanocomposites
advanced
bio-related
properties
designed
fabricated
meet
growing
demands
MOF
materials
for
biomedical
applications.
This
work
outlines
synthesis
recent
advances
fields,
including
cargo
(drugs,
nucleic
acids,
proteins,
dyes)
delivery
cancer
therapy,
bioimaging,
antimicrobial,
biosensing,
biocatalysis.
The
prospects
challenges
field
also
discussed.
Advanced Materials,
Год журнала:
2020,
Номер
32(47)
Опубликована: Окт. 16, 2020
Ultrasound
(US)-triggered
sonodynamic
therapy
(SDT),
as
a
promising
noninvasive
therapeutic
modality,
has
received
ever-increasing
attention
in
recent
years.
Its
specialized
chemical
agents,
named
sonosensitizers,
are
activated
by
low-intensity
US
to
produce
lethal
reactive
oxygen
species
(ROS)
for
oncotherapy.
Compared
with
phototherapeutic
strategies,
SDT
provides
many
noteworthy
opportunities
and
benefits,
such
deeper
penetration
depth,
absence
of
phototoxicity,
fewer
side
effects.
Nevertheless,
previous
studies
have
also
demonstrated
its
intrinsic
limitations.
Thanks
the
facile
engineering
nature
nanotechnology,
numerous
novel
nanoplatforms
being
applied
this
emerging
field
tackle
these
barriers
achieve
continuous
innovations.
In
particular,
combination
other
treatment
strategies
superior
efficacy
improving
anticancer
activity
relative
that
monotherapies
alone.
Therefore,
it
is
necessary
summarize
nanomaterial-assisted
combinational
cancer
applications.
Herein,
design
principles
achieving
synergistic
effects
based
on
nanomaterial
methods
highlighted.
The
ultimate
goals
stimulate
better-quality
combined
schemes
provide
innovative
ideas
perspectives
promoting
future
transformation
clinical
application.
Theranostics,
Год журнала:
2020,
Номер
10(14), С. 6278 - 6309
Опубликована: Янв. 1, 2020
Multifunctional
magnetic
nanoparticles
and
derivative
nanocomposites
have
aroused
great
concern
for
multimode
imaging
cancer
synergistic
therapies
in
recent
years.Among
the
rest,
functional
iron
oxide
(Fe3O4
NPs)
shown
potential
as
an
advanced
platform
because
of
their
inherent
resonance
(MRI),
biocatalytic
activity
(nanozyme),
hyperthermia
treatment
(MHT),
photo-responsive
therapy
drug
delivery
chemotherapy
gene
therapy.Magnetic
Fe3O4
NPs
can
be
synthesized
through
several
methods
easily
surface
modified
with
biocompatible
materials
or
active
targeting
moieties.The
MRI
capacity
could
appropriately
modulated
to
induce
response
between
T1
T2
modes
by
controlling
size
distribution
NPs.Besides,
small-size
are
also
desired
due
enhanced
permeation
retention
(EPR)
effect,
thus
therapeutic
efficiency
NP-based
platforms
further
improved.Here,
we
firstly
retrospect
typical
synthesis
modification
NPs.Then,
latest
biomedical
application
including
responsive
MRI,
multimodal
imaging,
nanozyme,
MHT,
delivery,
mechanism
corresponding
treatments
cooperation
therapeutics
multifunctional
explained.Finally,
outline
a
brief
discussion
perspective
on
possibility
clinical
translations
these
nanomaterials.This
review
would
provide
comprehensive
reference
readers
understand
diagnosis
treatment.
ACS Nano,
Год журнала:
2021,
Номер
15(4), С. 6147 - 6191
Опубликована: Март 19, 2021
Janus
nanoparticles
(JNPs)
refer
to
the
integration
of
two
or
more
chemically
discrepant
composites
into
one
structure
system.
Studies
JNPs
have
been
significant
interest
due
their
interesting
characteristics
stemming
from
asymmetric
structures,
which
can
integrate
different
functional
properties
and
perform
synergetic
functions
simultaneously.
Herein,
we
present
recent
progress
particles,
comprehensively
detailing
fabrication
strategies
applications.
First,
classification
is
divided
three
blocks,
consisting
polymeric
composites,
inorganic
hybrid
polymeric/inorganic
composites.
Then,
are
alternately
summarized,
examining
self-assembly
strategy,
phase
separation
seed-mediated
polymerization,
microfluidic
preparation
nucleation
growth
methods,
masking
methods.
Finally,
various
intriguing
applications
presented,
including
solid
surfactants
agents,
micro/nanomotors,
biomedical
such
as
biosensing,
controlled
drug
delivery,
bioimaging,
cancer
therapy,
combined
theranostics.
Furthermore,
challenges
future
works
in
this
field
provided.
Journal of the American Chemical Society,
Год журнала:
2019,
Номер
141(32), С. 12475 - 12480
Опубликована: Июль 27, 2019
Tissue
is
translucent
to
shortwave
infrared
(SWIR)
light,
rendering
optical
imaging
superior
in
this
region.
However,
the
widespread
use
of
SWIR
has
been
limited,
part,
by
lack
bright,
biocompatible
contrast
agents
that
absorb
and
emit
light
above
1000
nm.
J-Aggregation
offers
a
means
transform
stable,
near-infrared
(NIR)
fluorophores
into
red-shifted
agents.
Here
we
demonstrate
J-aggregates
NIR
fluorophore
IR-140
can
be
prepared
inside
hollow
mesoporous
silica
nanoparticles
(HMSNs)
result
nanomaterials
light.
The
PEGylated
HMSNs
are
stable
for
multiple
weeks
buffer
enable
high
resolution
vivo
with
980
nm
excitation.
Nano Today,
Год журнала:
2021,
Номер
37, С. 101078 - 101078
Опубликована: Янв. 20, 2021
The
constantly
increasing
global
food
demand
galvanizes
innovative
agricultural
actions
aimed
to
transcend
current
production
levels.
predicted
near-future
security
scenario
is
alarming,
requiring
beyond
traditional
practices.
Following
the
success
of
nanotechnologies
in
pharma
and
health
sciences,
nano-enabled
agriculture
expected
increase
crop
yields
limit
losses
pathogens,
pests
other
threats.
Associated
efforts
are
enabled
by
real-time
sensing
controlled
delivery,
latter
which
considers
cargos
designed
for
targeted
release,
especially
if
triggered
on
demand.
In
this
review,
we
introduce
recent
breakthroughs
these
areas,
including
pesticide
delivery
as
well
genetic
modification
engineering
nanoparticles
application
living
materials.
We
offer
a
critical
discussion
physico-chemistry
adhesion
vegetal
tissue,
their
uptake
translocation
within
plants.
