Tailor made magnetic nanolights: fabrication to cancer theranostics applications

Nanoscale Advances, Год журнала: 2021, Номер 3(24), С. 6762 - 6796

Опубликована: Янв. 1, 2021

Nanoparticles having magnetic and fluorescent properties could be considered as a gift to materials scientists due their unique magneto-optical qualities. Multiple component particles can overcome challenges related with single unveil bifunctional/multifunctional features that enlarge applications in diagnostic imaging agents therapeutic delivery vehicles. Bifunctional nanoparticles have both luminescent are termed nanolights. Herein, we present recent progress of magneto-fluorescent (quantum dots based nanoparticles, Janus particles, heterocrystalline materials), comprehensively describing fabrication strategies, types, biomedical applications. In this review, our aim is not only encompass the preparation strategies these special types nanomaterials but also extensive bioimaging techniques, cancer therapy (targeted hyperthermic), sustained release active (drugs, proteins, antibodies, hormones, enzymes, growth factors).

Язык: Английский

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Lighting up Micro-/Nanorobots with Fluorescence

Chemical Reviews, Год журнала: 2022, Номер 123(7), С. 3944 - 3975

Опубликована: Сен. 15, 2022

Micro-/nanorobots (MNRs) can be autonomously propelled on demand in complex biological environments and thus may bring revolutionary changes to biomedicines. Fluorescence has been widely used real-time imaging, chemo-/biosensing, photo-(chemo-) therapy. The integration of MNRs with fluorescence generates fluorescent unique advantages optical trackability, on-the-fly environmental sensitivity, targeting chemo-/photon-induced cytotoxicity. This review provides an up-to-date overview MNRs. After the highlighted elucidation about various propulsion mechanisms introductory information emphasis materials, we systematically illustrate design preparation strategies integrate substances their biomedical applications imaging-guided drug delivery, intelligent sensing In end, summarize main challenges provide outlook future directions work is expected attract inspire researchers from different communities advance creation practical application a broad horizon.

Язык: Английский

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Multifunctional Janus Nanoplatform for Efficiently Synergistic Theranostics of Rheumatoid Arthritis

ACS Nano, Год журнала: 2023, Номер 17(9), С. 8167 - 8182

Опубликована: Апрель 21, 2023

Progress has been made in the application of nanomedicine rheumatoid arthritis (RA) treatment. However, whole process monitoring and treatment RA remains a formidable challenge due to complexity chronic autoimmune disease. In this study, we develop Janus nanoplatform (denoted as Janus-CPS) composed CeO2–Pt nanozyme subunit on one side periodic mesoporous organosilica (PMO) another for simultaneous early diagnosis synergistic therapy RA. The nanostructure, which enables more active sites be exposed, enhances reactive oxygen species scavenging capability compared their core–shell counterpart. Furthermore, micheliolide (MCL), an extracted compound from natural plants with anti-osteoclastogenesis effects, is loaded into mesopores PMO synergize anti-inflammation effect nanozymes efficient treatment, demonstrated by vitro cellular experiments vivo collagen-induced (CIA) model. addition, taking advantage second near-infrared window (NIR-II) fluorescent imaging, indocyanine green (ICG)-loaded Janus-CPS exhibits desirable effectiveness detecting lesions at very stage. It anticipated that such may offer alternative strategy functional integration versatile theranostics.

Язык: Английский

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Designing of anisotropic gradient surfaces for directional liquid transport: Fundamentals, construction, and applications

The Innovation, Год журнала: 2023, Номер 4(6), С. 100508 - 100508

Опубликована: Сен. 9, 2023

Язык: Английский

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Robust and Multifunctional Nanoparticles Assembled from Natural Polyphenols and Metformin for Efficient Spinal Cord Regeneration

ACS Nano, Год журнала: 2023, Номер 17(18), С. 18562 - 18575

Опубликована: Сен. 14, 2023

The treatment of spinal cord injury (SCI) remains unsatisfactory owing to the complex pathophysiological microenvironments at site and limited regenerative potential central nervous system. Metformin has been proven in clinical animal experiments repair damaged structures functions by promoting endogenous neurogenesis. However, early stage acute SCI, adverse microenvironment sites, such as reactive oxygen species inflammatory factor storm, can prevent activation neural stem cells (NSCs) differentiation NSCs into neurons, decreasing whole effect. To address those issues, a series robust multifunctional natural polyphenol-metformin nanoparticles (polyphenol-Met NPs) were fabricated with pH-responsiveness excellent antioxidative capacities. resulting NPs possessed several favorable advantages: First, composed active ingredients different biological properties, without need for carriers; second, feature could allow targeted drug delivery injured site; more importantly, enabled drugs performances exhibit strong synergistic effects. results demonstrated that improved polyphenols boosted activated neurons oligodendrocytes, which efficiently nerve enhance functional recovery SCI rats. This work highlighted design fabrication via efficient microenvironmental regulation activation.

Язык: Английский

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Spatially Asymmetric Nanoparticles for Boosting Ferroptosis in Tumor Therapy

Nano Letters, Год журнала: 2024, Номер 24(4), С. 1284 - 1293

Опубликована: Янв. 17, 2024

Despite its effectiveness in eliminating cancer cells, ferroptosis is hindered by the high natural antioxidant glutathione (GSH) levels tumor microenvironment. Herein, we developed a spatially asymmetric nanoparticle, Fe3O4@DMS&PDA@MnO2-SRF, for enhanced ferroptosis. It consists of two subunits: Fe3O4 nanoparticles coated with dendritic mesoporous silica (DMS) and PDA@MnO2 (PDA: polydopamine) loaded sorafenib (SRF). The spatial isolation Fe3O4@DMS PDA@MnO2-SRF subunits enhances synergistic effect between GSH-scavengers ferroptosis-related components. First, increased exposure subunit Fenton reaction, leading to production reactive oxygen species. Furthermore, effectively depletes GSH, thereby inducing inactivation glutathione-dependent peroxidases 4. Moreover, SRF blocks Xc– transport augmenting GSH depletion capabilities. dual Fe3O4@DMS&PDA@MnO2-SRF significantly weakens antioxidative system, boosting chemodynamic performance cells.

Язык: Английский

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Upconverting/magnetic Janus-like nanoparticles integrated into spiropyran micelle-like nanocarriers for NIR light- and pH- responsive drug delivery, photothermal therapy and biomedical imaging

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 249, С. 114501 - 114501

Опубликована: Янв. 7, 2025

The integration of multiple functionalities into single theranostic platforms offers new opportunities for personalized and minimally invasive clinical interventions, positioning these materials as highly promising tools in modern medicine. Thereby, magneto-luminescent Janus-like nanoparticles (JNPs) were developed herein, encapsulated near-infrared (NIR) light- pH- responsive micelle-like aggregates (Mic) simultaneous magnetic targeting, biomedical imaging, photothermal therapy, NIR-light activated drug delivery. JNPs consisted NaYF4:Yb,Tm upconverting (UCNPs) on which a well-differentiated magnetite structure (MNPs) grew epitaxially. together with doxorubicin (Dox) formed the stimuli-responsive Poly(NIPAM-co-Spiropyran) copolymer, responds to UV light, temperature changes, pH variations, so form JNP-Dox@Mic nanocarrier. Based physicochemical characterizations, mechanism NIR-activated release Dox from is suggested: i) activation emissions 975 nm ii) energy transfer material's lattice via nonradiative relaxation, inducing local increase, iii) resonance (RET) UV-emission bands aggregates, iv) reversible isomerization hydrophobic Spiropyran (SP) moiety hydrophilic zwitterionic merocyanine (MC) form, leading Furthermore, strong light-to-heat conversion ability was demonstrated through thermal imaging analysis, reaching temperatures up 108 °C upon irradiation 60 seconds. efficacy nanocomposites NIR-light-induced controlled using electrophoretic separations tested against MCF-7 breast cancer cells. While non-irradiated samples innocuous 200 μg.mL-1, light 5 minutes reduced cell viability 26 %. These findings highlight effective synergy between resulting versatile heterostructures that could be evaluated multimodal therapy strategies.

Язык: Английский

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Preparation and application of Janus nanoparticles: Recent development and prospects

Coordination Chemistry Reviews, Год журнала: 2021, Номер 454, С. 214318 - 214318

Опубликована: Ноя. 27, 2021

Язык: Английский

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Multicomponent magnetic nanoparticle engineering: the role of structure-property relationship in advanced applications

Materials Today Chemistry, Год журнала: 2022, Номер 26, С. 101220 - 101220

Опубликована: Окт. 22, 2022

Combining magnetic nanomaterials with materials of other classes can produce multicomponent nanoparticles an entire ensemble new structures and unique, enhanced, synergetic, and/or complementary functionalities. Here we discuss the most recent developments in synthesis nanoparticles, describe resulting their novel properties, explore application a variety fields, including multimodal imaging, nanomedicine, sensing, surface-enhanced Raman scattering, heterogeneous catalysis. The current synthetic methods (usually bottom-up approaches) number tailored morphologies ([email protected], yolk-shell, core-satellite, Janus, nanochains, anisotropic, etc.), making them invaluable for applications biology, medicine, chemistry, physics, engineering. But like any technology, need to be optimized simple, scalable, as environmentally friendly possible before they widely adopted. In particular, use life cycle assessment (LCA) guide future works toward environmental sustainability is highlighted. Overall, this review not only presents critical timely summary state-of-the-art burgeoning field both fundamental applied nanotechnology, but also addresses challenges associated understanding particular structure-property relationships nanoparticles.

Язык: Английский

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A Novel Electrochemiluminescence Janus Emitter for Dual‐Mode Biosensing

Advanced Functional Materials, Год журнала: 2022, Номер 32(24)

Опубликована: Март 13, 2022

Abstract A novel electrochemiluminescence (ECL) Janus emitter realizes dual‐mode biosensing for multiple disease‐related biomarkers from cells. Each consists of ruthenium (II) complex and luminol polymer doped hemispheres that are spatially separated but function simultaneously, generating intense dual‐ECL emissions. This design effectively eliminates optical electrochemical interferences between different ECL mono‐luminophores in comparison with the homogenous nanostructures, thereby improving efficiency detection sensitivity. Accordingly, emitters provide a proof concept construction ratiometric sensing H 2 O . Furthermore, this enables simultaneous identification quantification intracellular cancer‐related dual microRNAs. work not only inspires development emitters, also highlights their potential bioanalysis clinical diagnosis future.

Язык: Английский

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