ACS Nano,
Год журнала:
2022,
Номер
16(9), С. 13468 - 13491
Опубликована: Сен. 8, 2022
Naturally
derived
cellulose
nanomaterials
(CNMs)
with
desirable
physicochemical
properties
have
drawn
tremendous
attention
for
their
versatile
applications
in
a
broad
range
of
fields.
More
recently,
Janus
amphiphilic
nanomaterial
particles
asymmetric
structures
(i.e.,
reducing
and
nonreducing
ends
crystalline
amorphous
domains)
been
the
spotlight,
offering
rich
sophisticated
toolbox
nanomaterials.
With
careful
surface
interfacial
engineering,
CNM
demonstrated
great
potential
as
modifiers,
emulsifiers,
stabilizers,
compatibilizers,
dispersants
emulsions,
nanocomposites,
suspensions.
offer
fascinating
opportunity
scaling
up
production
self-standing
membranes.
Nevertheless,
most
membranes
to
date
are
constructed
by
fabrication
or
modification
without
considering
traits
particles.
future
research
should
focus
on
self-assembly
into
bulk
enable
more
straightforward
sustainable
approaches
This
review
explores
fabrication,
structure–property
relationship,
configuration
mechanisms
highlighted
liquid,
thermal,
light
management.
also
highlights
significant
advances
perspectives
construction
application
Chemical Reviews,
Год журнала:
2022,
Номер
123(7), С. 3944 - 3975
Опубликована: Сен. 15, 2022
Micro-/nanorobots
(MNRs)
can
be
autonomously
propelled
on
demand
in
complex
biological
environments
and
thus
may
bring
revolutionary
changes
to
biomedicines.
Fluorescence
has
been
widely
used
real-time
imaging,
chemo-/biosensing,
photo-(chemo-)
therapy.
The
integration
of
MNRs
with
fluorescence
generates
fluorescent
unique
advantages
optical
trackability,
on-the-fly
environmental
sensitivity,
targeting
chemo-/photon-induced
cytotoxicity.
This
review
provides
an
up-to-date
overview
MNRs.
After
the
highlighted
elucidation
about
various
propulsion
mechanisms
introductory
information
emphasis
materials,
we
systematically
illustrate
design
preparation
strategies
integrate
substances
their
biomedical
applications
imaging-guided
drug
delivery,
intelligent
sensing
In
end,
summarize
main
challenges
provide
outlook
future
directions
work
is
expected
attract
inspire
researchers
from
different
communities
advance
creation
practical
application
a
broad
horizon.
ACS Nano,
Год журнала:
2023,
Номер
17(9), С. 8167 - 8182
Опубликована: Апрель 21, 2023
Progress
has
been
made
in
the
application
of
nanomedicine
rheumatoid
arthritis
(RA)
treatment.
However,
whole
process
monitoring
and
treatment
RA
remains
a
formidable
challenge
due
to
complexity
chronic
autoimmune
disease.
In
this
study,
we
develop
Janus
nanoplatform
(denoted
as
Janus-CPS)
composed
CeO2–Pt
nanozyme
subunit
on
one
side
periodic
mesoporous
organosilica
(PMO)
another
for
simultaneous
early
diagnosis
synergistic
therapy
RA.
The
nanostructure,
which
enables
more
active
sites
be
exposed,
enhances
reactive
oxygen
species
scavenging
capability
compared
their
core–shell
counterpart.
Furthermore,
micheliolide
(MCL),
an
extracted
compound
from
natural
plants
with
anti-osteoclastogenesis
effects,
is
loaded
into
mesopores
PMO
synergize
anti-inflammation
effect
nanozymes
efficient
treatment,
demonstrated
by
vitro
cellular
experiments
vivo
collagen-induced
(CIA)
model.
addition,
taking
advantage
second
near-infrared
window
(NIR-II)
fluorescent
imaging,
indocyanine
green
(ICG)-loaded
Janus-CPS
exhibits
desirable
effectiveness
detecting
lesions
at
very
stage.
It
anticipated
that
such
may
offer
alternative
strategy
functional
integration
versatile
theranostics.
ACS Nano,
Год журнала:
2023,
Номер
17(18), С. 18562 - 18575
Опубликована: Сен. 14, 2023
The
treatment
of
spinal
cord
injury
(SCI)
remains
unsatisfactory
owing
to
the
complex
pathophysiological
microenvironments
at
site
and
limited
regenerative
potential
central
nervous
system.
Metformin
has
been
proven
in
clinical
animal
experiments
repair
damaged
structures
functions
by
promoting
endogenous
neurogenesis.
However,
early
stage
acute
SCI,
adverse
microenvironment
sites,
such
as
reactive
oxygen
species
inflammatory
factor
storm,
can
prevent
activation
neural
stem
cells
(NSCs)
differentiation
NSCs
into
neurons,
decreasing
whole
effect.
To
address
those
issues,
a
series
robust
multifunctional
natural
polyphenol-metformin
nanoparticles
(polyphenol-Met
NPs)
were
fabricated
with
pH-responsiveness
excellent
antioxidative
capacities.
resulting
NPs
possessed
several
favorable
advantages:
First,
composed
active
ingredients
different
biological
properties,
without
need
for
carriers;
second,
feature
could
allow
targeted
drug
delivery
injured
site;
more
importantly,
enabled
drugs
performances
exhibit
strong
synergistic
effects.
results
demonstrated
that
improved
polyphenols
boosted
activated
neurons
oligodendrocytes,
which
efficiently
nerve
enhance
functional
recovery
SCI
rats.
This
work
highlighted
design
fabrication
via
efficient
microenvironmental
regulation
activation.
Nano Letters,
Год журнала:
2024,
Номер
24(4), С. 1284 - 1293
Опубликована: Янв. 17, 2024
Despite
its
effectiveness
in
eliminating
cancer
cells,
ferroptosis
is
hindered
by
the
high
natural
antioxidant
glutathione
(GSH)
levels
tumor
microenvironment.
Herein,
we
developed
a
spatially
asymmetric
nanoparticle,
Fe3O4@DMS&PDA@MnO2-SRF,
for
enhanced
ferroptosis.
It
consists
of
two
subunits:
Fe3O4
nanoparticles
coated
with
dendritic
mesoporous
silica
(DMS)
and
PDA@MnO2
(PDA:
polydopamine)
loaded
sorafenib
(SRF).
The
spatial
isolation
Fe3O4@DMS
PDA@MnO2-SRF
subunits
enhances
synergistic
effect
between
GSH-scavengers
ferroptosis-related
components.
First,
increased
exposure
subunit
Fenton
reaction,
leading
to
production
reactive
oxygen
species.
Furthermore,
effectively
depletes
GSH,
thereby
inducing
inactivation
glutathione-dependent
peroxidases
4.
Moreover,
SRF
blocks
Xc–
transport
augmenting
GSH
depletion
capabilities.
dual
Fe3O4@DMS&PDA@MnO2-SRF
significantly
weakens
antioxidative
system,
boosting
chemodynamic
performance
cells.
Nanoscale Advances,
Год журнала:
2021,
Номер
3(24), С. 6762 - 6796
Опубликована: Янв. 1, 2021
Nanoparticles
having
magnetic
and
fluorescent
properties
could
be
considered
as
a
gift
to
materials
scientists
due
their
unique
magneto-optical
qualities.
Multiple
component
particles
can
overcome
challenges
related
with
single
unveil
bifunctional/multifunctional
features
that
enlarge
applications
in
diagnostic
imaging
agents
therapeutic
delivery
vehicles.
Bifunctional
nanoparticles
have
both
luminescent
are
termed
nanolights.
Herein,
we
present
recent
progress
of
magneto-fluorescent
(quantum
dots
based
nanoparticles,
Janus
particles,
heterocrystalline
materials),
comprehensively
describing
fabrication
strategies,
types,
biomedical
applications.
In
this
review,
our
aim
is
not
only
encompass
the
preparation
strategies
these
special
types
nanomaterials
but
also
extensive
bioimaging
techniques,
cancer
therapy
(targeted
hyperthermic),
sustained
release
active
(drugs,
proteins,
antibodies,
hormones,
enzymes,
growth
factors).
Materials Today Chemistry,
Год журнала:
2022,
Номер
26, С. 101220 - 101220
Опубликована: Окт. 22, 2022
Combining
magnetic
nanomaterials
with
materials
of
other
classes
can
produce
multicomponent
nanoparticles
an
entire
ensemble
new
structures
and
unique,
enhanced,
synergetic,
and/or
complementary
functionalities.
Here
we
discuss
the
most
recent
developments
in
synthesis
nanoparticles,
describe
resulting
their
novel
properties,
explore
application
a
variety
fields,
including
multimodal
imaging,
nanomedicine,
sensing,
surface-enhanced
Raman
scattering,
heterogeneous
catalysis.
The
current
synthetic
methods
(usually
bottom-up
approaches)
number
tailored
morphologies
([email
protected],
yolk-shell,
core-satellite,
Janus,
nanochains,
anisotropic,
etc.),
making
them
invaluable
for
applications
biology,
medicine,
chemistry,
physics,
engineering.
But
like
any
technology,
need
to
be
optimized
simple,
scalable,
as
environmentally
friendly
possible
before
they
widely
adopted.
In
particular,
use
life
cycle
assessment
(LCA)
guide
future
works
toward
environmental
sustainability
is
highlighted.
Overall,
this
review
not
only
presents
critical
timely
summary
state-of-the-art
burgeoning
field
both
fundamental
applied
nanotechnology,
but
also
addresses
challenges
associated
understanding
particular
structure-property
relationships
nanoparticles.
Advanced Functional Materials,
Год журнала:
2022,
Номер
32(24)
Опубликована: Март 13, 2022
Abstract
A
novel
electrochemiluminescence
(ECL)
Janus
emitter
realizes
dual‐mode
biosensing
for
multiple
disease‐related
biomarkers
from
cells.
Each
consists
of
ruthenium
(II)
complex
and
luminol
polymer
doped
hemispheres
that
are
spatially
separated
but
function
simultaneously,
generating
intense
dual‐ECL
emissions.
This
design
effectively
eliminates
optical
electrochemical
interferences
between
different
ECL
mono‐luminophores
in
comparison
with
the
homogenous
nanostructures,
thereby
improving
efficiency
detection
sensitivity.
Accordingly,
emitters
provide
a
proof
concept
construction
ratiometric
sensing
H
2
O
.
Furthermore,
this
enables
simultaneous
identification
quantification
intracellular
cancer‐related
dual
microRNAs.
work
not
only
inspires
development
emitters,
also
highlights
their
potential
bioanalysis
clinical
diagnosis
future.
Oral
drug
delivery
systems
have
great
potential
to
treat
colorectal
cancer
(CRC).
However,
the
efficiency
is
restricted
by
limited
CRC-related
intestine
positioning
and
dense
mucus
barrier.
Here,
we
present
a
biological
chemotaxis-guided
self-thermophoretic
nanoplatform
that
facilitates
precise
intestinal
autonomous
penetration.
The
introduces
asymmetric
platinum-sprayed
mesoporous
silica
achieve
movement
in
mucus.
Furthermore,
inspired
intense
interaction
between
pathogenic
microbes
CRC,
camouflaged
Staphylococcus
aureus
membrane
precisely
anchor
intestine.
Owing
4.3-fold
higher
chemotactic
anchoring
of
14.6-fold
penetration
performance,
vastly
improves
oral
bioavailability
cisplatin,
leading
tumor
inhibition
rate
99.1%
on
orthotopic
CRC-bearing
mice.
Together,
exquisitely
designed
overcome
multiple
physiological
barriers
provides
new
horizon
for
development
systems.
