Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
The
western
mosquitofish
(Gambusia
affinis
(G.
affinis))
is
often
the
only
fish
that
survives
in
various
selenium-contaminated
aquatic
environments.
However,
mechanisms
of
its
survival
such
environments
remain
seldom
explored.
In
this
study,
acute
toxicity
selenomethionine
(Se-Met)
a
variety
species
(four
oviparous
and
four
ovoviviparous
species)
was
evaluated,
followed
by
chronic
effects
Se-Met
on
G.
zebrafish
(Danio
rerio
(D.
rerio)),
focusing
Se
accumulation
gonads
offspring,
reproductive
biology,
offspring
development.
Our
results
showed
LC50-96h
largest
among
eight
fish,
confirming
elevated
resistance
to
Se.
Meanwhile,
transcripts
genes
related
selenoproteins
sulfoproteins
opposite
responses
between
D.
exposure,
along
with
altered
levels
total
but
not
fish.
exposures
gonads,
gonadal
development
embryonic
early
larval
development,
efflux
embryos
larvae
were
apparently
different
rerio.
Finally,
differentially
expressed
(particularly
antioxidant
inflammation)
mostly
stimulated
inhibited
This
study
has
demonstrated
capacity
metabolism
physiology
can
help
partially
explain
Se-contaminated
ecosystems.
Trends in Environmental Analytical Chemistry,
Год журнала:
2022,
Номер
34, С. e00161 - e00161
Опубликована: Апрель 11, 2022
Metabolomics
is
a
discipline
aiming
to
characterize
the
presence
of
metabolites
in
biological
matrices
under
specific
conditions.
In
recent
years,
metabolomics
has
increasingly
been
used
environmental
research
explore
metabolic
changes
humans
and
organisms
diverse
exposures,
mainly
chemical
pollutants.
Hence,
become
key
tool
exposome
studies,
effects
at
molecular
level
exerted
by
xenobiotics.
To
understand
mechanisms
triggered
compounds,
combination
with
information
about
xenobiotics
samples
(xenometabolome),
other
obtained
from
omics
technologies
(e.g.
transcriptomics,
proteomics)
crucial,
both
adverse
outcome
pathways
(AOPs)
development.
This
review
aims
describe
main
applications
assessment
induced
pollutants
on
ecosystems
human
health,
studies
laboratory-controlled
assays.
Different
analytical
aspects
challenges
are
presented
discussed.
Finally,
different
opportunities
current
situation
as
safety
for
regulatory
reviewed.
Metabolites,
Год журнала:
2024,
Номер
14(2), С. 98 - 98
Опубликована: Янв. 31, 2024
Metabolomics
is
emerging
as
a
powerful
systems
biology
approach
for
improving
preclinical
drug
safety
assessment.
This
review
discusses
current
applications
and
future
trends
of
metabolomics
in
toxicology
development.
can
elucidate
adverse
outcome
pathways
by
detecting
endogenous
biochemical
alterations
underlying
toxicity
mechanisms.
Furthermore,
enables
better
characterization
human
environmental
exposures
their
influence
on
disease
pathogenesis.
approaches
are
being
increasingly
incorporated
into
studies
pharmacology
evaluations
to
gain
mechanistic
insights
identify
early
biomarkers
toxicity.
However,
realizing
the
full
potential
regulatory
decision
making
requires
robust
demonstration
reliability
through
quality
assurance
practices,
reference
materials,
interlaboratory
studies.
Overall,
shows
great
promise
strengthening
understanding
toxicity,
enhancing
routine
screening,
transforming
exposure
risk
assessment
paradigms.
Integration
with
computational,
vitro,
personalized
medicine
innovations
will
shape
predictive
toxicology.
Environmental Science & Technology,
Год журнала:
2022,
Номер
56(12), С. 8020 - 8033
Опубликована: Июнь 2, 2022
Exposure
to
excessive
manganese
(Mn)
is
toxic
humans
and
animals.
However,
the
effects
mechanisms
of
Mn
influencing
vertebrates
have
been
highly
overlooked.
In
present
study,
dietary
overload
significantly
increased
hepatic
lipid
contents,
decreased
superoxide
dismutase
2
(Sod2)
activity,
Sod2
acetylation
level,
induced
mitochondrial
dysfunction;
dysfunction
through
Mtf1/sirtuin
3
(Sirt3)-mediated
at
sites
K55
K70.
Meanwhile,
oxidative
stress
was
involved
in
Mn-induced
lipotoxicity.
Mechanistically,
lipotoxicity
via
stress-induced
Hsf1
nucleus
translocation
its
DNA
binding
capacity
regions
a
peroxisome
proliferator-activated
receptor
g
(pparg)
promoter,
which
turn
transcription
lipogenic-related
target
genes.
For
first
time,
our
study
demonstrated
that
stress-dependent
Hsf1/Pparg
pathway
Mtf1/sirt3-mediated
participated
dysfunction.
Considering
metabolism
are
widely
used
as
biomarkers
for
environmental
assessments
pollutants,
provided
innovative
important
insights
into
toxicological
evaluation
aquatic
environments.
Chemosphere,
Год журнала:
2024,
Номер
364, С. 143214 - 143214
Опубликована: Авг. 29, 2024
Anthropogenic
activities
have
led
to
increased
levels
of
contaminants
that
pose
significant
threats
aquatic
organisms,
particularly
fishes.
One
such
contaminant
is
Selenium
(Se),
a
metalloid
which
released
by
various
industrial
including
mining
and
fossil
fuel
combustion.
crucial
for
physiological
functions,
however
it
can
bioaccumulate
become
toxic
at
elevated
concentrations.
Given
fishes
are
key
predators
in
ecosystems
major
protein
source
humans,
Se
accumulation
raises
considerable
ecological
food
safety
concerns.
induces
toxicity
the
cellular
level
disrupting
balance
between
reactive
oxygen
species
(ROS)
production
antioxidant
capacity
leading
oxidative
damage.
Chronic
exposure
impairs
wide
range
critical
functions
metabolism,
growth
reproduction.
also
potent
teratogen
types
adverse
developmental
effects
fishes,
mainly
due
its
maternal
transfer
eggs.
Moreover,
persist
across
generations.
Furthermore,
Se-induced
stress
brain
driver
neurotoxicity,
leads
impairment
several
ecologically
important
behaviours
cognition
memory
social
preference
interactions,
anxiety
response.
Our
review
provides
an
up-to-date
in-depth
analysis
while
identifying
knowledge
gaps
need
be
addressed
future
research
greater
insights
into
impact
ecosystems.
Antioxidants,
Год журнала:
2025,
Номер
14(4), С. 408 - 408
Опубликована: Март 28, 2025
Hypertension
(HTN)
is
a
complex
disease
with
significant
global
health
implications,
driven
by
neural
and
oxidative
mechanisms.
Reactive
oxygen
species
(ROS),
once
considered
mere
metabolic
byproducts,
are
now
recognized
as
one
of
the
key
contributors
to
dysfunction
autonomic
nerve
system,
which
involves
onset
progression
HTN.
This
review
highlights
dynamic
roles
ROS
in
neuronal
signaling,
subcellular
compartmentalization,
brain–immune
interactions,
focusing
on
their
impacts
synaptic
remodeling,
neuroinflammation,
epigenetic
modifications
within
regions
such
paraventricular
nucleus
rostral
ventrolateral
medulla.
We
discuss
novel
sources,
including
microglia-derived
endoplasmic
reticulum
stress-related
ROS,
contributions
Subcellular
dynamics,
signaling
at
mitochondria-associated
membranes
microdomains,
explored
activators
sympathetic
system.
Emerging
evidence
has
linked
regulation,
histone
non-coding
RNA
expression,
sex-specific
differences
offering
insights
for
development
personalized
therapies.
Innovative
therapeutic
strategies
targeting
involve
precision
delivery
systems,
modulators,
circadian-optimized
antioxidants.
propose
several
priorities
future
research,
real-time
imaging
brain
translating
preclinical
findings
into
clinical
applications,
leveraging
medicine
develop
tailored
interventions
based
activity
genetic
predisposition.
Through
emphasizing
spatial
temporal
complexity
HTN,
this
identifies
opportunities
establishes
foundation
targeted
treatments
address
challenge.
