Why Western Mosquitofish (Gambusia affinis) Is Tolerant to Se Contamination: Complex Mechanistic Explanations DOI

Xinrong Wei,

Xiao Li,

Wenji Zhou

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

The western mosquitofish (Gambusia affinis (G. affinis)) is often the only fish that survives in various selenium-contaminated aquatic environments. However, mechanisms of its survival such environments remain seldom explored. In this study, acute toxicity selenomethionine (Se-Met) a variety species (four oviparous and four ovoviviparous species) was evaluated, followed by chronic effects Se-Met on G. zebrafish (Danio rerio (D. rerio)), focusing Se accumulation gonads offspring, reproductive biology, offspring development. Our results showed LC50-96h largest among eight fish, confirming elevated resistance to Se. Meanwhile, transcripts genes related selenoproteins sulfoproteins opposite responses between D. exposure, along with altered levels total but not fish. exposures gonads, gonadal development embryonic early larval development, efflux embryos larvae were apparently different rerio. Finally, differentially expressed (particularly antioxidant inflammation) mostly stimulated inhibited This study has demonstrated capacity metabolism physiology can help partially explain Se-contaminated ecosystems.

Язык: Английский

Multiview behavior and neurotransmitter analysis of zebrafish dyskinesia induced by 6PPD and its metabolites DOI

Jiawen Ji,

Jinze Huang,

Niannian Cao

и другие.

The Science of The Total Environment, Год журнала: 2022, Номер 838, С. 156013 - 156013

Опубликована: Май 17, 2022

Язык: Английский

Процитировано

66

Metabolomics in environmental toxicology: Applications and challenges DOI Creative Commons
Carmen Bedia

Trends in Environmental Analytical Chemistry, Год журнала: 2022, Номер 34, С. e00161 - e00161

Опубликована: Апрель 11, 2022

Metabolomics is a discipline aiming to characterize the presence of metabolites in biological matrices under specific conditions. In recent years, metabolomics has increasingly been used environmental research explore metabolic changes humans and organisms diverse exposures, mainly chemical pollutants. Hence, become key tool exposome studies, effects at molecular level exerted by xenobiotics. To understand mechanisms triggered compounds, combination with information about xenobiotics samples (xenometabolome), other obtained from omics technologies (e.g. transcriptomics, proteomics) crucial, both adverse outcome pathways (AOPs) development. This review aims describe main applications assessment induced pollutants on ecosystems human health, studies laboratory-controlled assays. Different analytical aspects challenges are presented discussed. Finally, different opportunities current situation as safety for regulatory reviewed.

Язык: Английский

Процитировано

63

Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout DOI
Xiao-Liang Liao, Zhifeng Chen, Shi-Ping Ou

и другие.

Science Bulletin, Год журнала: 2023, Номер 69(5), С. 621 - 635

Опубликована: Дек. 26, 2023

Язык: Английский

Процитировано

32

Neurotoxic effects of 2-ethylhexyl diphenyl phosphate exposure on zebrafish larvae: Insight into inflammation-driven changes in early motor behavior DOI

Anyu Ni,

Fang Lü,

M Xi

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 915, С. 170131 - 170131

Опубликована: Янв. 20, 2024

Язык: Английский

Процитировано

10

Metabolomics in Preclinical Drug Safety Assessment: Current Status and Future Trends DOI Creative Commons
Fenna C.M. Sillé, Thomas Härtung

Metabolites, Год журнала: 2024, Номер 14(2), С. 98 - 98

Опубликована: Янв. 31, 2024

Metabolomics is emerging as a powerful systems biology approach for improving preclinical drug safety assessment. This review discusses current applications and future trends of metabolomics in toxicology development. can elucidate adverse outcome pathways by detecting endogenous biochemical alterations underlying toxicity mechanisms. Furthermore, enables better characterization human environmental exposures their influence on disease pathogenesis. approaches are being increasingly incorporated into studies pharmacology evaluations to gain mechanistic insights identify early biomarkers toxicity. However, realizing the full potential regulatory decision making requires robust demonstration reliability through quality assurance practices, reference materials, interlaboratory studies. Overall, shows great promise strengthening understanding toxicity, enhancing routine screening, transforming exposure risk assessment paradigms. Integration with computational, vitro, personalized medicine innovations will shape predictive toxicology.

Язык: Английский

Процитировано

10

Sirt3-Sod2-mROS-Mediated Manganese Triggered Hepatic Mitochondrial Dysfunction and Lipotoxicity in a Freshwater Teleost DOI
Tao Zhao,

Wu-Hong Lv,

Christer Högstrand

и другие.

Environmental Science & Technology, Год журнала: 2022, Номер 56(12), С. 8020 - 8033

Опубликована: Июнь 2, 2022

Exposure to excessive manganese (Mn) is toxic humans and animals. However, the effects mechanisms of Mn influencing vertebrates have been highly overlooked. In present study, dietary overload significantly increased hepatic lipid contents, decreased superoxide dismutase 2 (Sod2) activity, Sod2 acetylation level, induced mitochondrial dysfunction; dysfunction through Mtf1/sirtuin 3 (Sirt3)-mediated at sites K55 K70. Meanwhile, oxidative stress was involved in Mn-induced lipotoxicity. Mechanistically, lipotoxicity via stress-induced Hsf1 nucleus translocation its DNA binding capacity regions a peroxisome proliferator-activated receptor g (pparg) promoter, which turn transcription lipogenic-related target genes. For first time, our study demonstrated that stress-dependent Hsf1/Pparg pathway Mtf1/sirt3-mediated participated dysfunction. Considering metabolism are widely used as biomarkers for environmental assessments pollutants, provided innovative important insights into toxicological evaluation aquatic environments.

Язык: Английский

Процитировано

34

Nano-zerovalent copper biochar composite for treating selenium oxyanions in water: synthesis, evaluation, removal mechanism, density functional theory, and molecular dynamics simulations DOI

Mahvish Abbasi,

Osama Shaheen Rizvi, Syed Zajif Hussain

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 149954 - 149954

Опубликована: Фев. 23, 2024

Язык: Английский

Процитировано

9

An azole fungicide climbazole damages the gut-brain axis in the grass carp DOI
Zhijie Lu, Wenjun Shi, Fang-Zhou Gao

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 465, С. 133463 - 133463

Опубликована: Янв. 10, 2024

Язык: Английский

Процитировано

8

Selenium toxicity in fishes: A current perspective DOI Creative Commons
Md. Helal Uddin, Jinnath Rehana Ritu, Sravan Kumar Putnala

и другие.

Chemosphere, Год журнала: 2024, Номер 364, С. 143214 - 143214

Опубликована: Авг. 29, 2024

Anthropogenic activities have led to increased levels of contaminants that pose significant threats aquatic organisms, particularly fishes. One such contaminant is Selenium (Se), a metalloid which released by various industrial including mining and fossil fuel combustion. crucial for physiological functions, however it can bioaccumulate become toxic at elevated concentrations. Given fishes are key predators in ecosystems major protein source humans, Se accumulation raises considerable ecological food safety concerns. induces toxicity the cellular level disrupting balance between reactive oxygen species (ROS) production antioxidant capacity leading oxidative damage. Chronic exposure impairs wide range critical functions metabolism, growth reproduction. also potent teratogen types adverse developmental effects fishes, mainly due its maternal transfer eggs. Moreover, persist across generations. Furthermore, Se-induced stress brain driver neurotoxicity, leads impairment several ecologically important behaviours cognition memory social preference interactions, anxiety response. Our review provides an up-to-date in-depth analysis while identifying knowledge gaps need be addressed future research greater insights into impact ecosystems.

Язык: Английский

Процитировано

7

Chemical characteristics and toxicological effects of leachates from plastics under simulated seawater and fish digest DOI

Shuqing Qiu,

Guo‐Yong Huang,

Guizhen Fang

и другие.

Water Research, Год журнала: 2021, Номер 209, С. 117892 - 117892

Опубликована: Ноя. 24, 2021

Язык: Английский

Процитировано

36