Per-
and
polyfluoroalkyl
acids
(PFAAs)
including
carboxylic
sulfonic
are
a
large
category
of
crucial
environmental
pollutants
global
concern.
Besides
known
PFAAs,
numerous
unknown
species
may
exist
in
the
environment,
urgently
needing
discovery
characterization.
This
study
implemented
nontarget
analysis
for
group
novel
PFAA
pollutants,
viz.
iodinated
PFAAs
(I-PFAAs)
wastewater
by
liquid
chromatography-high-resolution
mass
spectrometry
combination
with
an
iodine-specific
data-processing
algorithm.
The
algorithm
took
into
account
diagnostic
fragment
iodine
ion
(I–)
together
carbon
sulfur
isotopologue
distributions.
In
total,
21
I-PFAA
formulas
involving
24
congeners
were
identified.
Semiquantification
was
conducted,
total
concentrations
I-PFAAs
1.9-311.9
ng/mL,
indicating
non-negligible
pollution
wastewater.
determined
along
predicted
behaviors
toxicities
demonstrate
that
merit
further
in-depth
investigation.
analytical
method
instrumental
can
be
extended
to
screening
identification
other
matrices.
Furthermore,
results
first
time
provide
cognition
on
occurrence
features
status
environment.
Environmental Science & Technology,
Год журнала:
2023,
Номер
57(3), С. 1378 - 1390
Опубликована: Янв. 9, 2023
Per-
and
polyfluoroalkyl
acids
(PFAAs)
including
carboxylic
sulfonic
are
a
large
category
of
crucial
environmental
pollutants
global
concern.
Besides
known
PFAAs,
numerous
unknown
species
may
exist
in
the
environment,
urgently
needing
discovery
characterization.
This
study
implemented
nontarget
analysis
for
group
novel
PFAA
pollutants,
viz.,
iodinated
PFAAs
(I-PFAAs)
wastewater
from
fluorochemical
manufacturing
park
by
liquid
chromatography–high-resolution
mass
spectrometry
combination
with
an
iodine-specific
data-processing
algorithm.
The
algorithm
took
into
account
diagnostic
fragment
iodine
ion
(I–)
together
carbon
sulfur
isotopologue
distributions.
In
total,
18
I-PFAA
formulas
involving
21
congeners
were
identified.
Semiquantification
was
conducted,
total
concentrations
I-PFAAs
1.9–274.7
μg/L,
indicating
severe
pollution
wastewater.
determined
along
predicted
behaviors
toxicities
demonstrate
that
merit
further
in-depth
investigation.
analytical
method
instrumental
can
be
extended
to
screening
identification
other
matrices.
Furthermore,
results
first
time
provide
recognition
on
occurrence,
distribution
features,
status
environment.
Pharmacological Research,
Год журнала:
2024,
Номер
203, С. 107162 - 107162
Опубликована: Март 28, 2024
In
American
men,
the
incidence
of
prostate
cancer
(PC)
is
highest
among
all
types
cancer,
making
it
second
leading
cause
mortality
associated
with
cancer.
For
advanced
or
metastatic
PC,
antiandrogen
therapies
are
standard
treatment
options.
The
administration
these
treatments
unfortunately
carries
potential
risk
inducing
neuroendocrine
(NEPC).
Neuroendocrine
differentiation
(NED)
serves
as
a
crucial
indicator
development,
encompassing
various
factors
such
phosphatidylinositol
3-kinase/protein
kinase
B/mammalian
target
rapamycin
(PI3K/AKT/mTOR),
Yes-associated
protein
1
(YAP1),
AMP-activated
(AMPK),
miRNA.
processes
autophagy
and
ferroptosis
(an
iron-dependent
form
programmed
cell
death)
play
pivotal
roles
in
regulation
cancers.
Clinical
trials
preclinical
investigations
have
been
conducted
on
many
signaling
pathways
during
development
NEPC,
deepening
research,
appear
to
be
for
regulating
NEPC.
Due
dual
nature
gaining
deeper
understanding
developmental
programs
achieving
may
enhance
stratification
efficacy
patients
Environmental Science & Technology,
Год журнала:
2023,
Номер
57(44), С. 17099 - 17109
Опубликована: Окт. 25, 2023
Poly-
and
perfluoroalkyl
acids
(PFAAs)
are
a
large
family
of
widespread
contaminants
worldwide
concern
well-known
as
"forever
chemicals".
Direct
emission
PFAAs
from
the
fluorochemical
industry
is
crucial
source
PFAA
pollutants
in
environment.
This
study
implemented
nontarget
analysis
comprehensive
characterization
for
category
new
contaminants,
i.e.,
iodinated
(IPFAAs),
wastewater
relevant
contaminated
river
water
by
liquid
chromatography–high-resolution
mass
spectrometry
with
cascade
precursor
ion
exclusion
(PIE)
strategy
in-house
developed
data
extraction
processing
algorithms.
A
total
26
IPFAAs
(including
2
isomers
an
IPFAA)
were
found
identified
tentative
molecular
structures.
Semiquantification
was
implemented,
concentrations
0.16–285.52
0.15–0.17
μg/L
water,
respectively.
The
high
association
predicted
ecotoxicities
environmental
behaviors
demonstrate
that
these
worthy
more
further
in-depth
research.
PIE
along
algorithms
can
be
extended
to
other
beyond
IPFAAs.
identification
outcomes
provide
understanding
on
occurrence
pollution
status
perspective.
Environment & Health,
Год журнала:
2024,
Номер
2(6), С. 332 - 349
Опубликована: Фев. 28, 2024
In
recent
years,
rapid
industrial
development
has
resulted
in
the
production
and
exposure
of
a
substantial
number
compounds
to
human
body.
This
created
an
urgent
need
environmental
toxicology
for
models
that
are
efficient,
accurate,
cost-effective
evaluating
health
impacts
these
on
humans.
Over
past
seven
decades,
various
cancer
cell
lines
immortalized
have
made
significant
contributions
advancement
research
organ
toxicity.
Pluripotent
stem
technology,
especially
toxicological
derived
from
pluripotent
cells,
presents
modern
toxicologists
with
high-throughput,
species-relevant,
predictive
options.
this
comprehensive
review,
we
assess
characteristics
representative
toxicology,
as
well
introduce
two
distinct
types
their
innovative
models.
We
explore
applications
prospects
field
while
also
addressing
readiness
vitro
confront
emerging
challenges
future.
