Human Health Water Quality Criteria: Research Challenges and Priorities DOI
Xiaolei Wang, Xiaoli Zhao, Ying Wang

и другие.

ACS ES&T Water, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Human health water quality criteria (HHWQC) define safe contaminant levels in surface to protect human and are a crucial foundation for environment management. However, many countries lack methods deriving HHWQC. This Perspective reviews recent advancements proposes set of scientific methodologies. To enhance the scientificity practicability HHWQC, four key challenges priorities identified. (i) Region-based parameters essential reflecting local environmental conditions exposure patterns, yet they often lacking countries, necessitating comprehensive fundamental databases. (ii) The increasing contaminants make it challenging derive toxicological reference values (TRVs) using traditional animal experiments, which may be addressed by integrating vitro high-throughput bioassays with PBPK models. (iii) Default uniform relative source contribution (RSC) under- or overestimate could refined incorporating external internal assessments. (iv) Deterministic commonly used HHWQC derivation considered inaccurate rudimentary, whereas probabilistic approaches more effective accounting uncertainty variability input variables. paper is advancing development improving global protection management system from perspective.

Язык: Английский

High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage DOI Creative Commons
Yunjia Lai, Jeremy P. Koelmel, Douglas G. Walker

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(29), С. 12784 - 12822

Опубликована: Июль 10, 2024

In the modern "omics" era, measurement of human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics metabolomics, has emerged as leading technology to broadly profile chemical exposure agents related biomolecules for accurate measurement, high sensitivity, rapid data acquisition, increased resolution space. Non-targeted approaches are increasingly accessible, supporting shift from conventional hypothesis-driven, quantitation-centric targeted analyses toward data-driven, hypothesis-generating exposome-wide profiling. However, HRMS-based exposomics encounters unique challenges. New analytical computational infrastructures needed expand analysis coverage through streamlined, scalable, harmonized workflows pipelines that permit longitudinal tracking, retrospective validation, multi-omics integration meaningful health-oriented inferences. this article, we survey literature on state-of-the-art technologies, review current informatic pipelines, provide an up-to-date reference exposomic chemists, toxicologists, epidemiologists, care providers, stakeholders health sciences medicine. We propose efforts benchmark fit-for-purpose platforms expanding space, including gas/liquid chromatography-HRMS (GC-HRMS LC-HRMS), discuss opportunities, challenges, strategies advance burgeoning field exposome.

Язык: Английский

Процитировано

22
Current and emerging issues in chemical food safety DOI
Chen Liu, Danlei Wang, Ivonne M.C.M. Rietjens

и другие.

Current Opinion in Food Science, Год журнала: 2025, Номер unknown, С. 101284 - 101284

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

2
Chemical Introductions to the Systems: Point Source Pollution (Persistent Chemicals) DOI

Jean‐Paul Ducrotoy

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 170 - 217

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

7
Global Trends and Hotspots in Research on the Health Risks of Organophosphate Flame Retardants: A Bibliometric and Visual Analysis DOI Creative Commons
Zhiyuan Du,

Yuanyuan Ruan,

Jiabin Chen

и другие.

Toxics, Год журнала: 2024, Номер 12(6), С. 391 - 391

Опубликована: Май 27, 2024

Background: Organophosphate flame retardants (OPFRs) are compounds with a wide range of industrial and commercial applications mainly used as plasticizers. The global consumption OPFRs has risen rapidly in recent decades, they have been widely detected environmental media. Unfortunately, associated many adverse health outcomes. issue the risks is attracting increasing attention. Therefore, there need to review current state research trends this field help researchers policymakers quickly understand field, identify new directions, allocate appropriate resources for further development OPFR risk field. Methods: This study statistically analyzed 1162 relevant publications included Web Science Core Collection from 2003–2023. internal external features literature, such publication trends, countries, authors, journals, keywords, were quantitatively visually presented hotspots, compositions, paradigms horizontally vertically analyze structural evolution Results: can be divided into three stages, entered period rapid 2016. China (649 papers) most prolific country, followed by United States (188 papers). authors STAPLETON HM WANG Y highest combined impact. International collaboration between countries still needs strengthened. Total Environment frequently published journal (162 papers), Environmental Technology cited (5285 citations). Endocrine disruption, developmental toxicity, neurotoxicity effects greatest interest. Conclusions: Future expected multidisciplinary, hotspots may involve comprehensive assessment exposure population, exploration mechanisms endocrine-disrupting vivo metabolic processes, examination metabolites.

Язык: Английский

Процитировано

6
Adipogenic Effects of Cresyl Diphenyl Phosphate (Triphenyl Phosphate Alternative) through Peroxisome Proliferator-Activated Receptor Gamma Pathway: A Comprehensive Study Integrating In Vitro, In Vivo, and In Silico from Molecule to Health Risk DOI

Lanchao Sun,

Xinya Liu,

Jingyue Du

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(42), С. 18631 - 18641

Опубликована: Окт. 9, 2024

Cresyl diphenyl phosphate (CDP), a novel organophosphate ester (OPE), has been detected in various environmental and human samples. However, there is very limited knowledge regarding its toxicity, mechanisms of action, potential health risks. Using new alternative methods (NAMs), across the molecular interactions, signaling pathways, cell functions, animal effects, population risks, we investigated adipogenic effects associated risks CDP legacy OPE triphenyl (TPHP) by acting on peroxisome proliferator-activated receptor gamma (PPARγ). Among 19 screened OPEs, bound to PPARγ with highest binding potency, followed TPHP. activated through fitting into pocket strong hydrophobicity hydrogen bond interactions; exhibited higher potency compared In 3T3-L1 cells, enhanced PPARγ-mediated adipogenesis activity, exhibiting greater than The intracellular concentration receptor-bound concentrations (RBC) were also those TPHP both HEK293 cells cells. mice, exposure pathway, leading an increased white adipose tissue weight gain. Overall, could bind activate PPARγ, thereby promoting preadipocyte differentiation development tissue. Its obesogenic should be high concern.

Язык: Английский

Процитировано

4
Seminar: Functional Exposomics and Mechanisms of Toxicity—Insights from Model Systems and NAMs DOI Creative Commons
Yunjia Lai, Muhammet Ay, Carolina Duarte Hospital

и другие.

Environmental Health Perspectives, Год журнала: 2024, Номер 132(9)

Опубликована: Сен. 1, 2024

Significant progress has been made over the past decade in measuring chemical components of exposome, providing transformative population-scale frameworks probing etiologic link between environmental factors and disease phenotypes. While analytical technologies continue to evolve with reams data being generated, there is an opportunity complement exposome-wide association studies (ExWAS) functional analyses advance search at organismal, cellular, molecular levels.

Язык: Английский

Процитировано

3
Aryl Organophosphate Esters and Hemostatic Disruption: Identifying Risk through Machine Learning and Experimental Validation DOI
Pu Chen, Ziyuan Li, Miao Gan

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Organophosphate esters (OPEs) have emerged as a significant environmental concern due to their widespread occurrence and potential human health risks. The presence of OPEs in blood suggests direct interactions with hematological components, which may compromise hemostatic balance lead adverse outcomes. Despite the critical role maintaining stability, effects on this system remain poorly understood. This investigation was undertaken delineate mechanisms that modulate hemostasis, utilizing silico approach high-throughput vitro investigation. We analyzed 85 environmentally prevalent for structural descriptors affinity proteins essential function. multiple linear regression implicated aryl-OPEs, distinguished by benzene ring scaffold, potent disruptors balance. analysis result rigorously validated through assays. Further network toxicology, artificial intelligence (α-Fold) algorithms, an agonist cotreatment assay revealed proliferator-activated receptor γ (PPARγ) key mediator aryl-OPEs induced disruption. By integrating experimental insights vivo exposure data, we concluded specific such bisphenol bis (diphenyl phosphate) (BDP) cresyl diphenyl phosphate (CDP), pose moderate risk general population. Our findings not only contribute prioritization management but also establish methodology assessing toxicity emerging pollutants.

Язык: Английский

Процитировано

0
Integrating In Vitro Data and Physiologically Based Kinetic Modeling to Predict and Compare Acute Neurotoxic Doses of Saxitoxin in Rats, Mice, and Humans DOI Creative Commons
Jiaqi Chen, Annelies Noorlander, Sebastiaan Wesseling

и другие.

Environmental Science & Technology, Год журнала: 2023, Номер 57(30), С. 10974 - 10984

Опубликована: Июль 21, 2023

Current climate trends are likely to expand the geographic distribution of toxigenic microalgae and concomitant phycotoxins, making intoxications by such toxins a global phenomenon. Among various saxitoxin (STX) acts as neurotoxin that might cause severe neurological symptoms in mammals following consumptions contaminated seafood. To derive point departure (POD) for human health risk assessment upon acute neurotoxicity induced oral STX exposure, physiologically based kinetic (PBK) modeling-facilitated quantitative vitro vivo extrapolation (QIVIVE) approach was employed. The PBK models rats, mice, humans were built using parameters from literature, experiments, silico predictions. Available toxicity data converted dose–response curves via established these three species, POD values derived predicted compared reported data. Interspecies differences between rodents found, they appeared be mainly due toxicokinetics. described resulted adequate predictions indicating new methodologies, when appropriately integrated, can used 3R-based chemical paradigm.

Язык: Английский

Процитировано

6
Interactions of organophosphate flame retardants with human drug transporters DOI Creative Commons
Valentin Tastet,

Marc Le Vée,

Marie Kerhoas

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 263, С. 115348 - 115348

Опубликована: Авг. 17, 2023

Organophosphate flame retardants (OPFRs) are environmental pollutants of increasing interest, widely distributed in the environment and exerting possible deleterious effects towards human health. The present study investigates vitro their interactions with drug transporters, which targets for chemicals actors toxicokinetics. Some OPFRs, i.e., tris(2-butoxyethyl) phosphate (TBOEP), tris(1,3-dichloroisopropyl) (TDCPP), tri-o-cresyl (TOCP) triphenyl (TPHP), were found to inhibit activities some such as organic anion transporter 3 (OAT3), transporting polypeptide (OATP) 1B1, OATP1B3, cation 2 (OCT2) or breast cancer resistance protein (BCRP). These concentration-dependent, IC50 values ranging from 6.1 µM (for TDCPP-mediated inhibition OCT2) 51.4 TOCP-mediated BCRP). OPFRs also blocked transporter-dependent membrane passage endogenous substrates, notably that hormones. OAT3 however failed transport TBOEP TPHP. additionally repressed mRNA expressions transporters cultured hepatic HepaRG cells, especially those OAT2 OCT1 response TOCP, 2.3 2.5 µM, respectively. data therefore add expanding list interacting even if OPFR concentrations required impact 2–50 range, rather higher than observed humans environmentally dietarily exposed these chemicals.

Язык: Английский

Процитировано

6
Occupational exposure to traditional and emerging organophosphate esters: A comparison of levels across different sources and blood distribution DOI Creative Commons

Jingren Cui,

Yanhui Ge,

Meiqi Guo

и другие.

Environment International, Год журнала: 2024, Номер 194, С. 109165 - 109165

Опубликована: Ноя. 22, 2024

Язык: Английский

Процитировано

2