Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity

Journal of Hazardous Materials, Год журнала: 2023, Номер 459, С. 132265 - 132265

Опубликована: Авг. 15, 2023

Язык: Английский

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Four-week repeated exposure to tire-derived 6-PPD quinone causes multiple organ injury in male BALB/c mice

The Science of The Total Environment, Год журнала: 2023, Номер 894, С. 164842 - 164842

Опубликована: Июнь 17, 2023

Язык: Английский

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Urine Excretion, Organ Distribution, and Placental Transfer of 6PPD and 6PPD-Quinone in Mice and Potential Developmental Toxicity through Nuclear Receptor Pathways

Environmental Science & Technology, Год журнала: 2023, Номер 57(36), С. 13429 - 13438

Опубликована: Авг. 29, 2023

The rubber antioxidant 6PPD has gained significant attention due to its highly toxic transformation product, 6PPD-quinone (6PPDQ). Despite their detection in urines of pregnant women, the placental transfer and developmental toxicity 6PPDQ are unknown. Here, we treated C57Bl/6 mice with 4 mg/kg or investigate urine excretion transfer. Female male exhibited sex difference profiles 6PPDQ. Urine concentrations were one order magnitude lower than those 6PPD, suggesting higher bioaccumulation In from embryonic day 11.5 15.5, showed ∼1.5–8 times placenta, embryo body, brain, Using vitro dual-luciferase reporter assays, revealed that activated human retinoic acid receptor α (RARα) retinoid X (RXRα) at as low 0.3 μM, which was ∼10-fold detected urines. RXRα 1.2 μM. These results demonstrate exposure risks during pregnancy emphasize need for further toxicological epidemiological investigations.

Язык: Английский

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Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans

Environmental Science & Technology, Год журнала: 2023, Номер 57(48), С. 19295 - 19303

Опубликована: Ноя. 8, 2023

N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD), one of the most common additives used in rubber, enters environment due to significant emissions tire wear particles. 6-PPD quinone (6-PPDQ) is an important derivative after ozonization. With concentrations ranging from nanograms per liter μg/L, 6-PPDQ has so far been identified a series water samples. Acute lethality coho salmon (LC50 < 1 μg/L) was lower than environmental 6-PPDQ, highlighting exposure risks 6-PPDQ. It becoming increasingly necessary investigate potential toxicity at concentrations. Here, we examined effect on lifespan and healthspan underlying mechanism Caenorhabditis elegans. Exposure (1 10 shortened lifespan. Meanwhile, during aging process, (0.1–10 could decrease both pumping rate locomotion behavior, suggesting healthspan. For molecular mechanism, dysregulation insulin signaling pathway linked In pathway, DAF-2 restricted function DAF-16 activate downstream targets (SOD-3 HSP-6), which turn controlled Additionally, response toxicity, peptides (INS-6, INS-7, DAF-28) corresponding receptor DAF-2. Therefore, environmentally relevant potentially causes damage by activating organisms.

Язык: Английский

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Comparison of reproductive toxicity between pristine and aged polylactic acid microplastics in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 466, С. 133545 - 133545

Опубликована: Янв. 17, 2024

Язык: Английский

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Polyethylene nanoparticles at environmentally relevant concentrations enhances neurotoxicity and accumulation of 6-PPD quinone in Caenorhabditis elegans

The Science of The Total Environment, Год журнала: 2024, Номер 918, С. 170760 - 170760

Опубликована: Фев. 6, 2024

Язык: Английский

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Evaluation of 6-PPD quinone toxicity on lung of male BALB/c mice by quantitative proteomics

The Science of The Total Environment, Год журнала: 2024, Номер 922, С. 171220 - 171220

Опубликована: Фев. 25, 2024

Язык: Английский

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Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegans

The Science of The Total Environment, Год журнала: 2024, Номер 927, С. 172306 - 172306

Опубликована: Апрель 7, 2024

Язык: Английский

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Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 471, С. 134356 - 134356

Опубликована: Апрель 19, 2024

Язык: Английский

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Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation

The Science of The Total Environment, Год журнала: 2024, Номер 918, С. 170679 - 170679

Опубликована: Фев. 5, 2024

Язык: Английский

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