Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity

Journal of Hazardous Materials, Год журнала: 2023, Номер 459, С. 132265 - 132265

Опубликована: Авг. 15, 2023

Язык: Английский

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Widespread occurrence of two typical N, N’-substituted p-phenylenediamines and their quinones in humans: Association with oxidative stress and liver damage

Journal of Hazardous Materials, Год журнала: 2024, Номер 468, С. 133835 - 133835

Опубликована: Фев. 19, 2024

Язык: Английский

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Polyethylene nanoparticles at environmentally relevant concentrations enhances neurotoxicity and accumulation of 6-PPD quinone in Caenorhabditis elegans

The Science of The Total Environment, Год журнала: 2024, Номер 918, С. 170760 - 170760

Опубликована: Фев. 6, 2024

Язык: Английский

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Evaluation of 6-PPD quinone toxicity on lung of male BALB/c mice by quantitative proteomics

The Science of The Total Environment, Год журнала: 2024, Номер 922, С. 171220 - 171220

Опубликована: Фев. 25, 2024

Язык: Английский

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Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegans

The Science of The Total Environment, Год журнала: 2024, Номер 927, С. 172306 - 172306

Опубликована: Апрель 7, 2024

Язык: Английский

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Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 471, С. 134356 - 134356

Опубликована: Апрель 19, 2024

Язык: Английский

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Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation

The Science of The Total Environment, Год журнала: 2024, Номер 918, С. 170679 - 170679

Опубликована: Фев. 5, 2024

Язык: Английский

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Chronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice

Journal of Hazardous Materials, Год журнала: 2024, Номер 470, С. 134165 - 134165

Опубликована: Март 28, 2024

Язык: Английский

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Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone

Environment International, Год журнала: 2024, Номер 187, С. 108677 - 108677

Опубликована: Апрель 21, 2024

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is commonly used in rubber compounds as antioxidants to protect against degradation from heat, oxygen, and ozone exposure. This practice extends the lifespan of products, including tires, by preventing cracking, aging, deterioration. However, environmental consequences waste generated during product use, particularly formation 6PPD-quinone (6PPD-Q) through reaction 6PPD with ozone, have raised significant concerns due their detrimental effects on ecosystems. Extensive research has revealed widespread occurrence its derivate 6PPD-Q various compartments, air, water, soil. The emerging substance been shown pose acute mortality long-term hazards aquatic terrestrial organisms at concentrations below environmentally relevant levels. Studies demonstrated toxic a range organisms, zebrafish, nematodes, mammals. These include neurobehavioral changes, reproductive dysfunction, digestive damage exposure pathways. Mechanistic insights suggest that mitochondrial stress, DNA adduct formation, disruption lipid metabolism contribute toxicity induced 6PPD-Q. Recent findings human samples, such blood, urine, cerebrospinal fluid, underscore importance further public health toxicological implications these compounds. distribution, fate, biological effects, underlying mechanisms environment highlight urgent need for additional understand address impacts

Язык: Английский

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Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 472, С. 134598 - 134598

Опубликована: Май 13, 2024

Язык: Английский

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