In‐vitro and In‐vivo Photocatalytic Cancer Therapy with Biocompatible Iridium(III) Photocatalysts

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(17), С. 9474 - 9479

Опубликована: Янв. 15, 2021

Abstract Photocatalytic anticancer profile of a Ir III photocatalyst ( Ir3 ) with strong light absorption, high turnover frequency, and excellent biocompatibility is reported. showed selective photo‐cytotoxicity against cisplatin‐ sorafenib‐resistant cell lines while remaining dormant to normal in the dark. exhibited photo‐catalytic oxidation cellular co‐enzyme, reduced nicotinamide adenine dinucleotide phosphate (NADPH), amino acids via single electron transfer mechanism. The photo‐induced intracellular redox imbalance change mitochondrial membrane potential resulted necrosis apoptosis cancer cells. Importantly, efficiency as evident from vivo zebrafish mouse models. To best our knowledge, first based such photocatalytic therapeutic effect.

Язык: Английский

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Bisphenol A and its substitutes in the aquatic environment: Occurrence and toxicity assessment

Chemosphere, Год журнала: 2023, Номер 315, С. 137763 - 137763

Опубликована: Янв. 6, 2023

Язык: Английский

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The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases

Cell Reports Medicine, Год журнала: 2024, Номер 5(6), С. 101581 - 101581

Опубликована: Май 22, 2024

Non-communicable diseases (NCD) constitute one of the highest burdens disease globally and are associated with inflammatory responses in target organs. There is increasing evidence significant human exposure to micro- nanoplastics (MnPs). This review environmental MnP health impacts indicates that particles, directly indirectly through their leachates, may exacerbate inflammation. Meanwhile, persistent inflammation NCDs gastrointestinal respiratory systems potentially increases uptake, thus influencing access distal Consequently, a future increase augments risk severity NCDs. critical need for an integrated one-health approach research assessing drivers bidirectional links Assessing these risks requires interdisciplinary efforts identify link organismal uptake studies impacted mechanisms outcomes.

Язык: Английский

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Exploring BPA alternatives – Environmental levels and toxicity review

Environment International, Год журнала: 2024, Номер 189, С. 108728 - 108728

Опубликована: Май 23, 2024

Bisphenol A alternatives are manufactured as potentially less harmful substitutes of bisphenol (BPA) that offer similar functionality. These already in the market, entering environment and thus raising ecological concerns. However, it can be expected levels BPA will dominate future, they limited information on their environmental safety. The EU PARC project highlights priority chemicals consolidates alternatives, with a focus relevance identification research gaps. review highlighted aspects future perspectives. In brief, an extension monitoring is crucial, extending to cover track facilitate timely implementation mitigation measures. biological activity has been studied for but non-systematic way prioritized number chemicals. For several data provided substantial evidence regarding potential harm environment. We stress importance conducting more comprehensive assessments go beyond traditional reproductive studies overlooked relevant endpoints. Future should also consider mixture effects, realistic concentrations, long-term consequences biota ecosystems.

Язык: Английский

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Beyond microbeads: Examining the role of cosmetics in microplastic pollution and spotlighting unanswered questions

Journal of Hazardous Materials, Год журнала: 2024, Номер 476, С. 135053 - 135053

Опубликована: Июнь 27, 2024

The presence of microplastics in cosmetics and personal care products (C&PCPs) has been increasingly the public eye since early 2010s. Despite increasing research into potential environmental health effects microplastics, most to date on C&PCPs investigated "rinse-off" products, while impacts "leave-on" have largely neglected, despite these being purchased greater volumes often having two or more microplastic ingredients their formulations(CosmeticsEurope, 2018b). This review aims synthesize current knowledge C&PCPs, assessing human discussing regulatory implications. lack studies leave-on is significant, suggesting a severe gap regarding in, emissions from, C&PCPs. There noticeable (eco)toxicological consequences exposure from As result, significant aspects contamination may be overlooked legislations emerging globally (including European Commission), which intend restrict use but focus rinse-off only. highlights for decision-making, particularly as alternatives are considered during phase-out periods spotlights need sufficient monitoring alternatives, avoid unforeseen consequences.

Язык: Английский

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Emissions from corrosion protection systems of offshore wind farms: Evaluation of the potential impact on the marine environment

Marine Pollution Bulletin, Год журнала: 2018, Номер 136, С. 257 - 268

Опубликована: Сен. 20, 2018

Offshore wind energy is a fast growing sector of renewable energies worldwide. This will change the marine environment and thus, wide range environmental impacts offshore farms are subject current research. Here we present an overview about chemical emissions from corrosion protection systems, discuss their relevance potential impact to environment, suggest strategies reduce emissions. Corrosion general problem for infrastructures systems necessary maintain structural integrity. These often in direct contact with seawater have different potentials emissions, e.g. galvanic anodes emitting substantial amounts metals. Organic coatings may release organic substances due weathering and/or leaching. Current assumptions suggesting low impact, but monitoring data not sufficient assess this new source.

Язык: Английский

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Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents

Diabetes & Metabolism Journal, Год журнала: 2019, Номер 43(1), С. 59 - 59

Опубликована: Янв. 1, 2019

Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as substitutes for A (BPA), an environmental obesogen. However, health effects of BPF BPS remain unclear. In this study, we evaluated the associations BPA, BPF, with obesity in children adolescents.We data from U.S. National Health Nutrition Examination Survey 2013 to 2014, a nationally representative study. We included 745 participants aged 6 17 years old. General was defined based on 2000 Centers Disease Control Prevention body mass index-for-age growth charts United States. Abdominal waist-to-height ratio ≥0.5.After adjustment demographic, socioeconomic lifestyle factors, urinary creatinine levels, odds general comparing highest lowest quartile levels 1.74 (95% confidence interval [CI], 0.92 3.31) 1.54 CI, 1.02 2.32) 1.36 0.53 3.51) BPS. Moreover, were stronger boys than girls BPA BPF. Similar results observed abdominal obesity.This study first time showed that exposure commonly substitute positively associated higher risk adolescents. The association primarily boys, suggesting possible sex difference. Further investigations underlying mechanisms needed.

Язык: Английский

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Degradation of bisphenol AF in water by periodate activation with FeS (mackinawite) and the role of sulfur species in the generation of sulfate radicals

Chemical Engineering Journal, Год журнала: 2020, Номер 407, С. 126738 - 126738

Опубликована: Авг. 24, 2020

Язык: Английский

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The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms

Journal of Hazardous Materials, Год журнала: 2020, Номер 406, С. 124303 - 124303

Опубликована: Окт. 19, 2020

Язык: Английский

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Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

Environmental Sciences Europe, Год журнала: 2020, Номер 32(1)

Опубликована: Сен. 29, 2020

Abstract Background The Fish Embryo Acute Toxicity (FET) test with the zebrafish ( Danio rerio ) embryo, OECD guideline (TG) 236, has been designed as an alternative for acute fish toxicity testing such Test (TG 203). To provide equivalent sensitivity to test, original FET was use only four morphological core endpoints: coagulation of lack somite formation, heart beat, and non-detachment tail. These endpoints were selected due (1) their association mortality, directly or indirectly, (2) improve practicality screening by well-trained technical staff, (3) being relatively simple alterations. Results With growing need understand developmental compounds found in environment, protocol repeatedly extended a multitude additional that also allow monitoring teratogenicity. As extensive generated observations scientific literature, harmonisation terminology used description effects seen after chemical exposure become necessary. Conclusion For this end, present communication provides overview both common more specific embryos wide variety substances together suggestions harmonised nomenclature.

Язык: Английский

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