The
development
of
light-triggered
ruthenium
(Ru)
nanophotocages
has
revolutionized
conventional
methods
drug
administration,
thereby
facilitating
cancer
therapy
in
a
noninvasive
and
temperate
manner.
Ru
employ
distinct
approach
known
as
photoactivated
chemotherapy
(PACT),
wherein
light-induced
ligand
dissociation
yields
toxic
metal
complex
or
capable
performing
other
functions
such
optically
controlled
protein
degradation
delivery.
Simultaneously,
this
process
is
accompanied
by
the
generation
reactive
oxygen
species
(ROS),
which
serve
an
effective
anticancer
agent
combination
with
PACT
photodynamic
(PDT).
Due
to
its
exceptional
attributes
extended
tissue
penetration,
minimized
damage,
red
light
near-infrared
widely
acknowledged
"phototherapeutic
window"
(650-900
nm).
In
Concept,
we
present
overview
most
recent
advancements
within
phototherapeutic
range.
Diverse
aspects,
including
design
principles,
photocaging
efficacy,
photoactivation
mechanisms,
potential
applications
field
biomedical
chemistry,
are
discussed.
Questions
challenges
regarding
their
synthesis,
characterization,
also
This
Concept
would
foster
further
exploration
into
realm
nanophotocages.
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
670, С. 234 - 245
Опубликована: Май 16, 2024
The
clinical
translation
of
photosensitizers
based
on
ruthenium(II)
polypyridyl
complexes
(RPCs)
in
photodynamic
therapy
cancer
faces
several
challenges.
To
address
these
limitations,
we
conducted
an
investigation
to
assess
the
potential
a
cubosome
formulation
stabilized
water
against
coalescence
utilizing
polyphosphoester
analog
Pluronic
F127
as
stabilizer
and
loaded
with
newly
synthesized
RPC-based
photosensitizer
[Ru(dppn)
Bioinorganic Chemistry and Applications,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Sarcoplasmic
reticulum
Ca
2+
‐ATPase
(SERCA)
is
a
key
protein
involved
in
calcium
homeostasis
and
the
pivotal
role
of
plethora
biological
activities
makes
SERCA
powerful
target.
The
intertwining
between
signalling
reactive
oxygen
species
(ROS)
has
drawn
much
attention
to
investigate
photodynamic
effect
that
photosensitizers
(PSs),
prodrugs
are
light‐activated
produce
ROS
therapy
(PDT),
pursue
on
this
important
However,
only
limited
classes
PSs
were
considered
so
far,
with
most
them
being
porphyrin‐based
scaffolds,
without
considering,
best
our
knowledge,
family
ruthenium(II)
polypyridyl
complexes
(RPCs),
which
still
attracts
increasing
interest
PDT
thanks
its
unique
versatile
chemical‐physical
repertoire.
With
goal
exploring
potential
arising
from
considering
possible
target
for
highly
effective
RPC‐based
PSs,
herein
we
studied
[Ru(dppn)
2
(bpy‐morph)](PF
6
)
(RuPS)
(dppn
=
benzo[
i
]dipyrido[3,2‐
:2′,3′‐
c
]phenazine,
bpy‐morph
2,2′‐bipyridine‐4,4′‐diylbis(morpholinomethanone),
where
two
π‐expansive
dppn
units
guarantees
high
1
O
sensitization
(
ϕ
Δ
0.54
±
0.06
CH
3
CN).
To
aim,
solid
supported
membrane
(SSM)
biosensing
method
was
employed,
equipped
LED
light
λ
em
434
nm,
30
W)
perform
irradiation
experiments.
Light
activation
RuPS
(10
μM)
induced
prompt
decrease
(30%)
translocation
by
SERCA,
leading
almost
complete
loss
residual
current
after
15
min
(more
than
90%
decrease).
inhibition
then
evaluated
vivo
C2C12
myotubes,
chosen
as
model
skeletal
muscle
biology.
Upon
establishing
cellular
internalization
via
confocal
microscopy,
found
enhance
cytosolic
concentration
up
1.5‐fold‐higher
thapsigargin,
used
positive
control.
Moreover,
differentiated
phenotype
myotubes
reverted
RuPS,
an
likely
related
impaired
activity
protein.
Future Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown, С. 1 - 18
Опубликована: Янв. 29, 2025
The
rise
of
antibiotic-resistant
Gram-positive
bacterial
infections
poses
a
significant
threat
to
public
health,
necessitating
the
exploration
alternative
therapeutic
strategies.
A
photosensitizer
(PS)
can
convert
energy
from
absorbed
photon
into
reactive
oxygen
species
(ROS)
for
damaging
bacteria.
This
photoinactivation
action
bypassing
conventional
antibiotic
mechanism
is
less
prone
resistance
development,
making
antibacterial
photodynamic
therapy
(aPDT)
highly
efficient
in
combating
Photodynamic
transition
metal
complexes
leveraging
unique
properties
metals
enhance
aPDT
activity
are
next-generation
PS.
review
provides
an
overview
metal-based
PS
Based
on
structures,
these
metal-PS
could
be
mainly
classified
as
metal-tetrapyrrole
derivatives,
ruthenium
complexes,
iridium
and
zinc
complexes.
based
other
such
silver,
cobalt,
rhenium
also
presented.
Finally,
we
summarize
advantages
shortcomings
metal-
PS,
conclude
some
critical
aspects
impacting
their
performances
give
perspective
future
development.
Abstract
Ruthenium(II)
and
iridium(III)
complexes
of
phosphinites
including
imidazole
moiety
were
synthesized
characterized
by
microanalysis,
IR,
MS,
NMR
spectroscopies.
Antibacterial
activity
against
Gram‐positive
Gram‐negative
bacterial
strains
was
assessed
in
all
complexes.
The
highest
radical
scavenging
(72.2
%)
obtained
for
[3‐(3‐chloro‐2‐({[dichloro(η
6
‐benzene)ruthenium]diphenylphosphanyl}oxy)propyl)‐1‐butyl‐1H‐imidazol‐3‐ium
chloride],
4
at
200
μg/mL
concentration,
while
5
‐pentamethylcyclopentadienyl)‐iridium]diphenylphosphanyl}oxy)pro‐pyl)‐1‐butyl‐1H‐imidazol‐3‐ium
demonstrated
the
antibacterial
as
13
mm
inhibition
zone
E.
hirea
.
Furthermore,
optical
electrochemical
featured
metal
containing
phosphinite
investigated
utilizing
UV–vis
absorption
cyclic
voltammetry
techniques.
Consequently,
can
be
proposed
metal‐based
charge
convertible
which
may
employed
new
generation
synergistic
Dye‐Sensitized
Solar
Cell
(DSSC)
materials.
JBIC Journal of Biological Inorganic Chemistry,
Год журнала:
2024,
Номер
29(5), С. 511 - 518
Опубликована: Июнь 26, 2024
Antimicrobial
resistance
(AMR)
has
been
emerging
as
a
major
global
health
threat
and
calls
for
the
development
of
novel
drug
candidates.
Metal
complexes
have
demonstrating
high
efficiency
antibacterial
agents
that
differ
substantially
from
established
types
antibiotics
in
their
chemical
structures
mechanism
action.
One
strategy
to
exploit
this
potential
is
design
metal-based
hybrid
organometallics
consist
an
antibiotic
warhead
contributes
additional
action
different
parent
antibiotic.
In
communication,
we
describe
organometallic
2c,
which
metronidazole
connected
gold(I)
N-heterocyclic
carbene
inhibits
bacterial
thioredoxin
reductase
(TrxR).
Metronidazole
can
be
used
treatment
with
obligatory
anaerobic
pathogen
Clostridioides
difficile
(C.
difficile),
however,
hampers
its
clinical
success.
The
gold
conjugate
2c
was
efficient
inhibitor
TrxR
it
inactive
or
showed
only
minor
effects
against
eucaryotic
cells
bacteria
grown
under
aerobic
conditions.
contrast,
strong
effect
observed
both
metronidazole-sensitive
-resistant
strains
C.
difficile.
This
report
presents
proof-of-concept
viable
approach
efficiently
tackle
AMR.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(38)
Опубликована: Май 8, 2024
Ruthenium(II)
polypyridyl
complexes
continue
to
raise
increasing
interest
for
the
encouraging
results
in
several
biomedical
areas.
Considering
their
vast
chemical-physical
repertoire,
particular
possibility
switch
from
sensitization
of
reactive
oxygen
species
(ROS)
ROS-scavenging
abilities
by
tuning
nature
ligands,
it
is
therefore
surprising
that
potential
as
antioxidants
has
not
been
largely
investigated
so
far.
Herein,
we
explored
antioxidant
behaviour
novel
ruthenium
compound
[Ru(dbpy)(2,3-DAN)Cl]PF
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 11, 2024
Abstract
Three
novel
polypyridyl‐Co(III)‐vitamin
B
6
complexes
viz
.,
[Co(CF
3
‐phtpy)(SBVB
)]Cl
(
Co1
),
[Co(anthracene‐tpy)(SBVB
Co2
[Co(NMe
2
Co3
where
4’‐(4‐(trifluoromethyl)phenyl)‐2,2’:6’,2’’‐terpyridine=CF
‐phtpy,
4’‐(anthracen‐9‐yl)‐2,2’:6’,2’’‐terpyridine=anthracene‐tpy;,
4‐([2,2’:6’,2’’‐terpyridin]‐4’‐yl)‐N,N‐dimethylaniline=NMe
(E)‐5‐(hydroxymethyl)‐4‐(((2‐hydroxyphenyl)imino)methyl)‐2‐methylpyridin‐3‐ol=H
SBVB
were
successfully
developed
for
aPDT
(antibacterial
photodynamic
therapy)
applications.
–
exhibited
an
intense
absorption
band
at
ca
.
435–485
nm,
which
is
attributed
to
ligand‐to‐metal
charge
transfer
and
was
beneficial
antibacterial
therapy.
The
distorted
octahedral
geometry
of
the
with
Co
III
N
4
O
core
evident
from
DFT
study.
visible
light
ability
good
photo‐stability
made
them
photosensitizers
aPDT.
displayed
significant
responses
against
gram‐positive
S.
aureus
)
gram‐negative
E.
coli
bacteria
upon
exposure
(10
J
cm
−2
,
400–700
nm)
showed
MIC
values
between
0.01–0.005
μg
mL
−1
activities
these
due
their
damage
bacterial
cell
membranes
via
ROS
generation.
Overall,
this
study
shows
photo‐triggered
ROS‐mediated
bacteria‐killing
potential
Co(III)
complexes.
