Food Science and Human Wellness,
Год журнала:
2021,
Номер
11(1), С. 11 - 21
Опубликована: Сен. 11, 2021
The
metabolic
syndrome
(MS)
has
become
one
of
the
main
problems
in
public
health.
Tea
polyphenols
(TPs),
bioactive
components
tea,
been
claimed
to
have
potential
regulate
metabolism
and
effectively
prevent
or
mitigate
MS.
However,
many
studies
into
effects
TPs
on
MS
provided
conflicting
findings
underlying
mechanism
elusive.
predominant
unfermentedand
fermented
tea
are
catechins
oxidized
(theaflavins
thearubigins),
both
which
low
bioavailability
reach
colon
where
most
gut
microbes
inhabit.
Gut
microbiota
demonstrated
be
tightly
associated
with
host
metabolism.
interactions
between
will
lead
alterations
composition
production
metabolites
including
short
chain
fatty
acids,
bile
amino
acids
derived
metabolites,
accordingly
exerting
their
biological
locally
systemically.
This
review
highlighted
contribution
specific
bacteria
process
intervention
further
discuss
how
impact
via
from
viewpoint
organ/tissue
axis.
Chemical Reviews,
Год журнала:
2021,
Номер
121(17), С. 10367 - 10451
Опубликована: Июль 6, 2021
Since
the
industrial
revolution,
rapid
growth
and
development
of
global
industries
have
depended
largely
upon
utilization
coal-derived
chemicals,
more
recently,
petroleum-based
chemicals.
These
developments
followed
a
linear
economy
model
(produce,
consume,
dispose).
As
world
is
facing
serious
threat
from
climate
change
crisis,
sustainable
solution
for
manufacturing,
i.e.,
circular
in
which
waste
same
or
different
can
be
used
as
feedstocks
resources
production
offers
an
attractive
industrial/business
model.
In
nature,
biological
systems,
microorganisms
routinely
use
their
enzymes
metabolic
pathways
to
convert
organic
inorganic
wastes
synthesize
biochemicals
energy
required
growth.
Therefore,
understanding
how
selected
biobased
into
special
(bio)chemicals
serves
important
basis
build
on
applications
biocatalysis,
engineering,
synthetic
biology
enable
processes
that
are
greener
cleaner
environment.
This
review
article
highlights
current
state
knowledge
regarding
enzymatic
reactions
converting
(lignocellulosic
biomass,
sugar,
phenolic
acid,
triglyceride,
fatty
glycerol)
greenhouse
gases
(CO2
CH4)
value-added
products
discusses
progress
made
engineering.
The
commercial
aspects
life
cycle
assessment
engineering
also
discussed.
Continued
field
would
offer
diversified
solutions
renewable
manufacturing
valuable
Biomedicines,
Год журнала:
2023,
Номер
11(2), С. 294 - 294
Опубликована: Янв. 20, 2023
Gut
microbes
and
their
metabolites
are
actively
involved
in
the
development
regulation
of
host
immunity,
which
can
influence
disease
susceptibility.
Herein,
we
review
most
recent
research
advancements
gut
microbiota–immune
axis.
We
discuss
detail
how
microbiota
is
a
tipping
point
for
neonatal
immune
as
indicated
by
newly
uncovered
phenomenon,
such
maternal
imprinting,
utero
intestinal
metabolome,
weaning
reaction.
describe
shapes
both
innate
adaptive
immunity
with
emphasis
on
short-chain
fatty
acids
secondary
bile
acids.
also
comprehensively
delineate
disruption
axis
results
immune-mediated
diseases,
gastrointestinal
infections,
inflammatory
bowel
cardiometabolic
disorders
(e.g.,
cardiovascular
diabetes,
hypertension),
autoimmunity
rheumatoid
arthritis),
hypersensitivity
asthma
allergies),
psychological
anxiety),
cancer
colorectal
hepatic).
further
encompass
role
fecal
transplantation,
probiotics,
prebiotics,
dietary
polyphenols
reshaping
therapeutic
potential.
Continuing,
examine
modulates
therapies,
including
checkpoint
inhibitors,
JAK
anti-TNF
therapies.
lastly
mention
current
challenges
metagenomics,
germ-free
models,
recapitulation
to
achieve
fundamental
understanding
regulates
immunity.
Altogether,
this
proposes
improving
immunotherapy
efficacy
from
perspective
microbiome-targeted
interventions.
Molecules,
Год журнала:
2021,
Номер
26(13), С. 3907 - 3907
Опубликована: Июнь 26, 2021
Green
tea
can
influence
the
gut
microbiota
by
either
stimulating
growth
of
specific
species
or
hindering
development
detrimental
ones.
At
same
time,
bacteria
metabolize
green
compounds
and
produce
smaller
bioactive
molecules.
Accordingly,
benefits
could
be
due
to
beneficial
microbial
metabolites.
Therefore,
is
likely
act
as
middle
man
for,
at
least,
some
on
health.
Many
health
promoting
effects
seems
related
inter-relation
between
microbiota.
has
proven
able
correct
dysbiosis
that
appears
during
several
conditions
such
obesity
cancer.
On
other
hand,
bacterial
involved
in
inflammatory
processes
release
LPS
modulation
IL
production;
thus,
influencing
different
chronic
diseases.
There
are
many
studies
trying
link
phenolic
via
In
this
review,
we
tried
summarize
most
recent
research
area.
Biomolecules,
Год журнала:
2021,
Номер
11(5), С. 767 - 767
Опубликована: Май 20, 2021
The
potential
to
treat
neurodegenerative
diseases
(NDs)
of
the
major
bioactive
compound
green
tea,
epigallocatechin-3-gallate
(EGCG),
is
well
documented.
Numerous
findings
now
suggest
that
EGCG
targets
protein
misfolding
and
aggregation,
a
common
cause
pathological
mechanism
in
many
NDs.
Several
studies
have
shown
interacts
with
misfolded
proteins
such
as
amyloid
beta-peptide
(Aβ),
linked
Alzheimer’s
disease
(AD),
α-synuclein,
Parkinson’s
(PD).
To
date,
NDs
constitute
serious
public
health
problem,
causing
financial
burden
for
care
systems
worldwide.
Although
current
treatments
provide
symptomatic
relief,
they
do
not
stop
or
even
slow
progression
these
devastating
disorders.
Therefore,
there
an
urgent
need
develop
effective
drugs
incurable
ailments.
It
expected
targeting
can
serve
therapeutic
strategy
since
neurodegeneration.
In
this
context,
may
offer
great
opportunities
drug
discovery
review
critically
discusses
role
provides
updated
information
on
scientific
evidence
potentially
be
used
fatal
brain
Journal of Functional Foods,
Год журнала:
2022,
Номер
100, С. 105365 - 105365
Опубликована: Дек. 18, 2022
The
human
gastrointestinal
tract
harbors
a
diverse
range
of
microbial
species,
which
helps
to
regulate
various
biological
processes
such
as
homeostasis
the
gut
barrier,
stimulation
immune
system,
and
neurological
health
benefits
from
gut-brain
axis.
Further,
microbiome
has
been
found
aid
in
uptake
nutrients
food
large
intestines.
dietary
changes
may
lead
significant
population,
suggest
that
positive
change
can
be
made
diversity
by
changing
style.
potential
substances
positively
enhance
populations
could
antioxidants,
possess
many
multiple
oxidative
stress-related
diseases
cardiovascular
disease,
cancer,
diabetes,
obesity,
etc.
Food
antioxidants
are
necessary
required
body
balance
stress
generated
biochemical
metabolic
reactions.
interactions
between
microbiota
vital
for
maintenance
microbiome,
it
bacteria
influences
bioavailability
increasing
production
bioactive
metabolites
through
microbiome.
It
is
evident
different
studies
food-derived
population
have
an
active
interaction
leading
alleviation
dysbiosis.
A
plethora
clinical
impact
on
microflora
developing
microbe-targeting
therapeutics
diseases.
This
review
discusses
major
antioxidant
groups,
with
these
in-depth
pre-clinical
interventions.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2022,
Номер
21(5), С. 3931 - 3962
Опубликована: Авг. 29, 2022
Abstract
A
large
number
of
epidemiological
studies
have
shown
that
consumption
fruits,
vegetables,
and
beverages
rich
in
(poly)phenols
promote
numerous
health
benefits
from
cardiovascular
to
neurological
diseases.
Evidence
on
has
been
applied
mainly
flavonoids,
yet
the
role
phenolic
acids
largely
overlooked.
Such
phenolics
present
food
combine
with
those
resulting
gut
microbiota
catabolism
flavonoids
chlorogenic
produced
by
endogenous
pathways,
concentrations
low
molecular
weight
metabolites
human
circulation.
Independently
origin,
intervention
using
diets
(poly)phenols,
a
total
137
detected
quantified
circulation
unknown
biological
function.
In
this
review,
we
will
pinpoint
two
main
aspects
metabolites:
(i)
responsible
for
their
generation,
(ii)
analysis
(quali‐
quantitative)
respective
pharmacokinetics.
doing
so,
aim
drive
scientific
advances
regarding
ubiquitous
roles
physiologically
relevant
under
(patho)physiologically
conditions
humans.
Biomolecules,
Год журнала:
2022,
Номер
12(12), С. 1871 - 1871
Опубликована: Дек. 13, 2022
The
misuse
and
abuse
of
antibiotics
in
livestock
poultry
seriously
endanger
both
human
health
the
continuously
healthy
development
breeding
industry.
Plant-derived
bioactive
compounds
(curcumin,
capsaicin,
quercetin,
resveratrol,
catechin,
lignans,
etc.)
have
been
widely
studied
recent
years,
due
to
their
extensive
pharmacological
functions
biological
activities,
such
as
anti-inflammatory,
antioxidant,
antistress,
antitumor,
antiviral,
lowering
blood
glucose
lipids,
improving
insulin
sensitivity.
Numerous
studies
demonstrated
that
plant-derived
are
able
enhance
host’s
ability
resist
or
diminish
diseases
by
regulating
abundance
its
gut
microbiota,
achieving
great
potential
a
substitute
for
antibiotics.
Recent
developments
humans
animals
also
highlighted
major
contribution
microbiota
nutrition,
metabolism,
immunity,
neurological
functions.
Changes
composition
closely
related
obesity
can
lead
numerous
metabolic
diseases.
Mounting
evidence
has
compounds,
especially
curcumin,
improve
intestinal
barrier
function
flora.
Furthermore,
constituents
be
directly
metabolized
flora
further
produce
metabolites
interaction
between
host
This
largely
enhances
protective
effect
on
whole
body
health,
indicating
bidirectional
regulation
application
maintaining
preventing
treating
various
review
mainly
summarizes
latest
research
progress
bioregulation
together
with
animals,
so
provide
theoretical
support
new
feed
additives
substitutes
Overall,
based
this
review,
it
concluded
modulating
hold
promise
toward
animal
husbandry.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
64(19), С. 6546 - 6566
Опубликована: Фев. 2, 2023
Epigallocatechin
gallate
(EGCG),
a
typical
flavone-3-ol
polyphenol
containing
eight
free
hydroxyl
groups,
is
associated
with
variety
of
bioactivities,
such
as
antioxidant,
anti-inflammatory,
anti-cancer,
and
antibacterial
activities.
However,
the
poor
bioavailability
EGCG
restricts
its
use.
In
this
review,
we
discuss
processes
involved
in
absorption
metabolism
EGCG,
focus
on
metabolic
interactions
gut
microbiota.
Next,
summarize
bioactivities
some
key
metabolites,
describe
biotransformation
by
different
microorganisms,
catabolism
specific
bacteria.
A
deeper
understanding
absorption,
metabolism,
may
enable
disease-preventive
therapeutic
properties
to
be
better
utilized.
This
review
provides
theoretical
basis
for
further
development
utilization
metabolites
improving
microbiota
physiological
health.
Nutrients,
Год журнала:
2023,
Номер
15(6), С. 1539 - 1539
Опубликована: Март 22, 2023
Each
person’s
body
is
host
to
a
large
number
and
variety
of
gut
microbiota,
which
has
been
described
as
the
second
genome
plays
an
important
role
in
body’s
metabolic
process
closely
related
health.
It
common
knowledge
that
proper
physical
activity
right
diet
structure
can
keep
us
healthy,
recent
years,
researchers
have
found
this
boost
health
may
be
microbiota.
Past
studies
reported
modulate
compositional
microbiota
further
influence
production
key
metabolites
effective
way
improve
metabolism
prevent
treat
diseases.
In
review,
we
outline
regulating
improving
disorders.
addition,
highlight
regulation
through
appropriate
exercise
diseases,
aiming
promote
public
provide
new
approach
treating
such
