Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Авг. 13, 2024
In
dogs,
chronic
enteropathies,
and
impaired
gut
integrity,
as
well
microbiome
imbalances,
are
a
major
problem.
These
conditions
may
represent
continuous
low
endotoxin
load,
which
result
in
the
development
of
diseases
that
attributable
to
inflammation.
Flavonoids
polyphenolic
plant
compounds
with
numerous
beneficial
properties
such
antioxidant,
anti-inflammatory
antimicrobial
effects.
For
our
experiments,
we
isolated
primary
white
blood
cells
(peripheral
mononuclear
polymorphonuclear
leukocytes)
from
healthy
dogs
induced
inflammation
oxidative
stress
Escherichia
coli
Salmonella
enterica
serovar
Enteritidis
lipopolysaccharide
(LPS).
parallel,
treated
cell
cultures
various
flavonoids
luteolin,
quercetin
grape
seed
extract
oligomeric
proanthocyanidins
(GSOP)
alone
also
combination
LPS
treatments.
Then,
changes
viability,
reactive
oxygen
species
(ROS)
tumor
necrosis
factor
alpha
(TNF-α)
levels
were
measured
response
treatment
quercetin,
luteolin
GSOP
at
25
50
μg/mL
concentrations.
We
found
ROS
significantly
lower
groups
by
flavonoid
same
time
compared
LPS-treated
groups,
whereas
TNF-α
reduced
only
treatment.
contrast,
concentrations
caused
an
increase
levels,
while
higher
significant
decrease.
results
suggest
use
be
helpful
management
intestinal
barrier
integrity
or
altered
composition,
mitigation
inflammatory
processes
maintained
endotoxemia.
Further
vitro
vivo
studies
needed
before
clinical
use.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 614 - 614
Опубликована: Янв. 13, 2025
The
complex
relationship
between
diet,
the
gut
microbiota,
and
mental
health,
particularly
depression,
has
become
a
focal
point
of
contemporary
research.
This
critical
review
examines
how
specific
dietary
components,
such
as
fiber,
proteins,
fats,
vitamins,
minerals,
bioactive
compounds,
shape
microbiome
influence
microbial
metabolism
in
order
to
regulate
depressive
outcomes.
These
dietary-induced
changes
microbiota
can
modulate
production
metabolites,
which
play
vital
roles
gut–brain
communication.
axis
facilitates
this
communication
through
neural,
immune,
endocrine
pathways.
Alterations
metabolites
central
nervous
system
(CNS)
functions
by
impacting
neuroplasticity,
inflammatory
responses,
neurotransmitter
levels—all
are
linked
onset
course
depression.
highlights
recent
findings
linking
components
with
beneficial
composition
reduced
symptoms.
We
also
explore
challenges
individual
variability
responses
interventions
long-term
sustainability
these
strategies.
underscores
necessity
for
further
longitudinal
mechanistic
studies
elucidate
precise
mechanisms
diet
interactions
be
leveraged
mitigate
paving
way
personalized
nutritional
therapies.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(9), С. 4769 - 4769
Опубликована: Апрель 27, 2024
Contemporary
living
is
continuously
leading
to
poor
everyday
choices
resulting
in
the
manifestation
of
various
diseases.
The
benefits
plant-based
nutrition
are
undeniable
and
research
on
topic
rising.
Modern
man
now
aware
possibilities
that
plant
can
provide
seeking
ways
benefit
from
it.
Dietary
phenolic
compounds
among
easily
accessible
beneficial
substances
exhibit
antioxidant,
anti-inflammatory,
antitumor,
antibacterial,
antiviral,
antifungal,
antiparasitic,
analgesic,
anti-diabetic,
anti-atherogenic,
antiproliferative,
as
well
cardio-and
neuroprotective
activities.
Several
industries
exploring
incorporate
biologically
active
their
produce.
This
review
concentrated
presenting
current
information
about
dietary
contribution
maintaining
good
health.
Additionally,
this
content
will
demonstrate
importance
prosperity
natural
for
fields,
i.e.,
food
industry,
cosmetology,
biotechnology,
others.
Nutrition & Metabolism,
Год журнала:
2024,
Номер
21(1)
Опубликована: Июль 18, 2024
Abstract
Background
Natural
compounds
can
positively
impact
health,
and
various
studies
suggest
that
they
regulate
glucose‒lipid
metabolism
by
influencing
short-chain
fatty
acids
(SCFAs).
This
is
key
to
maintaining
energy
balance
normal
physiological
functions
in
the
body.
review
explores
how
SCFAs
glucose
lipid
natural
modulate
these
processes
through
SCFAs.
provides
a
healthier
approach
treating
disorders
future.
Methods
article
reviews
relevant
literature
on
glycolipid
from
PubMed
Web
of
Science
Core
Collection
(WoSCC).
It
also
highlights
range
compounds,
including
polysaccharides,
anthocyanins,
quercetins,
resveratrols,
carotenoids,
betaines,
modulation
SCFA
pathway.
Results
enrich
SCFA-producing
bacteria,
inhibit
harmful
operational
taxonomic
unit
(OTU)
abundance
intestinal
transport
rate
gut
microbiota
affect
content
intestine.
However,
most
have
been
conducted
animals,
lack
clinical
trials,
involve
fewer
target
More
research
needed
support
conclusions
develop
interventions.
Conclusions
are
crucial
for
human
health
produced
mainly
via
dietary
fiber
fermentation.
Eating
foods
rich
fruits,
vegetables,
tea,
coarse
foods,
hinder
bacterial
growth
promote
beneficial
proliferation,
thus
increasing
levels
regulating
metabolism.
By
investigating
pathway,
novel
insights
directions
glucolipid
be
provided.
Microbial Biotechnology,
Год журнала:
2025,
Номер
18(3)
Опубликована: Март 1, 2025
ABSTRACT
Advances
in
neuromicrobiology
and
related
omics
technologies
have
reinforced
the
idea
that
unseen
microbes
play
critical
roles
human
cognition
behaviour.
Included
this
research
is
evidence
indicating
gut
microbes,
through
direct
indirect
pathways,
can
influence
aggression,
anger,
irritability
antisocial
Moreover,
manufacture
chemicals
are
known
to
compromise
cognition.
For
example,
recent
court
decisions
United
States
Europe
acknowledge
produce
high
levels
of
ethanol,
without
consumption
alcohol
by
defendants.
The
dismissal
driving
while
intoxicated
charges
these
cases—so‐called
auto‐brewery
syndrome—highlights
way
which
microbiome
knowledge
will
enhance
precision,
objectivity
fairness
our
legal
systems.
Here
opinion
essay,
we
introduce
concept
‘legalome’—the
application
science
forensic
psychiatry
criminal
law.
We
argue
rapid
pace
microbial
discoveries,
including
those
challenge
ideas
free
moral
responsibility,
necessitate
a
reconsideration
traditional
doctrines
justifications
retributive
punishment.
implications
extend
beyond
courtroom,
challenging
us
reconsider
how
environmental
factors—from
diet
socioeconomic
conditions—might
shape
preventative
rehabilitative
efforts
their
effects
on
microbiome.
