Flavonoids with Anti-Angiogenesis Function in Cancer

Molecules, Год журнала: 2024, Номер 29(7), С. 1570 - 1570

Опубликована: Март 31, 2024

The formation of new blood vessels, known as angiogenesis, significantly impacts the development multiple types cancer. Consequently, researchers have focused on targeting this process to prevent and treat numerous disorders. However, most existing anti-angiogenic treatments rely synthetic compounds humanized monoclonal antibodies, often expensive or toxic, restricting patient access these therapies. Hence, pursuit discovering new, affordable, less efficient is imperative. Numerous studies propose that natural plant-derived products exhibit sought-after characteristics. objective review delve into properties exhibited by naturally derived flavonoids from plants, along with their underlying molecular mechanisms action. Additionally, we summarize structure, classification, relationship between signaling pathways in plants agents, including main HIF-1α/VEGF/VEGFR2/PI3K/AKT, Wnt/β-catenin, JNK1/STAT3, MAPK/AP-1 pathways. Nonetheless, further research innovative approaches are required enhance bioavailability for clinical application.

Язык: Английский

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Anti-inflammatory activity of flavonols via inhibiting MAPK and NF-κB signaling pathways in RAW264.7 macrophages

Current Research in Food Science, Год журнала: 2022, Номер 5, С. 1176 - 1184

Опубликована: Янв. 1, 2022

Fisetin (Fis), quercetin (Que), and myricetin (Myr) are flavonols with similar structure but different number of hydroxyl groups. The present research focused on the anti-inflammatory effect these three in lipopolysaccharide-stimulated RAW264.7 cells. site group obviously affected their anti-inflammation activity. These suppressed overproduction nitric oxide. Fis showed best activity an inhibition rate 52% at 20 μM. Moreover, reduced levels ROS, TNF-α, IL-6. mechanistic study that they inhibited activation NF-κB MAPK pathways by suppressing phosphorylation IκBα, p65, JNK, ERK, p38, MEK, reducing nuclear translocation p65. In addition, metabolism was examined. results indicated both methylated glucuronidated. Que Myr were mainly transformed into products. This highlights flavonols, particularly Fis, which has potential for prevention or treatment inflammation as adjuvant medicine food additive.

Язык: Английский

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Coumarins and flavones from Ficus erecta and their anti-inflammatory activity

Journal of Ethnopharmacology, Год журнала: 2024, Номер 333, С. 118472 - 118472

Опубликована: Июнь 19, 2024

Ficus erecta, a traditional Chinese She Ethnomedicine, has been historically utilized to treat various inflammatory conditions such as arthritis, nephritis, and osteoporosis. However, the underlying mechanisms accounting for its anti-inflammatory activity, well active components, largely remain elusive. The purpose of this research was investigate chemical constituents F. erecta that contribute effects. Coumarins flavones were obtained from 95% EtOH extract using virous column chromatography reversed-phase semipreparative HPLC. structures new compounds elucidated by extensive analysis spectroscopic methods, including HRESIMS, 1D 2D NMR spectra, CD experiments. Cultured macrophage RAW264.7 cells MTT cell viability assay, Griess reagent method, ELISA, Western blot experiments employed evaluate activity related mechanism. Four (1–4) eleven previously identified (5–16) coumarins, together with one (17) six known (18–23) isolated whole plant erecta. Compounds 7 17 significantly reduced nitric oxide (NO) prostaglandin E2 (PGE2) production without cytotoxic Furthermore, proinflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 in concentration-dependent manner. indicated suppressed expression iNOS, COX-2, p-IκBα LPS-stimulated cells. current phytochemical investigations revealed coumarins represent primary exhibit potent properties, linked inhibition NF-κB activation preventing degradation IκBα phosphorylation. These may serve promising candidates treating or certain diseases.

Язык: Английский

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Pharmacological Activities of Lonicerae japonicae flos and Its Derivative—“Chrysoeriol” in Skin Diseases

Molecules, Год журнала: 2024, Номер 29(9), С. 1972 - 1972

Опубликована: Апрель 25, 2024

Chrysoeriol is an active ingredient derived from the Chinese medicinal herb (CMH) “Lonicerae japonicae flos” in dried flower bud or bloomed of Lonicera japonica Thunberg. Dermatoses are most common diseases humans, including eczema, acne, psoriasis, moles, and fungal infections, which temporary permanent may be painless painful. Topical corticosteroids widely used Western medicine, but there some side effects when it continuously regularly utilized a large dosage. natural ingredient, nontoxic, without any adverse reactions treatment dermatological conditions. Methods: Nine electronic databases were searched, WanFang Data, PubMed, Science Direct, Scopus, Web Science, Springer Link, SciFinder, China National Knowledge Infrastructure (CNKI), regard to language constraints. The pharmacological activities chrysoeriol Lonicerae flos fight against skin explained evaluated through literature review either vitro vivo studies. Results: decreased mRNA levels proinflammatory cytokines IL-6, IL-1β, TNF-α. These transcriptionally regulated by NF-κB STAT3 combat inflammation. It also showed promising actions treating many ailments wound healing, depigmentation, photoprotection, antiaging. Conclusion: cutaneous route best delivery approach across barrier. However, toxicity, dosage, safety assessments formulation nanochrysoeriol on human epidermis for application must further investigated.

Язык: Английский

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A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders

Phytotherapy Research, Год журнала: 2024, Номер 38(8), С. 4202 - 4229

Опубликована: Июнь 26, 2024

Abstract Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by glucose and lipid disorders with diverse etiology rapidly increasing incidence. Many studies have identified the role of flavonoids in ameliorating GLMD, mechanisms related to peroxisome proliferator‐activated receptors, nuclear factor kappa‐B, AMP‐activated protein kinase, (erythroid‐derived 2)‐like 2, transporter type 4, phosphatidylinositol‐3‐kinase/protein kinase B pathway. However, comprehensive summary flavonoid effects on GLMD lacking. This study reviewed roles natural different structures treatment reported globally past 5 years provides reference for developing as drugs treating GLMD.

Язык: Английский

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Chemical composition and antibacterial activity of 12 medicinal plant ethyl acetate extracts using LC–MS feature‐based molecular networking

Phytochemical Analysis, Год журнала: 2022, Номер 33(3), С. 473 - 489

Опубликована: Янв. 18, 2022

Widespread use of antibiotics has led to an increase in bacterial multiple drug resistance, thereby searching for natural antimicrobial agents from plants becomes effective and alternative approach. In the present study, we selected six foodborne bacteria evaluate antibacterial activities 12 medicinal ethyl acetate (EA) extracts.This study aims search antibiotic substitutes plant extracts. The components were further discussed through chemometric mass spectroscopic analyses.Agar well diffusion microdilution methods used test activity. Total phenolic content (TPC) total flavonoid (TFC) judge active phytochemicals. To characterise potential components, ultra-performance liquid chromatography-quadrupole-time flight-mass spectrometry (UPLC-Q-TOF-MS) coupled with Pearson correlation feature-based molecular network (FBMN) proposed.Most extracts possessed activity against Bacillus subtilis Salmonella typhi. Toona sinensis shoots Firmiana simplex barks showed high inhibitory Staphylococcus aureus, Shigella dysenteriae, Escherichia coli strains minimum concentrations (MICs) 1.56, 0.78, 0.39 mg/mL, respectively. typhi was highly sensitive diameter up 21.67 ± 0.95 mm, MIC at 0.78 mg/mL. Moreover, had highest TPCs.Our results indicated that shoots, Koelreuteria paniculate seeds, could be supplied as sources agents. Furthermore, 36 bioactive compounds identified mainly polyphenols, glycosides, terpenoids.

Язык: Английский

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Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation and blocking metabolic reprogramming

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Май 12, 2023

Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents control inflammation have limited long-term use potential due various side-effects. This study aimed examine the preventive effects norbergenin, constituent traditional anti-inflammatory recipes, on LPS-induced proinflammatory signaling in macrophages elucidate underlying mechanisms by integrative metabolomics shotgun label-free quantitative proteomics platforms. Using high-resolution mass spectrometry, we identified quantified nearly 3000 proteins across all samples each dataset. To interpret these datasets, exploited differentially expressed conducted statistical analyses. Accordingly, found that production NO, IL1β, TNFα, IL6 iNOS was alleviated norbergenin via suppressed activation TLR2 mediated NFκB, MAPKs STAT3 pathways. In addition, capable overcoming LPS-triggered metabolic reprogramming restrained facilitated glycolysis, promoted OXPHOS, restored aberrant metabolites within TCA cycle. linked its modulation enzymes support activity. Thus, our results uncover regulates inflammatory cascades LPS stimulated exert potential.

Язык: Английский

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What We Know about Euterpe Genus and Neuroprotection: A Scoping Review

Nutrients, Год журнала: 2023, Номер 15(14), С. 3189 - 3189

Опубликована: Июль 19, 2023

The Euterpe genus (mainly oleracea Martius, precatoria and edulis Martius) has recently gained commercial scientific notoriety due to the high nutritional value of its fruits, which are rich in polyphenols (phenolic acids anthocyanins) have potent antioxidant activity. These characteristics contributed increased number neuropharmacological evaluations three species over last 10 years, especially açaí Martius. fruits exert neuroprotective effects through modulation inflammatory oxidative pathways other mechanisms, including inhibition mTOR pathway protection blood–brain barrier, all them intimately involved several neuropathologies. Thus, a better understanding properties these may open new paths for development therapeutic tools aimed at preventing treating variety neurological conditions.

Язык: Английский

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Integrated omics analysis reveals the alteration of gut microbiota and fecal metabolites in Cervus elaphus kansuensis

Applied Microbiology and Biotechnology, Год журнала: 2024, Номер 108(1), С. 1 - 22

Опубликована: Янв. 15, 2024

Abstract The gut microbiota is the largest and most complex microecosystem in animals. It influenced by host’s dietary habits living environment, its composition diversity play irreplaceable roles animal nutrient metabolism, immunity, adaptation to environment. Although of red deer has been studied, function Gansu ( Cervus elaphus kansuensis ), an endemic subspecies China, not reported. In this study, microbiome fecal metabolomics C. were identified compared for first time using 16S rDNA sequencing, metagenomic LC-MS/MS. There significant differences structure between wild farmed . sequencing results showed that genus UCRD-005 was dominant both captive (CRD) (WRD). Metagenomic similar those CRD WRD at phylum levels. metagenomics data suggested Bacteroides Bacillus might serve as marker genera WRD, respectively. Fecal 520 metabolites with detected differential involved lipid metabolism. large indicating different environments over have led development stable characteristics meet their respective survival reproduction needs. Key points • Environment food affected Genera may important respectively Flavonoids ascorbic acid influence health

Язык: Английский

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Effects of luteolin supplementation on growth, histology, antioxidant capacity, non−specific immunity and intestinal microbiota of the red swamp crayfish (Procambarus clarkii)

Animal Feed Science and Technology, Год журнала: 2024, Номер 313, С. 115986 - 115986

Опубликована: Май 7, 2024

Язык: Английский

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