Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июнь 24, 2022

Parkinson’s disease (PD) is the second most common neurodegenerative characterized by motor dysfunction. Growing evidence has demonstrated that gut dysbiosis involved in occurrence, development and progression of PD. Numerous clinical trials have identified characteristics changed microbiota profiles, preclinical studies PD animal models indicated can influence onset via increasing intestinal permeability, aggravating neuroinflammation, aggregating abnormal levels α-synuclein fibrils, oxidative stress, decreasing neurotransmitter production. The be considered promising diagnostic therapeutic targets for PD, which regulated probiotics, psychobiotics, prebiotics, synbiotics, postbiotics, fecal transplantation, diet modifications, Chinese medicine. This review summarizes recent PD-associated profiles functions, potential roles, mechanisms microbiota-targeted interventions Deciphering underlying roles will help interpret pathogenesis from new perspectives elucidate novel strategies

Язык: Английский

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A novel approach to Lactiplantibacillus plantarum: From probiotic properties to the omics insights

Microbiological Research, Год журнала: 2022, Номер 268, С. 127289 - 127289

Опубликована: Дек. 22, 2022

Lactiplantibacillus plantarum (previously known as Lactobacillus plantarum) strains are one of the lactic acid bacteria (LAB) commonly used in fermentation and their probiotic functional properties along with health-promoting roles come to fore. Food-derived L. have shown good resistance adhesion gastrointestinal tract (GI) excellent antioxidant antimicrobial properties. Furthermore, many can produce bacteriocins interesting activity. This existing different niches give a great potential beneficial effects on health. It is also has been that regulate intestinal microbiota composition way. Recently, omics approaches such metabolomics, secretomics, proteomics, transcriptomics genomics try understand mechanisms related its characteristics. review provides an overview properties, including specific interactions between host, insights plantarum.

Язык: Английский

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Gut Microbiota Modulates Neurotransmitter and Gut-Brain Signaling

Microbiological Research, Год журнала: 2024, Номер 287, С. 127858 - 127858

Опубликована: Июль 26, 2024

Язык: Английский

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Probiotic significance of Lactobacillus strains: a comprehensive review on health impacts, research gaps, and future prospects

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Ноя. 24, 2024

A rising corpus of research has shown the beneficial effects probiotic

Язык: Английский

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Gastrodia elata polysaccharide alleviates Parkinson's disease via inhibiting apoptotic and inflammatory signaling pathways and modulating the gut microbiota

Food & Function, Год журнала: 2024, Номер 15(6), С. 2920 - 2938

Опубликована: Янв. 1, 2024

Gastrodia elata polysaccharide significantly alleviated motor dysfunction, inhibited α-synuclein accumulation in PD mice via inhibiting apoptotic and inflammatory signaling pathways modulating the gut microbiota.

Язык: Английский

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Lactiplantibacillus (Lactobacillus) plantarum as a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 3010 - 3010

Опубликована: Март 5, 2024

This systematic review addresses the use of Lactiplantibacillus (Lactobacillus) plantarum in symptomatological intervention neurodegenerative disease. The existence gut microbiota dysbiosis has been associated with systemic inflammatory processes present disease, creating opportunity for new treatment strategies. involves modifying strains that constitute to enhance synaptic function through gut–brain axis. Recent studies have evaluated beneficial effects on motor and cognitive symptomatology, alone or combination. includes 20 research articles (n = 3 human n 17 animal models). main result this was combination produced improvements symptomatology related However, one included reported negative after administration plantarum. provides current relevant information about probiotic pathologies such as Alzheimer’s Parkinson’s disease Multiple Sclerosis.

Язык: Английский

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Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability

Immunity & Ageing, Год журнала: 2024, Номер 21(1)

Опубликована: Янв. 2, 2024

Parkinson's disease (PD), a neurodegenerative disorder with an unknown etiology, is primarily characterized by the degeneration of dopamine (DA) neurons. The prevalence PD has experienced significant surge in recent years. unidentified etiology poses limitations to development effective therapeutic interventions for this condition. Helicobacter pylori (H. pylori) infection affected approximately half global population. Mounting evidences suggest that H. plays important role through various mechanisms. autotoxin produced induces pro-inflammatory cytokines release, thereby facilitating occurrence central inflammation leads neuronal damage. Simultaneously, disrupts equilibrium gastrointestinal microbiota overgrowth bacteria small intestinal known as bacterial (SIBO). This dysbiosis gut flora influences nervous system (CNS) microbiome-gut-brain axis. Moreover, SIBO hampers levodopa absorption and affects its efficacy treatment PD. Also, promotes production defensins regulate permeability blood-brain barrier, entry harmful factors into CNS. In addition, been found induce gastroparesis, resulting prolonged transit time reach intestine. may exploit facilitate own growth proliferation, or it can inflict damage mucosa, leading ulcers impeding absorption. Here, review focused on from pathogenesis bioavailability.

Язык: Английский

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Dynamics of Changes in the Gut Microbiota of Healthy Mice Fed with Lactic Acid Bacteria and Bifidobacteria

Microorganisms, Год журнала: 2022, Номер 10(5), С. 1020 - 1020

Опубликована: Май 12, 2022

Probiotics are living microorganisms that provide numerous health benefits for their host. have various effects on the body; example, they change gut microbiota, improve integrity of epithelial barrier and anti-inflammatory effects. The use probiotic supplements based lactic acid bacteria bifidobacteria is one approaches used to balance microflora. In our study, we evaluated supplements, which were members Lactobacillaceae family bifidobacteria, microbiome healthy mice using 16S rRNA sequencing method. data obtained demonstrated when received statistically significant changes occurred in composition at phylum level, characterized by an increase number Actinobacteriota, Bacteroidota, Verrucomicrobia Proteobacteria, all potentially positive health. At generic a decrease abundance Nocardioides, Helicobacter Mucispirillum genus, involved inflammatory processes, was observed group fed with bacteria. For seen Tyzzerella Akkermansia genus. results study contribute understanding microbiota under influence probiotics. It shown probiotics more effect than bifidobacteria.

Язык: Английский

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The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(20), С. 12289 - 12289

Опубликована: Окт. 14, 2022

The bidirectional interaction between the gut microbiota (GM) and Central Nervous System, so-called brain axis (GMBA), deeply affects function has an important impact on development of neurodegenerative diseases. In Parkinson’s disease (PD), gastrointestinal symptoms often precede onset motor non-motor manifestations, alterations in GM composition accompany pathogenesis. Several studies have been conducted to unravel role dysbiosis intestinal permeability PD progression, but therapeutic diagnostic applications modifying approaches remain be fully elucidated. After a brief introduction involvement GMBA disease, we present evidence for leaky patients. According these data, then review potential GM-based signatures serve as biomarkers highlight emerging probiotics, prebiotics, antibiotics, dietary interventions, fecal transplantation supportive PD. Finally, analyze mutual influence commonly prescribed medications gut-microbiota, offer insights also nasal oral pathology, thus providing comprehensive up-to-date overview microbial features diagnosis treatment.

Язык: Английский

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Neuroprotective Effects of Bifidobacterium breve CCFM1067 in MPTP-Induced Mouse Models of Parkinson’s Disease

Nutrients, Год журнала: 2022, Номер 14(21), С. 4678 - 4678

Опубликована: Ноя. 4, 2022

There is mounting evidence that the microbiota-gut-brain axis (MGBA) critical in pathogenesis and progression of Parkinson's disease (PD), suggesting probiotic therapy restoring gut microecology may slow down progression. In this study, we examined disease-alleviating effects Bifidobacterium breve CCFM1067, orally administered for 5 weeks a PD mouse model. Our study shows supplementation with B. CCFM1067 protected dopaminergic neurons suppressed glial cell hyperactivation neuroinflammation mice. addition, antioxidant capacity central nervous system was enhanced oxidative stress alleviated. Moreover, blood-brain intestinal barriers from damage MPTP-induced The results fecal microbiota analysis showed intervention could act on microecological imbalance microbiota, suppressing number pathogenic bacteria (Escherichia-Shigella) while increasing beneficial (Bifidobacterium Akkermansia) increase short chain fatty acids (acetic butyric acids) explain anti-inflammatory action or brain conclusion, demonstrated which can prevent treat by modulating gut-brain axis, be utilized as possible new oral supplement therapy.

Язык: Английский

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