International Journal of Biological Macromolecules, Год журнала: 2024, Номер 283, С. 137373 - 137373
Опубликована: Ноя. 7, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 297, С. 139875 - 139875
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
1
Journal of Ethnopharmacology, Год журнала: 2024, Номер 328, С. 118064 - 118064
Опубликована: Март 21, 2024
Язык: Английский
Процитировано
6
Frontiers in Nutrition, Год журнала: 2025, Номер 12
Опубликована: Янв. 31, 2025
Neurological disorders pose significant global public health challenges, with a rising prevalence and complex pathophysiological mechanisms that impose substantial social economic burdens. Traditional Chinese Medicine (TCM), its holistic approach multi-target effects, has gained increasing attention in the treatment of neurological diseases. This review explores bioactive compounds derived from herbal plants, focusing on their action, underlying pathways, potential applications functional food development. The highlights neuroprotective properties flavonoids, alkaloids, polysaccharides, polyphenols found key TCM herbs such as Scutellaria baicalensis , Salvia miltiorrhiza Ligusticum chuanxiong Gastrodia elata . These have demonstrated anti-inflammatory, antioxidant, neurogenic making them promising candidates for prevention conditions, including Alzheimer’s disease (AD), Parkinson’s (PD), depression. Furthermore, synergistic effects formulations targeting multiple signaling pathways offer advantages over single-target therapies, especially combating neurodegenerative also discusses challenges future directions integrating these into foods dietary supplements, aiming to improve enhance clinical outcomes. Ultimately, this work aims provide valuable insights TCM-based interventions promoting well-being addressing burden disorders.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141781 - 141781
Опубликована: Март 1, 2025
We here extracted a polysaccharide fragment from Gastrodia elata, characterized by main chain connected via (1 → 4)-α-D-Glcp bonds, with terminal α-D-Glcp-(1→) linked to the through O-6 of 4,6)-α-D-Glcp and O-3 3,4)-α-D-Glcp (SRGP). Both in vitro vivo experiments demonstrated that SRGP activates TLR4/NF-κB signaling pathway, exerting immunomodulatory effects alleviating cyclophosphamide (CTX)-induced intestinal mucosal damage mice. High-throughput 16S rRNA sequencing further revealed restores gut microbiota composition enhances abundance specific bacterial populations. Additionally, improves CTX-induced upregulating tight junction proteins, mitigating dysbiosis, regulating both overall microbial community levels bacteria.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 277, С. 134303 - 134303
Опубликована: Июль 29, 2024
Язык: Английский
Процитировано
4
Food & medicine homology., Год журнала: 2024, Номер 2(2), С. 9420033 - 9420033
Опубликована: Сен. 4, 2024
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136691 - 136691
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
4
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11629 - 11629
Опубликована: Окт. 29, 2024
Parkinson's disease (PD) is a complex neurodegenerative disorder. Recent evidence reveals connections between neuroinflammatory processes and intestinal microbiota alterations in the progression of this pathology. This comprehensive review explores intricate relationships them, highlighting their combined impact on PD. Neuroinflammation, characterized by immune activation central nervous system, increasingly acknowledged as critical factor development Concurrently, gut composition have been linked to PD, suggesting potential modulatory role progression. Thus, bidirectional communication along gut-brain axis has become pivotal comprehending pathogenesis Furthermore, we explore emerging therapeutic strategies that target these interconnected pathways, providing insights into avenues for PD treatment. The elucidation establishes promising foundation innovative aimed at altering improving quality life individuals affected
Язык: Английский
Процитировано
4
Molecules, Год журнала: 2025, Номер 30(2), С. 262 - 262
Опубликована: Янв. 10, 2025
Gastrodia elata Blume is a well-known medicinal and edible plant in China, celebrated for its extensive history traditional medicine functional food applications. Among key bioactive components, polysaccharides have drawn significant attention from researchers the fields of health due to their potential benefits. Recent studies revealed various biological activities associated with G. polysaccharides, including antioxidant, anti-tumor, anti-inflammatory, antibacterial, anti-aging, immune regulation, neuroprotective properties. However, comprehensive overview these remains elusive. Specifically, relationship between structure activity along mechanisms through which types exert effects, has yet be fully elucidated. This knowledge gap may impede further development utilization medicine, products, food, cosmetics. paper provides recent advancements extraction, separation, purification, activities, applications polysaccharides. Additionally, it delves into structure-activity relationships pharmacological giving support future research enhance application
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140084 - 140084
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0