Genetic variation of drug target CYP51 conferring resistance to ergosterol biosynthesis inhibitors in Botrytis cinerea, causing lily gray mould

Industrial Crops and Products, Год журнала: 2023, Номер 208, С. 117797 - 117797

Опубликована: Ноя. 16, 2023

Язык: Английский

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Synthesis, antifungal activity, and 3d-QSAR study of L- carvone-based pyrazole-oxime ester compounds

Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 10

Опубликована: Сен. 16, 2024

Natural products can provide versatile substructures with potential bioactivity and biocompatibility for exploring bioactive compounds. Herein, to explore novel natural product-derived antifungal agents, 21 unreported

Язык: Английский

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Synthesis, crystal structure and fungicidal activities of 3-(Trifluoromethyl)-Pyrazole-4-carboxylic oxime ester derivatives

Journal of Molecular Structure, Год журнала: 2022, Номер 1265, С. 133405 - 133405

Опубликована: Май 29, 2022

Язык: Английский

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Synthesis, Structural Determination, and Antifungal Activity of Novel Fluorinated Quinoline Analogs

Molecules, Год журнала: 2023, Номер 28(8), С. 3373 - 3373

Опубликована: Апрель 11, 2023

A series of new fluorinated quinoline analogs were synthesized using Tebufloquin as the lead compound, 2-fluoroaniline, ethyl 2-methylacetoacetate, and substituted benzoic acid raw materials. Their structures confirmed by 1H NMR, 13C HRMS. The compound 8-fluoro-2,3-dimethylquinolin-4-yl 4-(tert-butyl)benzoate (2b) was further determined X-ray single-crystal diffraction. antifungal activity tested at 50 μg/mL, bioassay results showed that these derivatives had good activity. Among them, compounds 2b, 2e, 2f, 2k, 2n exhibited (>80%) against S. sclerotiorum, 2g displayed (80.8%) R. solani.

Язык: Английский

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Synthesis, crystal structure, herbicidal activity and mode of action of new cyclopropane-1,1-dicarboxylic acid analogues

Pesticide Biochemistry and Physiology, Год журнала: 2022, Номер 188, С. 105228 - 105228

Опубликована: Сен. 14, 2022

Язык: Английский

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Design, Synthesis, and Herbicidal Activity of Naphthalimide–Aroyl Hybrids as Potent Transketolase Inhibitors

Journal of Agricultural and Food Chemistry, Год журнала: 2022, Номер 70(40), С. 12819 - 12829

Опубликована: Сен. 29, 2022

Transketolase (TK) was identified as a new target for the development of novel herbicides. In this study, series naphthalimide-aroyl hybrids were designed and prepared based on TK tested their herbicidal activities. vitro bioassay showed that compounds 4c 4w exhibited stronger inhibitory effects against Digitaria sanguinalis (DS) Amaranthus retroflexus (AR) with inhibition over 90% at 200 mg/L around 80% 100 mg/L. Also, excellent postemergence activity DS AR 90 g [active ingredient (ai)]/ha 50 (ai)/ha in greenhouse, which comparable mesotrione. The fluorescent quenching experiments At revealed occurrence electron transfer from compound to formation strong exciplex between them. Molecular docking analyses further profound affinity through interaction amino acids active site, results its activities TK. These findings demonstrated is potentially lead candidate herbicides targeting

Язык: Английский

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Synthesis, crystal structure and antifungal activities of new quinoline derivatives

Journal of Molecular Structure, Год журнала: 2022, Номер 1277, С. 134792 - 134792

Опубликована: Дек. 13, 2022

Язык: Английский

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Preparation of a novel glucose oxidase-N-succinyl chitosan nanospheres and its antifungal mechanism of action against Colletotrichum gloeosporioides

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 228, С. 681 - 691

Опубликована: Дек. 19, 2022

Язык: Английский

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Design, Synthesis, and Biological Activity Studies of Myricetin Derivatives Containing a Diisopropanolamine Structure

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(45), С. 25034 - 25044

Опубликована: Ноя. 5, 2024

A series of myricetin derivatives containing diisopropanolamine were designed and synthesized. The in vitro inhibitory effects the target compounds on 9 fungal pathogens 3 bacterial also evaluated. A12 had best effect against Xanthomonas oryzae pv. (Xoo), with an EC50 value 4.9 μg/mL, which was better than zinc–thiazole (ZT: = 7.3 μg/mL) thiodiazole–copper (TC: 65.5 μg/mL); A25 Phomopsis sp. (Ps), 17.2 azoxystrobin (Az: 22.3 μg/mL). In vivo inhibition tests performed kiwifruit for rice leaves A12. At 200 curative activity leaf blight 40.7%, that ZT (37.2%) TC (32.9%), protective 44.8%, (39.5%) (34.6%). kiwi soft rot disease 70.1%, Az (62.8%). Preliminary elucidation possible mechanisms action carried out by experiments fluorescence microscopy, scanning electron formation biofilms, density functional theory calculations, so on.

Язык: Английский

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Antifungal activity of chalcone derivatives containing 1,2,3,4‐tetrahydroquinoline and studies on them as potential SDH inhibitors

Pest Management Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

A large number of pathogenic fungi have caused serious damage to the global crop yield, and drug resistance is always a topic that cannot be avoided for traditional fungicides. Therefore, finding efficient, green, low-toxic fungicides our primary task, which brings opportunities development natural product green pesticides.

Язык: Английский

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