Medicine,
Год журнала:
2023,
Номер
102(49), С. e36457 - e36457
Опубликована: Дек. 8, 2023
To
discuss
the
early
changes
of
Glu
and
Cho
in
affected
areas
different
types
subjective
cognitive
decline,
including
amnestic
MCI
(aMCl),
non-amnestic
(naMCI)
vascular
impairment
no
dementia
(VCIND),
using
Proton
Magnetic
Resonance
Spectroscopy
(
1
H-MRS)
technology.
Routine
head
MRI
l
H-MRS
examinations
were
performed
on
50
clearly
diagnosed
aMCI
patients,
44
naMCI
VCIND
elderly
individuals
with
normal
function.
Measure
volume
patient
bilateral
hippocampus.
Using
hippocampus,
left
posterior
cingulate
gyrus
(PCG),
frontal
lobe
as
regions
interest,
scope
under
peak
N-acetylaspartate
(NAA),
choline
complex
(Cho),
glutamate
(Glu),
Metabolic
Images
(mI),
creatine
(Cr)
was
tested.
Perform
a
correlation
analysis
between
NAA/Cho/Cr
values
group
MoCA
score.
All
experimental
subjects
right-handed.
The
NAACr
both
hippocampus
greatly
lower
than
those
control
P
<
.05).
NAA/Cr
sides
correlated
score
(P
LHp
PCG
groups
NC
showed
obvious
decrease
compared
to
NC.
Glu/Cr
discrepancy
>
.05.
In
lobe,
contrast
NC,
mI/Cr
higher
relative
concentration
1H-MRS
metabolites
can
indicate
presence
hippocampal
neuronal
damage
before
morphological
occur
reflect
function
patients
certain
extent.
There
are
regional
differences
mI
metabolism
brain
groups.
provides
an
effective
basis
for
clinical
differentiation
naMCI.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Янв. 8, 2024
Alzheimer's,
Parkinson's,
and
dementia
are
the
leading
neurodegenerative
diseases
that
threaten
world
with
aging
population.
Although
pathophysiology
of
each
disease
is
unique,
steps
to
be
taken
prevent
similar.
One
changes
a
person
can
make
alone
gain
habit
an
antioxidant-rich
diet.
Phytochemicals
known
for
their
antioxidant
properties
have
been
reported
in
various
studies.
similar
chemical
structures
grouped.
Accordingly,
there
two
main
groups
phytochemicals,
flavonoid
non-flavonoid.
Various
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
Black
phosphorus
(BP),
as
a
representative
metal-free
semiconductor,
has
been
extensively
explored.
It
higher
drug
loading
capacity
in
comparison
to
conventional
materials
and
also
possesses
excellent
biocompatibility
biodegradability.
Furthermore,
BP
nanosheets
can
enhance
the
permeability
of
blood–brain
barrier
(BBB)
upon
near-infrared
(NIR)
irradiation,
owing
their
photothermal
effect.
However,
inherent
instability
poses
significant
limitation,
highlighting
importance
surface
modification
its
stability.
Ischemic
stroke
(IS)
is
caused
by
occlusion
blood
vessels,
treatment
challenging
due
hindrance
BBB.
Therefore,
there
an
urgent
need
identify
improved
methods
for
bypassing
BBB
more
efficient
IS
treatment.
This
research
devised
novel
delivery
approach
based
on
pterostilbene
(Pte)
supported
nanosheets,
modified
with
polydopamine
(PDA)
form
BP-Pte@PDA.
system
shows
robust
stability
traverses
using
effective
mechanisms.
enables
release
Pte
pH
NIR
stimuli,
offering
potential
therapeutic
advantages
treating
IS.
In
middle
cerebral
artery
mouse
model,
BP-Pte@PDA
significantly
reduced
infarct
size,
brain
water
content,
neurological
deficits,
TLR4
inflammatory
factor
expression,
inhibited
cell
apoptosis.
summary,
fabricated
this
study
thus
demonstrated
good
stability,
efficacy,
biocompatibility,
rendering
it
suitable
clinical
application.
As
a
pattern
recognition
receptor,
Toll-like
receptor
4
(TLR4)
is
crucial
for
the
development
and
progression
of
acute
kidney
injury
(AKI).
This
study
aims
to
explore
whether
deubiquitinase
Usp9x
influences
TLR4/NF-B
pathway
cause
sepsis-induced
(S-AKI).
The
model
AKI
was
established
in
Sprague-Dawley
rats
using
cecal
ligation
puncture
(CLP)
method,
while
renal
tubular
epithelial
cell
NRK-52E
stimulated
with
lipopolysaccharide
(LPS)
vitro.
All
plasmids
were
transfected
into
cells
according
indicated
group.
TLR4
predicted
by
online
prediction
software
Ubibrowser.
Subsequently,
Western
blot
Pearson
correlation
analysis
identified
protein
as
potential
candidate.
Co-IP
verified
interaction
between
Usp9x.
Further
research
revealed
that
overexpression
inhibited
degradation
downregulating
its
ubiquitination
modification
levels.
Both
vivo
vitro
experiments
observed
interference
effectively
alleviated
inflammatory
response
apoptosis
(RTECs)
induced
CLP
or
LPS,
whereas
reversed
this
situation.
Transfection
sh-Usp9x
suppressed
expression
proteins
associated
TLR4/NF-κB
LPS.
Moreover,
effect
transfection.
Therefore,
interacts
TLR4,
leading
upregulation
through
deubiquitination
modification,
activation
signaling
pathway,
thereby
promoting
inflammation
contributing
injury.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(40), С. 14432 - 14457
Опубликована: Окт. 3, 2023
Neurological
disorders
are
diverse,
have
complex
causes,
and
often
result
in
disability;
yet,
effective
treatments
remain
scarce.
The
resveratrol
derivative
pterostilbene
possesses
numerous
physiological
activities
that
hold
promise
as
a
novel
therapy
for
the
central
nervous
system
(CNS)
disorders.
This
review
aimed
to
summarize
protective
mechanisms
of
vitro
vivo
models
CNS
pharmacokinetics
safety
assess
its
possible
effects
on
Available
evidence
supports
involving
such
antioxidant
anti-inflammatory
activity,
regulation
lipid
metabolism
vascular
smooth
muscle
cell
proliferation,
improvement
synaptic
function
neurogenesis,
induction
glioma
cycle
arrest,
inhibition
migration
invasion.
Studies
identified
molecular
targets
pathways
actions
including
AMPK/STAT3,
Akt,
NF-κB,
MAPK,
ERK
signaling
pathways.
pharmacological
critically
discussed
this
review.
Future
studies
should
aim
increase
our
understanding
animal
humans
further
evaluate
role
detailed
mechanisms.
Journal of Biomolecular Structure and Dynamics,
Год журнала:
2025,
Номер
unknown, С. 1 - 15
Опубликована: Апрель 24, 2025
Rheumatoid
arthritis
(RA)
is
a
chronic
inflammatory
disorder
characterized
by
joint
swelling,
cartilage
degradation,
and
deformity.
The
traditional
Chinese
herb
Cynanchum
paniculatum
(Bunge)
Kitag
has
been
utilized
in
the
management
of
RA,
but
underlying
mechanisms
are
unknown.
This
study
network
pharmacology
analysis
to
identify
26
active
compounds
associated
with
RA
treatment
elucidate
their
interactions
23
critical
targets
linked
RA.
Subsequently,
molecular
docking
studies
revealed
eight
capacity
bind
multiple
key
targets,
butyl
isobutyl
phthalate
geranyl
acetone
emerging
as
most
promising
candidates
based
on
drug-likeness
properties.
To
validate
these
findings,
rat
model
adjuvant-induced
was
employed.
Oral
administration
led
significant
reduction
paw
swelling
pro-inflammatory
markers,
including
TNF-α,
IL-6,
IL-1β,
MPO.
Furthermore,
it
resulted
histological
improvements
ankle
tissues,
all
without
adverse
effects
weight
or
immune
organs.
Mechanistically,
found
impede
progression
modulating
TLR4/MyD88/NF-κB
signaling
pathway.
In
conclusion,
C.
demonstrates
substantial
therapeutic
potential
for
due
its
multi-target
multi-pathway
activities.
Moreover,
acetone,
when
used
standalone
agent,
exhibits
promise
alleviating
symptoms,
offering
compelling
avenue
further
research
clinical
applications.
