The Role of AMPK Signaling in Ulcerative Colitis

Drug Design Development and Therapy, Год журнала: 2023, Номер Volume 17, С. 3855 - 3875

Опубликована: Дек. 1, 2023

Abstract: Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease characterized by inflammation and ulcer formation of the intestinal mucosa. Due to its high recurrence rate, prolonged course, limited curative options, significant impact on patients' quality life, along with notable potential for malignant transformation, UC designated as refractory global health challenge World Health Organization (WHO). The elucidation pathogenesis therapeutic strategies requires further in-depth investigation. AMP-activated protein kinase (AMPK) serves central regulator cellular energy metabolic homeostasis. Emerging evidence indicates that interventions involving traditional Chinese medicine (TCM) components, well other pharmacological measures, exert beneficial effects mucosal epithelial barrier dysfunction in modulating AMPK signaling, thereby influencing biological processes such autophagy, apoptosis, responses, macrophage polarization, NLRP3 inflammasome-mediated pyroptosis. role importance. This manuscript provides comprehensive overview mechanisms through which involved UC, compilation agents capable activating signaling pathway within context UC. primary objective facilitate deeper comprehension pivotal among researchers clinical practitioners, advancing identification novel targets Keywords: ulcerative colitis, AMPK, colitis-associated processes, monomers

Язык: Английский

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Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa

Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1941 - 1941

Опубликована: Июль 12, 2023

Cannabis sativa is a plant used for recreational and therapeutic purposes; however, many of the secondary metabolites in have not been thoroughly investigated. Stilbenes are class compounds with demonstrated anti-inflammatory antioxidant properties present cannabis. Many stilbenes cannabis investigated their effects. Fourteen identified to be cannabis, all which structurally dihydrostilbenoids, half possessing prenylated moiety. The summarized this analysis show varying degrees benefits ranging from anti-inflammatory, antiviral, anti-cancer researched limited extent potential health benefits. In addition, predictive silico modeling was performed on fourteen cannabis-derived stilbenes. This provides prospective activity, pharmacokinetic, metabolism, permeability data, setting groundwork further investigation into these poorly characterized compounds.

Язык: Английский

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Recent developments and new directions in the use of natural products for the treatment of inflammatory bowel disease

Phytomedicine, Год журнала: 2024, Номер 132, С. 155812 - 155812

Опубликована: Июнь 13, 2024

Язык: Английский

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Resveratrol for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июнь 14, 2024

Background: Inflammatory bowel disease (IBD) is a chronic condition that can be managed with treatment, but it challenging to get IBD cured. Resveratrol, non-flavonoid polyphenolic organic compound derived from various plants, has potential effect on IBD. The current research was set out investigate the therapeutic effects of resveratrol animal models Methods: A comprehensive search PubMed, Embase, Web Science, and Chinese databases performed. literature process completed independently by two people reviewed third person. risk bias in included assessed using Collaborative Approach Meta Analysis Review Animal Data Experimental Stroke (CAMARADES) 10-point quality checklist. meta-analysis utilized Manager 5.4 software evaluate efficacy resveratrol, histopathological index as primary outcome measure. Subgroup analysis conducted based this indicator. Additionally, meta-analyses were carried different outcomes reported literature, including final activity index, body weight change, colon length, splenic inflammatory factors. Results: After conducting thorough selection process, total 28 studies ultimately analysis. It found over half selected had more than five items low assessment. Relevant datas indicated group significantly lower control (WMD = −2.58 [-3.29, −1.87]). revealed higher doses (>80 mg/kg) better −3.47 [-4.97, −1.98]). Furthermore, data summary quantitative results SI length also showed effective alleviating intestinal mucosal pathological injury In terms biochemical indicators, affected interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), interferon-γ (IFN-γ), malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), prostaglandin E2 (PGE2) significantly. These may attributed mechanism regulating immune response inhibiting oxidative stress. Conclusion: This review suggests demonstrated notable impact preclinical IBD, particularly at exceeding 80 mg/kg. protective mechanisms targeting mucosa involved pathogenesis through pathways. As result, holds promising prospects for clinical use future.

Язык: Английский

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Salidroside Alleviates Furan-Induced Impaired Gut Barrier and Inflammation via Gut Microbiota–SCFA–TLR4 Signaling

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(29), С. 16484 - 16495

Опубликована: Июль 11, 2024

As a food contaminant that can be quickly absorbed through the gastrointestinal system, furan has been shown to disrupt intestinal flora and barrier. Investigation of toxicity mechanism is great significance health. We previously identified regulatory impact salidroside (SAL) against furan-provoked damage, present work further explored whether alleviating effect SAL furan-caused injury was based on flora; three models, normal, pseudo-germ-free, fecal microbiota transplantation (FMT), were established, changes in morphology, barrier, inflammation observed. Moreover, 16S rDNA sequencing observed variation associated with short-chain fatty acids (SCFAs). Results obtained from LC-MS/MS suggested increased furan-inhibited SCFA levels, activated mRNA expressions receptors (

Язык: Английский

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Punicalagin ameliorates DSS-induced colitis in mice through strengthening gut barrier, decreasing oxidative stress and downregulating inflammation via AMPK-NF-κB-STAT3 pathway

Food Bioscience, Год журнала: 2024, Номер 60, С. 104384 - 104384

Опубликована: Май 21, 2024

Язык: Английский

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Effects of Phenolic Acids Produced from Food-Derived Flavonoids and Amino Acids by the Gut Microbiota on Health and Disease

Molecules, Год журнала: 2024, Номер 29(21), С. 5102 - 5102

Опубликована: Окт. 29, 2024

The gut microbiota metabolizes flavonoids, amino acids, dietary fiber, and other components of foods to produce a variety microbiota-derived metabolites. Flavonoids are the largest group polyphenols, approximately 7000 flavonoids have been identified. A phenolic acids produced from through metabolic processes by microbiota. Furthermore, these easily absorbed. Phenolic generally represent compounds with one carboxylic acid group. Gut antiviral effects against several viruses, such as SARS-CoV-2 influenza. influence immune system inhibiting secretion proinflammatory cytokines, interleukin-1β tumor necrosis factor-α. In nervous systems, may protective neurodegenerative diseases, Alzheimer’s Parkinson’s diseases. Moreover, can improve levels blood glucose, cholesterols, triglycerides. also cardiovascular functions, pressure atherosclerotic lesions. This review focuses on current knowledge food-derived health disease.

Язык: Английский

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A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 7, 2025

Mitochondria are important organelles that regulate cellular energy and biosynthesis, as well maintain the body's response to environmental stress. Their dynamics autophagy influence occurrence of function, particularly under stressful conditions. They can generate reactive oxygen species (ROS) which is a major contributor inflammatory diseases such ulcerative colitis (UC). In this review, we discuss key effects mitochondrial mitophagy on pathogenesis UC, with particular focus metabolism, oxidative stress, apoptosis, immunoinflammatory activities. The therapeutic efficacy existing drugs phytochemicals targeting pathway discussed reveal insights for developing strategies treating UC. addition, new molecular checkpoints potential identified. We show integration biology clinical aspects UC may ideas enhancing management

Язык: Английский

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Kiwifruit Polyphenols Regulate Mitophagy to Promote Intestinal Barrier Function: Based on Proteomics, in vitro and in vivo study

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105847 - 105847

Опубликована: Янв. 1, 2025

Язык: Английский

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Resveratrol and Its Metabolites by Gut Microbiota Inhibit Human and Rat Gonadal 3β‐Hydroxysteroid Dehydrogenases: In Vitro Assay, Structure–Activity Relationship, and In Silico Docking Analysis

Journal of Food Biochemistry, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Introduction: Resveratrol and its analogs have potential therapeutic usage. is metabolized to various metabolites by gut microbiota, including dihydroresveratrol, lunularin, pinostilbene, oxyresveratrol. However, they might side effects inhibiting human gonadal 3β‐hydroxysteroid dehydrogenase 2 (h3β‐HSD2) rat homolog r3β‐HSD1, thereby interfering with steroid biosynthesis. Methods: Herein, we analyzed the inhibitory strength via in vitro assay, mode of action, structure–activity relationship, docking simulation resveratrol on 3β‐HSDs. Human KGN cell microsome was used as h3β‐HSD2 source, 90‐day‐old male Sprague–Dawley testicular r3β‐HSD1 source. The conversion pregnenolone progesterone 3β‐HSDs analyzed. Results: IC 50 values for were 4,4′‐dihydroxystilbene (8.87 μM) > pinostilbene (10.51 (50.04 lunularin (96.10 μM), while those (5.11 (15.16 (26.58 (34.32 μM). Most mixed/competitive inhibitors both Lipophilicity (LogP) lowest binding energy determined strength. Docking analysis showed that bind NAD + ‐/steroid‐binding sites Conclusion: can inhibit 3β‐HSDs, metabolism concentrations hormones such progesterone, testosterone, estradiol. Practical Application: Consequently, this interference could hold significance conditions related hormone imbalances, polycystic ovary syndrome certain cancers. Disorders marked elevated levels androgens, like hyperandrogenism, find benefit from interventions aimed at modulating 3β‐HSD activity. Hence, present themselves natural or supplementary treatment options managing conditions.

Язык: Английский

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