Role of mutation G255A in modulating pyrethroid sensitivity in insect sodium channels
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
295, С. 139455 - 139455
Опубликована: Янв. 7, 2025
Язык: Английский
A tiny sample rapid visual detection technology for imidacloprid resistance in Aphis gossypii by CRISPR/Cas12a
Rujing Kang,
Ren Li,
Juma Mjengi
и другие.
The Science of The Total Environment,
Год журнала:
2024,
Номер
951, С. 175712 - 175712
Опубликована: Авг. 23, 2024
Язык: Английский
The hygienic insecticide dimefluthrin induced neurodevelopmental deficits and behavioral disorders in zebrafish (Danio rerio) larvae
Environmental Research,
Год журнала:
2025,
Номер
268, С. 120777 - 120777
Опубликована: Янв. 6, 2025
Язык: Английский
Population genetics as a tool to understand invasion dynamics and insecticide resistance in indoor urban pest insects
Current Opinion in Insect Science,
Год журнала:
2024,
Номер
62, С. 101166 - 101166
Опубликована: Янв. 21, 2024
Язык: Английский
Cardiotoxicity risk induced by sanitary insecticide Dimefluthrin
Chemosphere,
Год журнала:
2024,
Номер
364, С. 142910 - 142910
Опубликована: Июль 26, 2024
Язык: Английский
Molecular Detection of kdr and superkdr Mutation Sites and Analysis of the Binding Modes of Pyrethroid Insecticides with Voltage-Gated Sodium Channels in the Plant Bug Lygus pratensis (Hemiptera: Miridae)
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 3, 2024
This
study
identified
genetic
mutations
linked
to
resistance
pyrethroid
insecticides
in
the
plant
pest
Lygus
pratensis.
The
voltage-gated
sodium
channel
(VGSC)
gene
was
cloned,
revealing
two
(Met918Thr
and
Leu1014Phe)
laboratory
strains
field
populations
from
Inner
Mongolia,
resulting
variable
resistance.
A
3D
model
of
LpVGSC
created
using
homology
modeling,
binding
patterns
were
analyzed
via
molecular
docking.
Molecular
dynamics
simulations
confirmed
structural
stability
changes
pyrethroids
VGSC
sites.
Mutation
frequencies
homozygous
heterozygous
genotypes
did
not
exceed
40
20%,
respectively.
Toxicity
tests
showed
high
λ-cyhalothrin
(LC50:401.31
ng/cm2).
kdr
(L1014F)
superkdr
(M918T)
weakened
interaction
forces,
reducing
binding.
M918T
L1014F
are
predicted
reduce
Type
I
affinity,
suggesting
II
may
be
more
effective
against
resistant
strains.
These
findings
aid
management
insecticide
design.
Язык: Английский
Functional Analysis of Two Carboxylesterase Genes Involved in Beta-Cypermethrin and Phoxim Resistance in Plutella xylostella (L.)
Agronomy,
Год журнала:
2024,
Номер
14(12), С. 2781 - 2781
Опубликована: Ноя. 23, 2024
Enhanced
expression
of
carboxylesterase
(CarE)
genes
is
an
important
mechanism
insecticide
resistance
in
pests.
However,
their
roles
multi-insecticide
have
rarely
been
reported.
Herein,
two
CarE
(PxαE6
and
PxαE9)
were
identified;
relative
levels
three
multi-insecticide-resistant
populations
P.
xylostella
(HN,
GD-2017
GD-2019)
2.69-
to
15.32-fold
higher
than
those
the
sensitive
population,
they
considerably
overexpressed
at
larval
stage
midgut
4th
instar.
PxαE6
PxαE9
knockdown
increased
susceptibility
GD-2019
larvae
phoxim
or/and
beta-cypermethrin.
The
recombinant
expressed
Escherichia
coli
exhibited
high
hydrolysis
activity
towards
α-NA.
GC–MS
LC–MS/MS
assays
revealed
that
could
metabolize
beta-cypermethrin
with
efficiency
determinations
51.6%
21.1%,
respectively,
while
12.0%.
Homology
modelling,
molecular
docking
molecular-dynamics
simulation
analyses
demonstrated
fit
well
into
active
pocket
stably
bind
or
PxαE9.
These
results
show
overexpression
involved
populations,
a
finding
which
sheds
light
on
mechanisms
insect
Язык: Английский
A Tiny Sample Rapid Visual Detection Technology for Imidacloprid Resistance in Aphis Gossypii by Crispr/Cas12a
Rujing Kang,
Ren Li,
Juma Mjengi
и другие.
Опубликована: Янв. 1, 2024
Язык: Английский
Alanine to glycine substitution in the PyR2 confers sodium channel resistance to Type I pyrethroids
Pest Management Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
Abstract
BACKGROUND
Aedes
aegypti
is
a
primary
urban
vector
of
dengue,
yellow
fever,
Zika
and
chikungunya
worldwide.
Pyrethroid
insecticides
are
the
most
effective
for
controlling
Ae.
.
However,
pyrethroid
resistance
has
developed
due
to
long‐term
overuse
insecticides,
many
knockdown
(kdr)
mutations
have
been
identified
in
resistant
populations.
A1007G,
an
alanine
glycine
substitution,
was
found
from
Vietnam
Malaysia,
which
always
co‐existed
with
F1534C
V1016G.
role
A1007G
linkage
or
V1016G
remain
unknown.
RESULTS
In
this
study,
we
examined
effects
on
sodium
channel
gating
properties
sensitivity
Xenopus
oocytes.
We
+
shifted
voltage
dependence
activation
depolarizing
direction.
Mutations
inactivation
Both
reduced
two
Type
I
pyrethroids,
permethrin
bifenthrin,
synergistic
were
observed
between
F1534C.
none
mutations,
affected
II
deltamethrin
cypermethrin.
Furthermore,
triple
significantly
both
pyrethroids.
CONCLUSION
had
distinct
effect
I,
but
not
also
exhibited
will
provide
fundamental
insight
into
molecular
interactions
insect
©
2024
Society
Chemical
Industry.
Язык: Английский