Dietary Polyphenols and Gut Microbiota Cross-Talk: Molecular and Therapeutic Perspectives for Cardiometabolic Disease: A Narrative Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 9118 - 9118

Опубликована: Авг. 22, 2024

The intricate interplay between the gut microbiota and polyphenols has emerged as a captivating frontier in understanding potentially harnessing therapeutic potential of these bioactive compounds. Phenolic compounds, renowned for their antioxidant, anti-inflammatory, antidiabetic, anticancer properties, are subject to transformations within milieu, where diverse microbial ecosystem exerts profound effects on metabolism bioavailability. Conversely, exhibit remarkable capacity modulate composition activity microbiota, fostering bidirectional relationship that extends beyond mere nutrient processing. This symbiotic interaction holds significant implications human health, particularly cardiometabolic diseases such diabetes mellitus, metabolic-dysfunction-associated steatotic liver disease, cardiovascular disease. Through comprehensive exploration molecular interactions, this narrative review elucidates reciprocal dynamics polyphenols, unveiling novel avenues intervention disorders. By unravelling cross-talk two entities, underscores multifaceted roles overall health pivotal role modulation promising strategy mitigating burden diseases.

Язык: Английский

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Naringenin cationic lipid-modified nanoparticles mitigate MASLD progression by modulating lipid homeostasis and gut microbiota

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 4, 2025

Naringenin (NAR) possesses various pharmacological activities including antioxidant, anti-inflammatory, and hepatoprotective effects. However, its therapeutic efficacy is limited by hydrophobic crystalline nature. This study aimed to investigate the potential molecular mechanisms of NAR efficiently loaded into cationic nanoparticles (NP-NAR) for treating metabolic dysfunction-associated steatotic liver disease (MASLD) in a mouse model. The results demonstrated that NP-NAR effectively ameliorated lipid metabolism dysbiosis, oxidative stress, insulin resistance, inflammation MASLD mice. Transcriptomic analysis data revealed promoted fatty acid oxidation via activation PPAR signaling pathway, reduced hepatic uptake lipogenesis inhibiting expressions key genes CD36, ACC, FASN. Moreover, modulated cholesterol classical bile synthesis pathway. 16 S rDNA gene sequencing disbalanced gut microbiota mice, whereas treatment statistically reversed abundance changes several intestinal bacteria at phylum genus levels, which partly contributed balance metabolite production, short-chain acids. In conclusion, these findings suggest may be promising candidate obesity-associated MASLD, offering new insight underlying NAR's against MASLD.

Язык: Английский

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Naringenin prevents non‐alcoholic steatohepatitis by modulating the host metabolome and intestinal microbiome in MCD diet‐fed mice

Food Science & Nutrition, Год журнала: 2023, Номер 11(12), С. 7826 - 7840

Опубликована: Сен. 27, 2023

Abstract Non‐alcoholic steatohepatitis (NASH) is a severe inflammatory phase of the non‐alcoholic fatty liver disease (NAFLD) spectrum and can progress to advanced stages NAFLD if left untreated. This study uses multi‐omics data elucidate underlying mechanism naringenin's reported benefit in alleviating (NASH). Male mice were fed NASH‐inducing (methionine‐choline‐deficient) MCD diet with or without naringenin supplementation for 6 weeks. Naringenin prevented NASH‐induced histopathological damage reversed abnormal levels hepatic triglyceride (TG)/total cholesterol (TC), serum TG/TC, alanine aminotransferase/aspartate transaminase, malondialdehyde glutathione. Importantly, intervention significantly modulated relative abundance gut microbiota host metabolomic profile. We detected more than 700 metabolites found that genus Anaeroplasma [Eubacterium] nodatum group closely associated xanthine, 2‐picoline, securinine, respectively. Tuzzerella alterations showed highest number associations endogenous such as FAHFA (8:0/10:0), FFA (20:2), carnitine C8:1, tridecanedioic acid, acetylvaline, DL‐O‐tyrosine, Phe‐Asn. indicates interplay between may contribute therapeutic effect against NASH.

Язык: Английский

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Quercetin: A Promising Candidate for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Molecules, Год журнала: 2024, Номер 29(22), С. 5245 - 5245

Опубликована: Ноя. 6, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a chronic disease. The development of MASLD is influenced by multitude diseases associated with modern lifestyles, including but not limited to diabetes mellitus, hypertension, hyperlipidaemia and obesity. These conditions are often consequences the adoption unhealthy habits, namely sedentary lifestyle, lack physical activity, poor dietary choices excessive alcohol consumption. treatment primarily based on modifying patient's lifestyle pharmacological intervention. Despite absence FDA-approved agents for MASLD, several potential therapeutic modalities have demonstrated efficacy in reversing histopathological features Among botanical ingredients belonging flavonoid group quercetin (QE). QE has been possess number beneficial physiological effects, anti-inflammatory, anticancer antifungal properties. Additionally, it functions as natural antioxidant. Preclinical evidence indicates that may play role reducing damage improving metabolic health. Early human studies also suggest be an effective due its antioxidant, lipid-regulating This review aims summarize available information effects MASLD.

Язык: Английский

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“Exploring the Efficacy and Mechanistic Action of Traditional Chinese Medicine-Derived Phytochemicals in Rheumatoid Arthritis”

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2025, Номер unknown, С. 100597 - 100597

Опубликована: Март 1, 2025

Язык: Английский

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Dietary Isoquercetin Reduces Hepatic Cholesterol and Triglyceride in NAFLD Mice by Modulating Bile Acid Metabolism via Intestinal FXR-FGF15 Signaling

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(20), С. 7723 - 7733

Опубликована: Май 11, 2023

Isoquercetin, a monosaccharide flavonoid, was recently reported to have significant amelioration effects on high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) of mice. However, the underlying mechanism hepatic cholesterol and triglyceride improvement in mice fed HFD by isoquercetin remains unclear. Here, combination 16S rRNA gene sequencing, targeted quantification bile acids (BAs), biological assays employed investigate beneficial NAFLD The results showed that dietary markedly modulated BAs profiling various samples such as liver, serum, intestine, feces. We found promoted BA biosynthesis via activation alternative pathways inhibition intestinal FXR-Fgf15 signaling, thus reducing 13.2% 16.05% Dietary also regulated series receptors mediating correspondent processes transportation, reabsorption, excretion. Of particular note, significantly cross-talk between specific gut bacteria These findings revealed long-term intake plays roles prevention or intervention disease.

Язык: Английский

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Polyphenols improve non‐alcoholic fatty liver disease via gut microbiota: A comprehensive review

Food Science & Nutrition, Год журнала: 2024, Номер 12(8), С. 5341 - 5356

Опубликована: Июнь 7, 2024

Abstract Polyphenols, natural micronutrients derived from plants, are valued for their anti‐inflammatory and antioxidant properties. The escalating global prevalence of non‐alcoholic fatty liver disease (NAFLD) underscores its status as a chronic progressive condition. Furthermore, the dysregulation gut microbiota (GM) is implicated in onset progression NAFLD through actions metabolites such bile acids (BAs), lipopolysaccharide (LPS), choline, short‐chain (SCFAs). Additionally, GM may influence integrity intestinal barrier. This review aims to evaluate potential effects polyphenols on barrier function, subsequent impact NAFLD. We searched wide range databases, Web Science, PubMed, EMBASE, Scopus gather information our non‐systematic English literature. functions composition can be regulated by chlorogenic acid, curcumin, green tea catechins, naringenin, quercetin, resveratrol, sulforaphane. Regulating improves alleviating inflammation, fat accumulation, enzymes. it serum lipid profile integrity. All these components affect GM, including SCFAs, LPS, BAs. Current evidence indicates that curcumin modulate improving positively impacting More studies necessary safety efficacy sulforaphane, catechin.

Язык: Английский

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Electrospray alginate microgels co-encapsulating degraded Konjac glucomannan and quercetin modulate human gut microbiota in vitro

Food Chemistry, Год журнала: 2023, Номер 434, С. 137508 - 137508

Опубликована: Сен. 16, 2023

Alginate microgels co-encapsulating degraded Konjac glucomannan (KGM60) underwent in vitro fecal fermentation and their effects on human microbiota metabolites were investigated. KGM60 delayed quercetin release enhanced phenolic production. Microgels increased linear short chain fatty acid but decreased branched encapsulated with or without Firmicutes while Bacteroidetes over 24 h of fermentation, at genus level promoted Bacteroides growth the abundance Negativibacillus, Ruminococcus_NK4A214, Christensenellaceae R_7. Faecalibacterium Collinsella levels exclusively by encapsulating quercetin, highlighting prebiotic effect KGM60. Only both Dialister inhibited Lachnoclostridium, indicating synergism between quercetin. Our study indicates that alginate microgel is effective modulating gut production potentially beneficial to health.

Язык: Английский

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Rutin, a natural flavonoid glycoside, ameliorates zearalenone induced liver inflammation via inhibiting lipopolysaccharide gut leakage and NF-κB signaling pathway in mice

Food and Chemical Toxicology, Год журнала: 2024, Номер 191, С. 114887 - 114887

Опубликована: Сен. 1, 2024

Язык: Английский

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Quercetin ameliorates celiac-related intestinal inflammation caused by wheat gluten through modulating oxidative stress, Th1/Th2/Treg balance, and intestinal microflora structure

Food & Function, Год журнала: 2024, Номер 15(18), С. 9343 - 9356

Опубликована: Янв. 1, 2024

Celiac disease is a chronic inflammatory autoimmune of the small bowel, and about 1% world's population afflicted with celiac disease. To date, most efficient treatment option that patient required to strictly follow gluten-free diet for their entire life, but it's difficult adhere can lead new nutritional imbalances, making it urgent find novel interventions. Our aim was explore effects intervention quercetin on toxic wheat gluten. This study systematically assessed regulatory roles intestinal oxidative damage, immune response, microflora dysbiosis in by utilizing established

Язык: Английский

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